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Associations between nonalcoholic fatty liver disease and ischemic stroke.
Authors: Alkagiet S, Papagiannis A, Tziomalos K Abstract Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease and affects a considerable proportion of the general population. NAFLD is independently associated with increased risk for cardiovascular events, particularly coronary heart disease. Importantly, even though NAFLD is more prevalent in patients with major cardiovascular risk factors (e.g., type 2 diabetes mellitus, obesity and hypertension), the association between NAFLD and cardiovascular disease appears to be independent of these risk factors. However, NAFLD also appears to incre...
Source: World Journal of Hepatology - August 12, 2018 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Association Between Proton Pump Inhibitor Use and Risk of  Stroke
We read with interest the article by Nguyen et  al1 evaluating the association between proton pump inhibitor (PPI) use and ischemic stroke. The authors found that PPI use was associated with a significant increase in the risk of ischemic stroke after adjustment for established risk factors for stroke including smoking status, body mass index, p hysical activity, dietary quality, alcohol use, menopausal hormone use in women, multivitamin use, regular aspirin use, regular nonaspirin nonsteroidal anti-inflammatory drug, use and personal history of hypertension, hyperlipidemia, coronary artery disease, or diabetes.
Source: Gastroenterology - August 6, 2018 Category: Gastroenterology Authors: Cong Dai, Min Jiang, Ming-Jun Sun Tags: Correspondence Source Type: research

Predictors of inadequate bowel preparation for colonoscopy: a systematic review and meta-analysis
The aim of this study was to investigate factors contributing to poor bowel preparation in patients undergoing colonoscopy procedures. We used a reproducible search strategy to identify studies, searching 10 medical databases, including PubMed, Ovid, Medline, and Cochrane Library Database for reports published between 2000 and 2016. Fully published studies, evaluating risk factors for inadequate bowel preparation, were included. Two reviewers independently scored the identified studies for methodology and abstracted pertinent data. Pooling was conducted with both fixed-effects and random-effects models; results were presen...
Source: European Journal of Gastroenterology and Hepatology - July 6, 2018 Category: Gastroenterology Tags: Review Articles: Gastroenterology Source Type: research

Impact of NAFLD on the Incidence of Cardiovascular Diseases in a Primary Care Population in Germany
ConclusionsNAFLD constitutes an independent risk factor for CHD, MI, and AF in primary care in Germany. Identification of patients with NAFLD in primary care will allow specifically managing and modifying underlying risk factors to improve the overall prognosis.
Source: Digestive Diseases and Sciences - December 2, 2019 Category: Gastroenterology Source Type: research

Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms.
Abstract Hepatitis C virus (HCV) infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases, which are associated with excess mortality. Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis, heart failure and stroke. In contrast, findings from studies addressing coronary artery disease and HCV have yielded conflicting results. Therefore, meta-analytic reviews and prospective studies are warranted. The pathogenic mechani...
Source: World Journal of Gastroenterology : WJG - April 7, 2014 Category: Gastroenterology Authors: Adinolfi LE, Zampino R, Restivo L, Lonardo A, Guerrera B, Marrone A, Nascimbeni F, Florio A, Loria P Tags: World J Gastroenterol Source Type: research

Adiponectin: a relevant player in obesity-related colorectal cancer?
Obesity is a condition characterised by an abnormally elevated mass of body fat. The past decades have seen a dramatic rise in the worldwide incidence of obesity due to lifestyle changes that have led to an overall reduced physical activity and an increase in the intake of excessive and/or highly caloric or processed foods. As a consequence, obesity represents nowadays a major global health concern. In particular, several epidemiological studies have linked obesity to a shortened lifespan due primarily to a higher risk for the development of chronic pathologies that include cardiovascular complications such as high blood p...
Source: Gut - February 28, 2013 Category: Gastroenterology Authors: Cava, A. L. Tags: Commentary Source Type: research

Can Daily Coffee Consumption Reduce Liver Disease–Related Mortality?
Because of widespread skepticism regarding the safety of Western medication, there is great interest in studying alternative treatments that are considered natural and safe from toxicities. Many foods and diets are believed to promote health and longevity. Coffee is a beverage with a distinct taste and aroma that commonly is consumed throughout the world and is being assessed for its potential health benefits. For instance, a decreased risk of type 2 diabetes, heart disease, and stroke has been described in regular coffee drinkers. In a recent analysis of the National Institutes of Health–AARP Diet and Health Study data ...
Source: Clinical Gastroenterology and Hepatology - July 1, 2013 Category: Gastroenterology Authors: Vivian Ng, Sammy Saab Tags: Editorial Source Type: research

Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment
have been produced by the Japan Gastroenterological Endoscopy Society in collaboration with the Japan Circulation Society, the Japanese Society of Neurology, the Japan Stroke Society, the Japanese Society on Thrombosis and Hemostasis and the Japan Diabetes Society. Previous guidelines from the Japan Gastroenterological Endoscopy Society have focused primarily on prevention of hemorrhage after gastroenterological endoscopy as a result of continuation ofantithrombotic therapy, without considering the associated risk of thrombosis. The new edition of the guidelines includes discussions of gastroenterological hemorrhage assoc...
Source: Digestive Endoscopy - November 12, 2013 Category: Gastroenterology Authors: Kazuma Fujimoto, Mitsuhiro Fujishiro, Mototsugu Kato, Kazuhide Higuchi, Ryuichi Iwakiri, Choitsu Sakamoto, Shinichiro Uchiyama, Atsunori Kashiwagi, Hisao Ogawa, Kazunari Murakami, Tetsuya Mine, Junji Yoshino, Yoshikazu Kinoshita, Masao Ichinose, Toshiyuki Tags: Guideline Source Type: research

Metabolic consequences of Helicobacter pylori infection and eradication.
Abstract Helicobacter pylori (H. pylori) is still the most prevalent infection of the world. Colonization of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications (peptic ulcer, gastric cancer, lymphoma) and remote manifestations. While H. pylori does not enter circulation, these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed mucosa. The epidemiologic link between the H. pylori infection and metabolic changes is inconstant and controversial. Growth delay was des...
Source: World Journal of Gastroenterology : WJG - May 14, 2014 Category: Gastroenterology Authors: Buzás GM Tags: World J Gastroenterol Source Type: research

Coffee: A Panacea or Snake Oil for the Liver?
The United States is the world's biggest consumer of coffee. Approximately 83% of adults drink coffee in the United States according to the National Coffee Association's 2013 survey. There has been much interest in the potential health benefits both in scientific journals and lay media. One such example is a study by Freedman et al,1 which showed a significant, dose-dependent, inverse relationship between coffee and mortality. The benefits spanned a broad range of health conditions: consumption of coffee was associated with reduced mortality not only from heart disease, stroke, and diabetes, but also infections, respirato...
Source: Clinical Gastroenterology and Hepatology - April 24, 2014 Category: Gastroenterology Authors: Radhika Kumari, W. Ray Kim Tags: Original article Source Type: research

Factors Associated with Conversion from Laparoscopic to Open Colectomy using the National Surgical Quality Improvement Program (NSQIP) Database
ConclusionsMultiple significant factors for conversion from laparoscopic to open colectomy were identified. A novel finding was the increased risk of conversion for underweight patients. As laparoscopic colectomy is become increasingly utilized, factors predictive of conversion to open procedures should be sought via large, national cohorts.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - October 14, 2014 Category: Gastroenterology Authors: Anuradha R. Bhama, Mary E. Charlton, Mary B. Schmitt, John W. Cromwell, John C. Byrn Tags: Original Article Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

Balancing risk and reward: a critical review of the intragastric balloon for weight loss
Worldwide, more than 1.4 billion adults are overweight or obese and either have or are at increased risk of numerous, potentially disabling conditions. In the United States, 68% of adults are overweight or obese, and the epidemic is spreading to children.1,2 Obesity is associated with a number of comorbidities including type 2 diabetes mellitus, coronary heart disease, sleep apnea, stroke, gallbladder and liver disease, musculoskeletal disease, and an increase in the prevalence of certain cancers.
Source: Gastrointestinal Endoscopy - April 14, 2015 Category: Gastroenterology Authors: Shantanu Gaur, Samuel Levy, Lisbeth Mathus-Vliegen, Ram Chuttani Tags: Review article Source Type: research

Impact of Renal Impairment on Cardiovascular Disease Mortality After Liver Transplantation for Nonalcoholic Steatohepatitis Cirrhosis
ConclusionNASH recipients have an increased risk of CVD mortality after liver transplantation explained by a high prevalence of co‐morbid cardiometabolic risk factors that in aggregate identify those at highest risk of post‐transplant CVD mortality.This article is protected by copyright. All rights reserved.
Source: Liver International - May 15, 2015 Category: Gastroenterology Authors: Lisa B. VanWagner, Brittany Lapin, Anton I. Skaro, Donald M. Lloyd‐Jones, Mary E. Rinella Tags: Original Article Source Type: research

Relationship of sitting time and physical activity with non-alcoholic fatty liver disease
Physical activity is well-recognized to reduce the incidence and mortality of various chronic diseases, including cardiovascular disease, diabetes, stroke and several types of cancer [1–3]. More than one half of the average person’s waking day involves sedentary activities associated with prolonged sitting such as watching TV and using the computer [4]. Recently, the deleterious effects of sedentary behavior regardless of additional physical activity have received a great deal of attention [5–8].
Source: Journal of Hepatology - September 14, 2015 Category: Gastroenterology Authors: Seungho Ryu, Yoosoo Chang, Hyun-Suk Jung, Kyung Eun Yun, Min-Jung Kwon, Yuni Choi, Chan-Won Kim, Juhee Cho, Byung-Seong Suh, Yong Kyun Cho, Eun Chul Chung, Hocheol Shin, Yeon Soo Kim Tags: Research Article Source Type: research

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