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Specialty: Internal Medicine
Condition: Diabetes

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Total 443 results found since Jan 2013.

Aspirin plus clopidogrel in acute minor ischaemic stroke or transient ischaemic attack is superior to aspirin alone for stroke risk reduction: CHANCE trial
Commentary on: Wang Y, Wang Y, Zhao X, et al.. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11–19. Context Combination therapy with aspirin added to clopidogrel has had a disappointing record in the prevention of recurrent stroke. The management of atherothrombosis with clopidogrel in high-risk patients (MATCH)1 and the secondary prevention of small subcortical strokes (SPS3)2 randomised controlled trials (RCTs) showed that combination therapy was not more effective than clopidogrel or aspirin alone, but was associated with two to three times the risk of major or ...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Gorelick, P. B., Farooq, M. U. Tags: Smoking and tobacco, Clinical trials (epidemiology), Genetics, Stroke, Hypertension, Diabetes, Health education, Smoking Therapeutics Source Type: research

Non-vitamin-K oral anticoagulants reduce mortality, stroke and intracranial haemorrhage when compared with warfarin in randomised trials of patients with non-valvular atrial fibrillation
Commentary on: Ruff CT, Giugliano RP, Braunwald E, et al.. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014;383:955–62. Context Historically, the standard medication for stroke prevention in atrial fibrillation (AF) has been a vitamin-K antagonist (warfarin). However, several non-vitamin-K oral anticoagulants (NOACs) have been developed and shown to be at least as effective as dose-adjusted warfarin in their respective phase-3 clinical trials.1–4 These include the direct thrombin inhibitor dabig...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Steinberg, B. A. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Connective tissue disease, Musculoskeletal syndromes, Diabetes, Arrhythmias Therapeutics Source Type: research

Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study
ConclusionsNight-onset strokes, compared with day-onset strokes, are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome. These findings suggest that circadian time of onset is an important additional variable for inclusion in epidemiologic natural history studies and in treatment trials of neuroprotective and reperfusion agents for acute ischemic stroke.
Source: PLoS Medicine - February 4, 2022 Category: Internal Medicine Authors: Wi-Sun Ryu Source Type: research

Undetermined stroke with an embolic pattern--a common phenotype with high early recurrence risk.
CONCLUSIONS: Despite their younger age and more favorable risk factor profile compared with other phenotypes, USEP exhibited a high risk of stroke recurrence. PMID: 26224200 [PubMed - indexed for MEDLINE]
Source: Annals of Medicine - February 18, 2016 Category: Internal Medicine Tags: Ann Med Source Type: research

Association between heat stroke and ischemic heart disease: A national longitudinal cohort study in Taiwan.
In conclusion, clinicians should be aware about evaluating the IHD risk following a heat stroke episode in a patient. PMID: 30297250 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - October 5, 2018 Category: Internal Medicine Authors: Tseng MF, Chou CL, Chung CH, Chien WC, Chen YK, Yang HC, Chu P Tags: Eur J Intern Med Source Type: research

Urban-rural differences in risk factors for ischemic stroke in northern China
This study aims to investigate urban-rural differences in characteristics and risk factors of ischemic stroke in northern China. The present cross-sectional study was based on the High-risk Population Screening and Intervention Project for Stroke. The cluster sampling method was used to select urban and rural screening sites in northern China. By collecting information and screening the data, patients with ischemic stroke were obtained and a control group with similar gender, age, and regional distribution was selected among the nonischemic stroke patients. Then, the demographic and risk factors of patients with ischemic ...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Usefulness of cardiometabolic index for the estimation of ischemic stroke risk among general population in rural China.
CONCLUSION: The strong and independent association of CMI with ischemic stroke in females, in comparison with the much lesser degree in males, provides further insight to better stratify by sex in investigations of ischemic stroke and solidly corroborates the potential role of ischemic stroke prevention targeted at CMI. PMID: 28870109 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - September 7, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

A nonlinear association between resting heart rate and ischemic stroke among community elderly hypertensive patients.
Conclusions: In Chinese elderly hypertensive patients, elevated resting heart rate was an independent predictor of ischemic stroke, and the optimal resting heart rate was around 70bpm. PMID: 31829063 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - December 13, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Exaggerated exercise blood pressure response and risk of stroke in patients referred for stress testing.
CONCLUSION: We did not observe any significant association between exercise SBP and the future occurrence of stroke in patients with known or suspected CAD referred for exercise echocardiography. PMID: 24930070 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 11, 2014 Category: Internal Medicine Authors: Bouzas-Mosquera MD, Bouzas-Mosquera A, Peteiro J, Broullón FJ, Alvarez-García N, Castro-Beiras A Tags: Eur J Intern Med Source Type: research

Pregnancy increases stroke risk up to 1 year postpartum and reduces long-term risk
Conclusion: The risk of stroke was elevated during the first year postpartum, but lower in subsequent years. Stroke risk increased in multiparous ( ≥3) women. Physicians should be on alert for pregnancy complications and ensure appropriate management to prevent postpartum stroke.
Source: QJM - January 9, 2017 Category: Internal Medicine Source Type: research

Validation of the R2CHADS2 and CHADS2 Scores for Predicting Post-stroke Cognitive Impairment.
Conclusion These results suggest that the R2CHADS2 and CHADS2 scores are useful for predicting post-stroke cognitive impairment. PMID: 28924104 [PubMed - as supplied by publisher]
Source: Internal Medicine - September 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Antidiabetic drugs and stroke risk. Current evidence.
Abstract Cardiovascular disease (CVD) is the major cause of morbidity and mortality for individuals with type 2 diabetes (T2D). In particular, the risk for stroke is twice that of patients without diabetes, and diabetes may be responsible for >8% of first ischemic strokes. Therefore, the way to prevent stroke in these patients has become an important issue. Traditionally, glucose-lowering drugs had not been shown to protect against stroke. Moreover, several antidiabetic drugs (i.e., sulfonylureas, rosiglitazone) have been reported to be associated with increased risks of CVD and stroke. On the contrary, data on...
Source: European Journal of Internal Medicine - September 20, 2017 Category: Internal Medicine Authors: Castilla-Guerra L, Fernandez-Moreno MDC, Leon-Jimenez D, Carmona-Nimo E Tags: Eur J Intern Med Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - April 30, 2016 Category: Internal Medicine Authors: M. Würtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short ‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - May 2, 2016 Category: Internal Medicine Authors: M. W ürtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies
by Germ án D. Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K. Magnusson, Peter M. Nilsson, Nancy L. Pedersen, Alicja Wolk, Karin Leander BackgroundRecent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT i...
Source: PLoS Medicine - November 17, 2017 Category: Internal Medicine Authors: Germ án D. Carrasquilla Source Type: research