Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘Animal Ethics Committee of China Pharmaceutical University.’ Author Contributions JA, GW, and YZ participated in research design. YZ, YH, JG, LJ, SL, and CY conducted the experiments. YZ, JG, RS, and YX performed the data analysis. YZ, JA, and GW wrote or contributed to the writing of the manuscript. All authors read and approved the final manuscript. Funding This study was financially supported by the National Natural Science Foundation of the People’s Republic of China (81573495, 81530098, and 81503342), the National Key Special Project of Science and Technology for Innovation Drugs of China (2015zx09501001 and 2017ZX09301013), the project of University Collaborative Innovation Center of Jiangsu Province (Modern Chinese Medicine Center and Biological Medicine Center), and National Natural Science Foundation of China Grant (No. 81503342). C...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research