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Condition: Hypertension
Management: National Institutes of Health (NIH)

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Total 119 results found since Jan 2013.

Blood test identifies risk of disease linked to stroke and dementia
A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person ’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S. CSVD can lead to dementia and stroke, but currently it can only be diagnosed with an MRI scan of the brain.“The hope is that this will spawn a novel diagnostic test that clinicians can start to use as a quantitative measure of brain health in people who are at risk of developing cerebral small vessel disease,” said Dr. Jason Hinman, a UCLA assistant professor of neurology and lead author of t...
Source: UCLA Newsroom: Health Sciences - February 1, 2020 Category: Universities & Medical Training Source Type: news

Neuroimaging risk factors for participation restriction after acute ischemic stroke: 1-year follow-up study
The aim of the present study was to determine the neuroimaging predictors of poor participation after acute ischemic stroke. A total of 443 patients who had acute ischemic stroke were assessed. At 1-year recovery, the Reintegration to Normal Living Index was used to assess participation restriction. We also assessed the Activities of Daily Living Scale and modified Rankin Scale (mRS) score. Brain MRI measurement included acute infarcts and pre-existing abnormalities such as enlarged perivascular spaces, white matter lesions, ventricular-brain ratio, and medial temporal lobe atrophy (MTLA). The study included 324 men (73.1%...
Source: Journal of Investigative Medicine - January 25, 2022 Category: Research Authors: Qu, J.-F., Zhong, H.-H., Liang, W.-C., Chen, Y.-K., Liu, Y.-L., Li, W. Tags: Open access Original research Source Type: research

Infarction in the Anterior Choroidal Artery Territory: Clinical Progression and Prognosis Factors
This study was undertaken to describe the still poorly known evolving profile of anterior choroidal artery (AChA) infarctions, identify their prognosis factors, and evaluate responses to intravenous (IV) thrombolysis. During 42 months, we prospectively enrolled patients with an isolated AChA stroke. Clinical and radiologic parameters were compared between patients with or without progression, defined as any clinical worsening. Factors associated with poor outcome (dependence or death) were tested, and IV thrombolysis responses were assessed. For the 100 of 1234 (8.1%) analyzed patients with AChA stroke (predominantly lacu...
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Nicolas Chausson, Julien Joux, Martine Saint-Vil, Mireille Edimonana, Séverine Jeannin, Mathieu Aveillan, Philippe Cabre, Stéphane Olindo, Didier Smadja Tags: Original Articles Source Type: research

Admission clinical characteristics and early clinical outcomes among acute ischemic stroke patients
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Xin Gao , Jintao Zhang , Ying Peng , Huanqing Fan , Mei Chen , Tan Xu , Yonghong Zhang The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673 patients with acute ischemic stroke were included in the present study. The clinical characteristics at admission and other study variables were collected for all patients. The study outcome was defined as neurological deficien...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research

Left ventricular geometry and white matter lesions in ischemic stroke patients.
Authors: Butenaerts D, Chrzanowska-Wasko J, Slowik A, Dziedzic T Abstract Abnormal left ventricular (LV) geometry is associated with extracardiac organ damage in patients with hypertension. The aim of this study was to determine the relationship between LV geometry and white matter lesions (WMLs) in ischemic stroke patients. We retrospectively analyzed data from 155 patients (median age 62; 49.8% male) with mild ischemic stroke (median National Institutes of Health Stroke Scale score 4) who underwent brain magnetic resonance imaging and echocardiography. Patients were categorized into four groups: normal LV geometr...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Thrombolysis with alteplase 3 –4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances
In patients presenting to the emergency department with acute stroke, previous evidence from the Third European Cooperative Acute Stroke Study (ECASS III) recommended alteplase treatment within 3 to 4.5 hours of symptoms onset. Factors taken into consideration in the original report include time to treatment, history of smoking or hypertension, and an adjusted National Institute of Health Stroke Scale (NIHSS) score. However, it is unclear if accounting for history of stroke and baseline differences in NIHSS score on arrival may alter outcomes in patients given alteplase.
Source: The Journal of Emergency Medicine - October 1, 2020 Category: Emergency Medicine Authors: Anne Kathryn Watson, Amanda Young Tags: Abstract Source Type: research

Update on the SPRINT trial: Preliminary results pan out
In a previous blog, I reported on the preliminary results from SPRINT, a clinical trial that examined whether a systolic blood pressure target of 120 mm Hg or less would be better than a target of 140 mm Hg in patients with hypertension (high blood pressure). The National Heart, Lung, and Blood Institute of the National Institutes of Health issued a press release with the exciting results. Now, the full paper has been published in The New England Journal of Medicine, and the results appear to be as practice-changing at it initially seemed, demonstrating a stricter blood pressure goal can reduce the likelihood of dying. In ...
Source: New Harvard Health Information - November 9, 2015 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Health Heart Health Hypertension and Stroke Source Type: news

Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study
by Wei Yue, Anxin Wang, Runxiu Zhu, Zhongrui Yan, Shouhuan Zheng, Jingwei Wang, Jia Huo, Yunlin Liu, Xin Li, Yong Ji To investigate potential associations between carotid artery stenosis and cognitive impairment among patients with acute ischemic stroke and to provide important clinical implications. We measured the degree of carotid artery stenosis and recorded the Mini-Mental State Examination score (MMSE) at admission in 3116 acute ischemic stroke patients. The association between carotid stenosis and cognitive impairment assessed by MMSE was tested using multivariate regression analysis. Other clinical variables of in...
Source: PLoS One - January 11, 2016 Category: Biomedical Science Authors: Wei Yue et al. Source Type: research

Association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline in the acute phase of stroke with poor outcome after intravenous thrombolysis
In the acute phase of ischemic stroke, the trend of some physiological variables, such as blood glucose (BG), blood pressure, and body temperature (BT), might influence outcome. We aimed to assess the association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline BG, systolic blood pressure, diastolic blood pressure and BT, respectively, in the first 12 h with poor outcome after intravenous thrombolysis (IVT). We conducted a retrospective analysis of data prospectively collected from 200 consecutive anterior ischemic stroke patients treated with IVT. Outcome measures were no neur...
Source: Blood Coagulation and Fibrinolysis - February 9, 2018 Category: Hematology Tags: Original Articles Source Type: research

Serum 25-hydroxyvitamin D deficiency predicts poor outcome among acute ischemic stroke patients without hypertension
Publication date: Available online 3 May 2018 Source:Neurochemistry International Author(s): Bingjun Zhang, Yuge Wang, Yi Zhong, Siyuan Liao, Zhengqi Lu 25-Hydroxyvitamin D (25(OH)D) deficiency is a frequent condition in patients who suffer acute ischemic stroke (AIS), and several studies suggested that it may be associated with a poorer prognosis. Whether this association is affected by hypertension is unclear. Our aim was to investigate the association between 25(OH)D levels and both clinical severity and outcome after 3 months in AIS patients stratified by the history of hypertension. Consecutive first-ever AIS patient...
Source: Neurochemistry International - May 3, 2018 Category: Neuroscience Source Type: research

Estimation of stroke severity with National Institutes of Health Stroke Scale grading and retinal features: A cross-sectional study
To estimate National Institutes of Health Stroke Scale (NIHSS) grading of stroke patients with retinal characteristics. A cross-sectional study was conducted in Shenzhen Traditional Chinese Medicine Hospital. Baseline information and retinal photos were collected within 2 weeks of admission. An NIHSS score was measured for each patient by trained doctors. Patients were classified into 0 to 4 score group and 5 to 42 score group for analysis. Three multivariate logistic models, with traditional clinical characteristics alone, with retinal characteristics alone, and with both, were built. For clinical characteristics, h...
Source: Medicine - August 6, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Orolingual Angioedema with Alteplase Administration for Treatment of Acute Ischemic Stroke
A 68-year-old African-American male with a history of hypertension and gout (on lisinopril for approximately 1 year) presented to the Emergency Department with 2.5 h of left-arm weakness and numbness. Of note, the patient was in newly discovered rapid atrial fibrillation and, in light of persistent neurologic deficits (National Institutes of Health Stroke Scale 16→7) within 4.5 h, the decision was made to administer i.v. tissue plasminogen activator (tPA) for treatment of presumed embolic right middle cerebral artery stroke. Approximately 30 min post infusion, the patient developed severe diffuse orolingual angioedema of...
Source: The Journal of Emergency Medicine - May 13, 2013 Category: Emergency Medicine Authors: Elizabeth M. Gorski, Michael J. Schmidt Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Coronary Heart Disease Risk Factors and Outcomes in the Twenty-First Century: Findings from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Abstract REasons for Geographic and Racial Differences in Stroke (REGARDS) is a longitudinal study supported by the National Institutes of Health to determine the disparities in stroke-related mortality across USA. REGARDS has published a body of work designed to understand the disparities in prevalence, awareness, treatment, and control of coronary heart disease (CHD) and its risk factors in a biracial national cohort. REGARDS has focused on racial and geographical disparities in the quality and access to health care, the influence of lack of medical insurance, and has attempted to contrast current guidelines in...
Source: Current Hypertension Reports - March 21, 2015 Category: Primary Care Source Type: research