Renal Sympathetic Denervation in Patients with Resistant Hypertension: A Feasibility Study
Conclusion: The Iberis system is safe and effective in patients for the treatment of resistant hypertension. Furthermore, our results suggest that we can estimate the effect of RDN in the long term at the 1-month follow-up point using the 24-h SBP.Pulse 2018;6:137 –143 (Source: Pulse)
Source: Pulse - July 25, 2018 Category: Cardiology Source Type: research

Comparative Assessment of Cutoffs for the Cardio-Ankle Vascular Index and Brachial-Ankle Pulse Wave Velocity in a Nationwide Registry: A Cardiovascular Prognostic Coupling Study
Pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) are measurements of arterial stiffness and are widely used as indices of arteriosclerosis. In Japan, brachial-ankle PWV (baPWV) is generally used to measure PWV, and while the reference value for this parameter is specified in Japanese guidelines for the noninvasive vascular function test, the CAVI reference value has not been standardized. We measured CAVI in 4,545 patients with at least one cardiovascular risk factor, and baPWV in 1,737 of these 4,545 patients on the same day as a part of an ongoing nationwide registry. The association between CAVI and baPW...
Source: Pulse - July 24, 2018 Category: Cardiology Source Type: research

Obstructive Sleep Apnea Is Closely Related to Cardiovascular Risk Factors, but Not to Clinical Recurrence of Atrial Fibrillation after Catheter Ablation: An Analysis of Atrial Fibrillation Patients
Conclusion: This study shows that the severity of OSA is not associated with the recurrence of AF after catheter ablation in Korean patients. Treatment of OSA for the sole indication of lowering AF recurrence may need to be reconsidered.Pulse 2018;6:103 –111 (Source: Pulse)
Source: Pulse - July 18, 2018 Category: Cardiology Source Type: research

Methods of Blood Pressure Assessment Used in Milestone Hypertension Trials
In the present review, we summarized the blood pressure (BP) measurement protocols of contemporary outcome trials in hypertension. In all these trials, clinic BP was used for the diagnosis and therapeutic monitoring of hypertension. In most trials, BP was measured in the sitting position with mercury sphygmomanometers or automated electronic BP monitors by trained observers. BP readings were taken on each occasion at least twice with a 30-to-60-s interval after 5 min of rest. Details regarding the arm side, cuff size, and the timing of BP measurement were infrequently reported. If clinic BP continues being used in future h...
Source: Pulse - July 18, 2018 Category: Cardiology Source Type: research

Dietary Sodium Intake and Serum Uric Acid: A Mini-Review
The aim of the present review is to summarize recent studies on the relationship between dietary sodium intake and serum uric acid concentration. In short-term dietary sodium intervention studies, including a recent further analysis of a previously published trial, high dietary sodium intake (200 mmol/day), compared with a low sodium diet (20 –60 mmol/day), resulted in a significant reduction in serum uric acid, being approximately 20–60 μmol/L. This finding, though consistent across short-term studies, is in contradiction to the long-term observational evidence on the relationship between dietary sodium int...
Source: Pulse - July 18, 2018 Category: Cardiology Source Type: research

The Pulse of Asia 2018 Kyoto
Pulse 2018;6:32 –97 (Source: Pulse)
Source: Pulse - May 29, 2018 Category: Cardiology Source Type: research

Evaluation of Central Blood Pressure in an Asian Population: Comparison between Brachial Oscillometry and Radial Tonometry Methods
Conclusion: Central SBP estimated using brachial oscillometry was similar to that estimated from radial tonometry in a Japanese population.Pulse 2018;6:98 –102 (Source: Pulse)
Source: Pulse - May 29, 2018 Category: Cardiology Source Type: research

High-Intensity Statin Therapy Is “Too Much,” Thus Not Indicated for Very Elderly Patients
Conclusion: The efficacy of statins in LDL reduction was similar between the elderly and very elderly population. However, the benefit of moderate- to high-intensity statins is limited considering potential ADR. Therefore, the stepwise intensification of statin therapy might be necessary for the very elderly in spite of the higher cardiovascular risk.Pulse 2018;6:19 –31 (Source: Pulse)
Source: Pulse - April 12, 2018 Category: Cardiology Source Type: research

Erratum
Pulse 2017;5:6 –6 (Source: Pulse)
Source: Pulse - March 2, 2018 Category: Cardiology Source Type: research

Contents Vol. 5
Pulse 2017;5:I –III (Source: Pulse)
Source: Pulse - March 2, 2018 Category: Cardiology Source Type: research

