Advancing mediation analysis in occupational health research

In recent years, mediation analysis has become a popular means to identify and quantify pathways linking an exposure to an outcome, thereby elucidating how a particular exposure contributes to the occurrence of a specific outcome. When a mediator is a modifiable risk factor, this opens up new opportunities for interventions to block (part) of the exposure`s effect on the outcome. Recent examples in Scandinavian Journal of Work Environment Health have addressed the mediating effect of wellbeing on the association between type of office and job satisfaction (1) and examined whether workplace social capital contributes to the association between organizational changes and employee exit from work (2). Mediation analysis requires a specific study design ensuring that the temporal sequence of exposure, mediator, and outcome supports the argument for causation. A good illustration presented by Halonen and colleagues (3) used the Swedish Longitudinal Occupational Survey of Health (SLOSH) with bian nual waves to investigate whether depressive symptoms mediated the association between effort–reward imbalance and subsequent neck-shoulder pain. The longitudinal design allowed for a mediation analysis whereby exposure was measured two years before the mediator, and the mediator was assessed two years before the outcome of interest. When exposure and mediator are self-reported, without assurance that the mediator occurred after the exposure (eg, years of education in school preced...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research

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Authors: Dietrich DE, Bode L, Spannhuth CW, Hecker H, Ludwig H, Emrich HM Abstract BACKGROUND: Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. This called to mind previous evidence for an infectious contribution of BDV-1 to mental disorders. Pilot open trials suggested that BDV-1 infected depressed patients benefitted from antiviral therapy with a licensed drug (amantadine) which also tested sensitive in vitro. Here, we designed a double-blind placebo-controlled randomized clinical trial (RCT) which cross-lin...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
In this study, we collected raw water from different elements of a local full-scale plant to investigate the fouling characteristics along a two-stage-module NF process. The fouled membranes at different flux decline ratios were autopsied according to scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometer (XPS), adenosine triphosphate (ATP), contact angle and zeta potential measurements to track the dynamic evolution of organic, inorganic and biological fouling. Statistical approaches, including principal component analysis (PCA), ...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
This correction reports and rectifies errors in several articles published in JAACAP between 2009 and 2011. Incorrect coding of the Suicidal Ideation Questionnaire-Jr resulted in the wrong reporting of the means for this measure and of the rate of participants with clinically significant suicidal ideation. The authors would like to apologize to the editorial staff and the readers for these mistakes.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Tags: Correction Source Type: research
Publication date: Available online 19 February 2020Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
This study was aimed to estimate the prevalence of chronic pain in different regions of China. Data on pain and its treatment were collected from 9357 participants using questionnaires and telephone-based interviews, from 31 regions of China. Gathered data were then coded into electronic data acquisition system and descriptive and inferential statistical analysis was performed. Out of 9298 participants, the ratio of chronic pain was 31.54% with the proportion of male having chronic pain (33.86%) was higher than that of female (29.53%). The average age of participants with pain (45.02 ± 15.07 years) was higher than f...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
Mol. Nutr. Food Res. 2020,64,https://doi.org/10.1002/mnfr.2019005501900550DOI:10.1002/mnfr.201900550Assembly of the NLRP3 inflammasome, consisting of ASC, NLRP3, and pro ‐caspase‐1, promotes neuroinflammation in neurological disorders. In articlehttps://doi.org/10.1002/mnfr.2019005501900550, Wei ‐Lun Hung, Chi‐Tang Ho, and Min‐Hsiung Pan summarize the pathogenic role of the NLRP3 inflammasome in neuroinflammation and highlight the current knowledge on the neuroprotective effects of phytochemicals for the treatment and prevention of neurological disorders through modulation of the NLRP 3 inflammasome.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Front Cover Source Type: research
ConclusionsInsects display a diversity of TM ‐associated IgE reactivity. It is likely that minor sequence features and/or structural effects are primarily responsible. Additionally, we demonstrate that some insect species may present significantly less IgE cross‐reactivity to shrimp than do others.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Conclusion: This study supports the psychometric properties of the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire in assessing self-efficacy in therapeutic encounters. Further research is needed to address the misfit items and the rating scale issue.Significance: Rasch analysis showed that the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire is promising to be used as a reliable and valid tool. PMID: 32065554 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Conclusion: People who are overweight or obese are motivated to lose weight because of health issues and feeling more comfortable with their body. The opportunities for weight loss lie in creating habits, routines and structuring everyday life activities to facilitate a healthier lifestyle.Significance: The findings indicate that an occupational therapist should be part of weight-loss interventions. PMID: 32065553 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Publication date: Available online 19 February 2020Source: Small Ruminant ResearchAuthor(s): Ratan K. Choudhary, Jaspal S. Hundal, Manju Wadhwa, Shanti Choudhary, NeetikaAbstractPlant oil supplementation in animal diet is a reliable feeding strategy to enhance omega-3 fatty acids content in milk and meat. To investigate oil induced differential gene expressions of milk protein genes (LALBA, CSN2) and fat synthesis genes (CD36, XDH, ACACA, SCD, FABP3) in mammary epithelial cells, twelve Beetal goats were fed with control diet (CON) and linseed oil (LSO) or chia oil (CO) supplemented diets (1%) for sixty days. Total RNA was ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
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