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Specialty: Cardiology
Condition: Metabolic Syndrome

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Total 151 results found since Jan 2013.

Abstract P636: Sex Differences in Cardioprotective AT2R Expression in Diabetic Rats and Its Correlation with Myocardial Damage Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease (CVD). Healthy, young women are protected from CVD, while diabetic women are more susceptible to CVD compared to age-matched diabetic men and non-diabetic women. Underlying mechanisms for this sex difference in CVD are not fully elucidated. The angiotensin II type 2 receptor (AT2R) is a member of the protective, vasodilative arm of the renin angiotensin system. The Agtr2 gene that codes for AT2R is X-linked, and increased Agtr2 expression is reported in female vasculature of rodent models. We hypothesized that a sex difference might exist in DM...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Lum-Naihe, K., Mahmood, A., Bajwa, J., Emter, C. A., Pulakat, L. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research

Abstract P638: Investigating Gene Pleiotropy in the Metabolic Syndrome in Lyon Hypertensive Rats Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
The metabolic syndrome (MetS) - hypertension, obesity, dyslipidemia, and insulin resistance - is a major risk factor for cardiovascular disease and stroke. Our overall goal is to identify novel genes and pathways causing MetS. Our previous work determined that rat chromosome 17 (RNO17) contributes to several MetS-defining traits (including high blood pressure, obesity, and dyslipidemia) in the Lyon Hypertensive (LH) rat, a genetically determined MetS rat model. We hypothesized that at least some of the traits on RNO17 are controlled by a single gene with pleiotropic effects. To address this hypothesis, we generated congeni...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Kwitek, A. E., Pettus, J., Jakoubek, J., Ma, J. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research

Development of new atherosclerotic plaque in hypertensive patients: an observational registry study from the Campania-Salute network
Background and purpose: Carotid atherosclerotic plaques (CAPs) can develop despite appropriate antihypertensive therapy. In this observational study, we assessed characteristics associated with risk of incident CAP in a large hypertensive registry. Methods: We evaluated 2143 hypertensive patients without evidence of CAP. Incident CAP was censored at the time of the first ultrasound control in which CAP was detected. CAP was defined according to European Society of Hypertension/European Society of Cardiology guidelines. Results: At a median follow-up period of 56.6 months, about one-third of patients (32%; N = 688) exhi...
Source: Journal of Hypertension - November 12, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Blood vessels Source Type: research

Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese Zucker rats
This study determined the structural and functional changes in the middle cerebral arteries (MCA) during the progression of MetS and the effects of chronic pharmacological interventions on mitigating vascular alterations in obese Zucker rats (OZR), a translationally relevant model of MetS. The reactivity and wall mechanics of ex vivo pressurized MCA from lean Zucker rats (LZR) and OZR were determined at 7–8, 12–13, and 16–17 wk of age under control conditions and following chronic treatment with pharmacological agents targeting specific systemic pathologies. With increasing age, control OZR demonstrated r...
Source: AJP: Heart and Circulatory Physiology - December 1, 2015 Category: Cardiology Authors: Brooks, S. D., DeVallance, E., d'Audiffret, A. C., Frisbee, S. J., Tabone, L. E., Shrader, C. D., Frisbee, J. C., Chantler, P. D. Tags: CALL FOR PAPERS Source Type: research

Efficacy and safety of combined antihypertensive therapy with ramipril and moxonidine in patients with metabolic syndrome
Hypertension is a strong contributor to cardiovascular disease in patients with the metabolic syndrome. It has been shown to not only be an independent risk factor, but it also contributes to the development of other risk factors for cardiovascular disease. Over the last few decades, a number of classes of anti-hypertensive drugs have been used to treat hypertension, with the ultimate goal of reducing the incidence of endpoints such as heart attacks and stroke.
Source: Journal of the American Society of Hypertension - March 31, 2016 Category: Cardiology Authors: Jamol Kamilovich Uzokov, Aniskhon Lutfullayevich Alyavi, Ilhom Yunuskhonovich Akhmedov, Bekzod Bakhodirovich Karimov, Eldor Jurakulovich Rakhmonkulov Tags: Clinical Trials in Hypertension and Related Morbidities Source Type: research

Prevalence of atherosclerotic carotid plaques in semi-rural Gueoul, Senegal: Survey of 1411 subjects.
CONCLUSION: Prevalence of atherosclerotic carotid plaques seems weak but it is associated with many cardiovascular risk factors. It requires measures for early diagnosis and prevention of cardiovascular diseases in Senegal. PMID: 27090099 [PubMed - as supplied by publisher]
Source: Journal des Maladies Vasculaires - April 14, 2016 Category: Cardiology Authors: Babaka K, Sarr SA, Kane AD, Mbaye A, Ngaïde AA, Fobang Djiogap DH, Bodian M, Ndiaye MB, Ndour-Mbaye M, Diao M, Diack B, Kane M, Diagne-Sow D, Kane A Tags: J Mal Vasc Source Type: research