Evaluation of the Accuracy of a New Cuffless Magnetoplethysmography Blood Pressure Monitor in Hypertensive Patients
Conclusion: Although the performance of the new MPG monitor was comparable to that of the reference monitors used in this study, improved stability and accuracy are necessary for accurate BP evaluation during dynamic activity.Pulse 2018;6:9-18 (Source: Pulse)
Source: Pulse - February 14, 2018 Category: Cardiology Source Type: research

Correlation between B-Type Natriuretic Peptide and N-Terminal pro-B-Type Natriuretic Peptide in a Large Japanese Population at Risk of Stage A Heart Failure
Conclusion: In a large Japanese population at risk of stage A heart failure, there was a significant association between BNP and NT-proBNP after adjustment and stratification by demographics.Pulse 2018;6:1 –8 (Source: Pulse)
Source: Pulse - February 9, 2018 Category: Cardiology Source Type: research

Validation of a Piezoelectric Sensor Array-Based Device for Measurement of Carotid-Femoral Pulse Wave Velocity: The Philips Prototype
Conclusions: Compared with the Complior device, the Philips prototype had similar accuracy, determinants, and reproducibility in measuring PWV.Pulse 2017;5:161 –168 (Source: Pulse)
Source: Pulse - February 8, 2018 Category: Cardiology Source Type: research

Increase in the Arterial Velocity Pulse Index of Patients with Peripheral Artery Disease
Conclusion: Possible presence of PAD must be taken into account while applying the AVI for the assessment of vascular damage.Pulse 2017;5:154 –160 (Source: Pulse)
Source: Pulse - February 6, 2018 Category: Cardiology Source Type: research

The Role of Vascular Calcification in Heart Failure and Cognitive Decline
Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pa...
Source: Pulse - December 15, 2017 Category: Cardiology Source Type: research

Association of Haemodynamic Indices of Central and Peripheral Pressure with Subclinical Target Organ Damage
Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established.Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 &plusm...
Source: Pulse - November 24, 2017 Category: Cardiology Source Type: research

Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain
Background: Vascular aging may cause cerebral microvascular damage and cognitive dysfunction. There is incremental evidence that consistently implicates arterial stiffness being involved in the manifestation of cognitive impairment in the elderly. However, few investigations have examined the relationship between arterial stiffness and cognitive impairment in midlife.Summary: Past studies inconsistently showed improved cognitive outcomes after antihypertensive therapy in elderly populations. Nevertheless, recent findings revealed that blood-pressure-lowering treatment in young adults might eliminate or halt the progression...
Source: Pulse - October 26, 2017 Category: Cardiology Source Type: research

Various Indices of Arterial Stiffness: Are They Closely Related or Distinctly Different?
Arterial stiffness is an independent risk factor for cardiovascular disease. There are a number of techniques and devices that have been developed and utilized to capture the information pertaining to the elasticity of the blood vessel. Almost all the available indices of arterial stiffness are known to increase with advancing age and are elevated in the presence of hypertension and coronary heart disease. It is not known how closely these different measures of arterial stiffness are related to each other. Available evidence indicates that arterial stiffness indices that share a homogeneous methodology appear to demonstrat...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

