Association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline in the acute phase of stroke with poor outcome after intravenous thrombolysis

In the acute phase of ischemic stroke, the trend of some physiological variables, such as blood glucose (BG), blood pressure, and body temperature (BT), might influence outcome. We aimed to assess the association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline BG, systolic blood pressure, diastolic blood pressure and BT, respectively, in the first 12 h with poor outcome after intravenous thrombolysis (IVT). We conducted a retrospective analysis of data prospectively collected from 200 consecutive anterior ischemic stroke patients treated with IVT. Outcome measures were no neurological improvement at 24 h (National Institutes of Health Stroke Scale (NIHSS) score at 24 h ≥NIHSS score at baseline), and unfavorable functional outcome [modified Rankin Scale (mRS) score 3–6] at 3 months. No neurological improvement at 24 h was noted in 52 (26%) patients and mRS 3–6 at 3 months in 68 (34%) patients. The multivariate analyses showed that odds ratios (ORs) for no neurological improvement at 24 h were higher in patients with hyperglycemia relative to baseline [OR 3.50, 95% confidence interval (CI) 1.43–8.57, P = 0.006], and hyperthermia relative to baseline (OR 2.88, 95% CI 1.20–6.91, P = 0.018). OR for 3-month mRS score 3–6 was higher in patients with hyperthermia relative to baseline (OR 3.05, 95% CI 1.20–7.74, P = 0.019). Hyperglycemia and hyperthermia relative to baseline in th...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Original Articles Source Type: research

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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
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Source: Current Hypertension Reports - Category: Primary Care Source Type: research
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Source: Ophthalmic Research - Category: Opthalmology Source Type: research
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Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
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Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
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Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research
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Source: Journal of the Chinese Medical Association - Category: General Medicine Source Type: research
This study retrospectively analyzed 166 patients with ischemic stroke or transient ischemic attacks admitted in the Geriatric Neurology Department of Chinese PLA General Hospital between February 2010 and December 2012. We collected clinical characteristics and risk factors of CMBs. The location of CMBs on T2*-weighted angiography was assessed by the Microbleed Anatomical Rating Scale. The number of lacunar infarcts and the severity of white matter hyperintensities were also recorded. The association between the location of CMBs and lacunar infarcts parameters was examined. CMBs were present in 77 (46.4%) patients. The pr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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Source: Journal of Hypertension - Category: Cardiology Tags: Consensus Documents Source Type: research
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