The characteristics of arterial hypertension in postmenopausal women in the area of Blida (Algeria).
CONCLUSIONS: The systolic blood pressure is more important than the diastolic blood pressure in postmenopausal women. The cerebral vascular accident remains the most feared complication. The control of hypertension remains not enough and the balance of arterial pressure figures is highly recommended to avoid morbidity and fatal complications. PMID: 27207267 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - May 16, 2016 Category: Cardiology Authors: Bachir Cherif A, Bouamra A, Taleb A, Bouraghda A, Rabia S, Imouloudene N, Temmar M, Bouafia MT Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Non-HDL-C vs. LDL-C in Predicting the Severity of Coronary Atherosclerosis
Atherosclerosis is a complex process involving multiple interfaces among inflammation, hypertension, age, ectopic obesity, diabetes, metabolic syndrome, dyslipidaemias, poor diet, smoking, sedentary lifestyle, impaired immune system, endothelial, vascular, hormonal and coagulation [1 –3]. Dyslipidaemia is a risk factor for coronary artery disease (CAD), stroke, metabolic syndrome (MetS) peripheral artery disease. Early diagnosis and management are key factors in the prevention of atherosclerotic disease and development of cardiovascular events [4,5].
Source: Heart, Lung and Circulation - July 5, 2016 Category: Cardiology Authors: Leonardo Roever, Giuseppe Biondi-Zoccai, Antonio Carlos Palandri Chagas Tags: Editorial Source Type: research

Gender Discrepancy in Diabetic Patients Hospitalized With Heart Failure: Does Age Matter?
Conclusions: In DHF, female gender is characterized by having a high prevalence of metabolic syndrome components. Also, females are more likely to have better Left ventricular ejection fraction but less likely to receive cardiovascular evidence based medications. There is no significant difference in the overall hospital mortality between both genders, however, in the younger age; males have a significantly higher mortality.
Source: Critical Pathways in Cardiology - August 2, 2016 Category: Cardiology Tags: Original Studies Source Type: research

Elevated estimated arterial age is associated with metabolic syndrome and low-grade inflammation
Background: Arterial age can be estimated from equations relating arterial stiffness to age and blood pressure in large cohorts. We investigated whether estimated arterial age (eAA) was elevated in patients with the metabolic syndrome and/or known cardiovascular disease (CVD), which factors were associated with eAA and whether eAA added prognostic information. Methods: In 1993, 2366 study participants, 41, 51, 61, and 71 years old, had traditional cardiovascular risk factors and carotid–femoral pulse wave velocity (cfPWV) measured. Risk groups were identified based on known CVD and components of metabolic syndrome, Syst...
Source: Journal of Hypertension - November 4, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Inflammation Source Type: research

Protocol for Evaluating the Cardio-Ankle Vascular Index to Predict Cardiovascular Events in Japan: A Prospective Multicenter Cohort Study
The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients.Methods and Design: This prospective multicenter study to evaluate the usefulness of the CAVI to predict cardiovascular events in Japan (CAVI-J) is a cohort study with central registration. Participants (n = 3,000) will be scheduled to enroll and data will be collected for up to 5 years from entry of participants into the study. To be eligible to participate in the CAVI-J study, individuals have to be aged between 40 and 74 years and have at least one of the following risk factors for arterios...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.
Abstract Diabetes mellitus increasingly afflicts our aging and dysmetabolic population. Type 2 diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the disease burden-increasingly prevalent in children and older adults. However, type 1 diabetes mellitus is also advancing in preadolescent children. As such, a crushing wave of cardiometabolic disease burden now faces our society. Arteriosclerotic calcification is increased in metabolic syndrome, type 2 diabetes mellitus, and type 1 diabetes mellitus-impairing conduit vessel compliance and function, thereby increasing the risk for de...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 21, 2016 Category: Cardiology Authors: Stabley JN, Towler DA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Influence of Inflammation and Atherosclerosis in Atrial Fibrillation
AbstractBackgroundInflammation markers have been associated with cardiovascular diseases including atrial fibrillation. This arrhythmia is the most frequent, with an incidence of 38/1000 person-years.Purpose of ReviewThe aims of this study are to discuss the association between inflammation, atherosclerosis and atrial fibrillation and its clinical implications.Recent Findings and SummaryAtherosclerosis is a chronic inflammatory disease and inflammation is a triggering factor of atherosclerotic plaque rupture. In addition to coronary artery disease, clinical conditions identified as risk factors for atrial fibrillation (AF)...
Source: Current Atherosclerosis Reports - January 18, 2017 Category: Cardiology Source Type: research

Hypertension and hyperglycemia and the combination thereof enhances the incidence of chronic kidney disease (CKD) in middle-aged and older males.
CONCLUSIONS: These results suggest that the hypertension and hyperglycemia and their combination may be associated with the incidence of CKD. PMID: 28590145 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - June 7, 2017 Category: Cardiology Authors: Michishita R, Matsuda T, Kawakami S, Tanaka S, Kiyonaga A, Tanaka H, Morito N, Higaki Y Tags: Clin Exp Hypertens Source Type: research

Abstract P201: Prevalence of Metabolic Syndrome in Hypertensive Patients Session Title: Onsite Poster Competition I With Reception
This study was done to find out the prevalence of metabolic syndrome among newly diagnosed hypertensive patients in a tertiary care hospital of northern India, Guru Nanak Dev hospital, attached to Government Medical College, Amritsar, India.Methods: It is a hospital based cross sectional study involving one hundred newly diagnosed subjects with hypertension above the age 20 years. High blood pressure was defined according to Joint National committe-7 (JNC-7) guidelines, taking systolic BP> 140 and diastolic BP>90 as hypertension. Exclusion criteria included secondary hypertension, secondary cause of obesity, pregnancy, acu...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nirankar Singh Neki, Jaswinder Singh Tags: Poster Abstract Presentations Source Type: research