The Pulse of Asia 2017 Taipei. May 5-6, 2017, Taipei, Taiwan: Abstracts
Pulse 2017;5:7-81 (Source: Pulse)
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Enhanced Aortic Pressure Wave Reflection in Patients with Aortic Coarctation after Aortic Arch Repair
Background: In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop.Summary: We studied the pressure waveform in patients after aortic arch repair focusing on a pressure wave reflection. In patients after aortic arch repair, the repaired portion generates a new reflected pressure wave. As a result, the newly generated pressure wave causes aortic pressure augmentation, loss of pressure amplification, and left ventricular hypertrophy with fibrosis. Balloon dilatation of the aortic arch may also generate a new pressure wave reflection.Key M...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Associations between Type 2 Diabetes Mellitus and Arterial Stiffness: A Prospective Analysis Based on the Maine-Syracuse Study
Background: The aim of this study was to investigate prospective associations between type 2 diabetes mellitus status and the gold standard non-invasive method for ascertaining arterial stiffness, carotid femoral pulse wave velocity.Methods: The prospective analysis employed 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study. Pulse wave velocity at wave 7 (2006-2010) was compared between those with type 2 diabetes mellitus at wave 6 (2001-2006) (n = 52) and non-diabetics at wave 6 (n = 456), with adjustment for demographic factors, cardiovascular risk factors and l...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Options for Dealing with Pressure Dependence of Pulse Wave Velocity as a Measure of Arterial Stiffness: An Update of Cardio-Ankle Vascular Index (CAVI) and CAVI0
Pulse wave velocity (PWV), a marker of arterial stiffness, is known to change instantaneously with changes in blood pressure. In this mini-review, we discuss two main approaches for handling the blood pressure dependence of PWV: (1) converting PWV into a pressure-independent index, and (2) correcting PWV per se for the pressure dependence. Under option 1, we focus on cardio-ankle vascular index (CAVI). CAVI is essentially a form of stiffness index β - CAVI is estimated for a (heart-to-ankle) trajectory, whereas β is estimated for a single artery from pressure and diameter measurements. Stiffness index β, and...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Lower Heart Rate Variability Is Associated with Lower Pulse Pressure Amplification: Role of Obesity
Conclusion: Larger controlled studies are needed to provide a more detailed insight into the relation between HRV and pulse pressure amplification and to determine which pathways are differentially activated in lean and obese subjects.Pulse 2017;5:99-105 (Source: Pulse)
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Logical Management of Aortic Coarctation
Pulse 2017;5:115-116 (Source: Pulse)
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Aortic-Brachial Pulse Wave Velocity Ratio: A Measure of Arterial Stiffness Gradient Not Affected by Mean Arterial Pressure
Background: Aortic stiffness, measured by carotid-femoral pulse wave velocity (cf-PWV), is used for the prediction of cardiovascular risk. This mini-review describes the nonlinear relationship between cf-PWV and operational blood pressure, presents the proposed methods to adjust for this relationship, and discusses a potential place for aortic-brachial PWV ratio (a measure of arterial stiffness gradient) as a blood pressure-independent measure of vascular aging.Summary: PWV is inherently dependent on the operational blood pressure. In cross-sectional studies, PWV adjustment for mean arterial pressure (MAP) is preferred, bu...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Heart Rate Variability and Pulse Pressure Amplification: Lessons from Diabetic Patients
Pulse 2017;5:125-126 (Source: Pulse)
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain?
Background: Vascular aging may cause cerebral microvascular damage and cognitive dysfunction. There is incremental evidence that consistently implicates arterial stiffness being involved in the manifestation of cognitive impairment in the elderly. However, few investigations have examined the relationship between arterial stiffness and cognitive impairment in midlife.Summary: Past studies inconsistently showed improved cognitive outcomes after antihypertensive therapy in elderly populations. Nevertheless, recent findings revealed that blood-pressure-lowering treatment in young adults might eliminate or halt the progression...
Source: Pulse - October 25, 2017 Category: Cardiology Source Type: research

Heart Rate Variability and Pulse Pressure Amplification: Lessons from Diabetic Patients
Pulse 2017;5:125-126 (Source: Pulse)
Source: Pulse - October 24, 2017 Category: Cardiology Source Type: research

Aortic-Brachial Pulse Wave Velocity Ratio: A Measure of Arterial Stiffness Gradient Not Affected by Mean Arterial Pressure
Background: Aortic stiffness, measured by carotid-femoral pulse wave velocity (cf-PWV), is used for the prediction of cardiovascular risk. This mini-review describes the nonlinear relationship between cf-PWV and operational blood pressure, presents the proposed methods to adjust for this relationship, and discusses a potential place for aortic-brachial PWV ratio (a measure of arterial stiffness gradient) as a blood pressure-independent measure of vascular aging.Summary: PWV is inherently dependent on the operational blood pressure. In cross-sectional studies, PWV adjustment for mean arterial pressure (MAP) is preferred, bu...
Source: Pulse - October 18, 2017 Category: Cardiology Source Type: research

Logical Management of Aortic Coarctation
Pulse 2017;5:115-116 (Source: Pulse)
Source: Pulse - September 26, 2017 Category: Cardiology Source Type: research

Options for Dealing with Pressure Dependence of Pulse Wave Velocity as a Measure of Arterial Stiffness: An Update of Cardio-Ankle Vascular Index (CAVI) and CAVI < sub > 0 < /sub >
Pulse wave velocity (PWV), a marker of arterial stiffness, is known to change instantaneously with changes in blood pressure. In this mini-review, we discuss two main approaches for handling the blood pressure dependence of PWV: (1) converting PWV into a pressure-independent index, and (2) correcting PWV per se for the pressure dependence. Under option 1, we focus on cardio-ankle vascular index (CAVI). CAVI is essentially a form of stiffness index β - CAVI is estimated for a (heart-to-ankle) trajectory, whereas β is estimated for a single artery from pressure and diameter measurements. Stiffness index β, and...
Source: Pulse - September 6, 2017 Category: Cardiology Source Type: research

Lower Heart Rate Variability Is Associated with Lower Pulse Pressure Amplification: Role of Obesity
Conclusion: Larger controlled studies are needed to provide a more detailed insight into the relation between HRV and pulse pressure amplification and to determine which pathways are differentially activated in lean and obese subjects.Pulse 2017;5:99-105 (Source: Pulse)
Source: Pulse - September 6, 2017 Category: Cardiology Source Type: research

Associations between Type 2 Diabetes Mellitus and Arterial Stiffness: A Prospective Analysis Based on the Maine-Syracuse Study
Background: The aim of this study was to investigate prospective associations between type 2 diabetes mellitus status and the gold standard non-invasive method for ascertaining arterial stiffness, carotid femoral pulse wave velocity.Methods: The prospective analysis employed 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study. Pulse wave velocity at wave 7 (2006-2010) was compared between those with type 2 diabetes mellitus at wave 6 (2001-2006) (n = 52) and non-diabetics at wave 6 (n = 456), with adjustment for demographic factors, cardiovascular risk factors and l...
Source: Pulse - August 25, 2017 Category: Cardiology Source Type: research

Enhanced Aortic Pressure Wave Reflection in Patients with Aortic Coarctation after Aortic Arch Repair
Background: In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop.Summary: We studied the pressure waveform in patients after aortic arch repair focusing on a pressure wave reflection. In patients after aortic arch repair, the repaired portion generates a new reflected pressure wave. As a result, the newly generated pressure wave causes aortic pressure augmentation, loss of pressure amplification, and left ventricular hypertrophy with fibrosis. Balloon dilatation of the aortic arch may also generate a new pressure wave reflection.Key M...
Source: Pulse - August 10, 2017 Category: Cardiology Source Type: research

Various Indices of Arterial Stiffness: Are They Closely Related or Distinctly Different?
Arterial stiffness is an independent risk factor for cardiovascular disease. There are a number of techniques and devices that have been developed and utilized to capture the information pertaining to the elasticity of the blood vessel. Almost all the available indices of arterial stiffness are known to increase with advancing age and are elevated in the presence of hypertension and coronary heart disease. It is not known how closely these different measures of arterial stiffness are related to each other. Available evidence indicates that arterial stiffness indices that share a homogeneous methodology appear to demonstrat...
Source: Pulse - May 2, 2017 Category: Cardiology Source Type: research

The Pulse of Asia 2017 Taipei. May 5-6, 2017, Taipei, Taiwan: Abstracts
Pulse 2017;5:7-81 (Source: Pulse)
Source: Pulse - May 2, 2017 Category: Cardiology Source Type: research

Various Indices of Arterial Stiffness: Are They Closely Related or Distinctly Different
Arterial stiffness is an independent risk factor for cardiovascular disease. There are a number of techniques and devices that have been developed and utilized to capture the information pertaining to the elasticity of the blood vessel. Almost all the available indices of arterial stiffness are known to increase with advancing age and are elevated in the presence of hypertension and coronary heart disease. It is not known how closely these different measures of arterial stiffness are related to each other. Available evidence indicates that arterial stiffness indices that share a homogeneous methodology appear to demonstrat...
Source: Pulse - April 11, 2017 Category: Cardiology Source Type: research

Contents Vol. 4, 2016
Pulse 2016;4:I-IV (Source: Pulse)
Source: Pulse - January 12, 2017 Category: Cardiology Source Type: research

Title Page / Table of Contents
Pulse 2016;4(suppl 1):I-IV (Source: Pulse)
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

Clinical Application of the Cardio-Ankle Vascular Index in Asymptomatic Healthy Koreans
Background: Arterial stiffness has been established as a surrogate marker for the prognosis of cardiovascular disease. Arterial stiffness is also a predictor of future cardiovascular events, and is the earliest detectable manifestation of adverse structural and functional changes to blood vessel walls.Summary and Key Messages: The cardio-ankle vascular index (CAVI) is an index representing the stiffness of the entire arterial segments from the aorta to the ankle independent of the blood pressure at the time of the measurement. This paper provides an overview of the clinical application of arterial stiffness measurement by ...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

Protocol for Evaluating the Cardio-Ankle Vascular Index to Predict Cardiovascular Events in Japan: A Prospective Multicenter Cohort Study
The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients.Methods and Design: This prospective multicenter study to evaluate the usefulness of the CAVI to predict cardiovascular events in Japan (CAVI-J) is a cohort study with central registration. Participants (n = 3,000) will be scheduled to enroll and data will be collected for up to 5 years from entry of participants into the study. To be eligible to participate in the CAVI-J study, individuals have to be aged between 40 and 74 years and have at least one of the following risk factors for arterios...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

Cardio-Ankle Vascular Index in a Thai Population
Arterial stiffness as measured by the cardio-ankle vascular index (CAVI) is a widely available method in Thailand. Data from a large cross-sectional study revealed a significant correlation of CAVI and the presence of coronary artery disease as detected from 64-slice coronary computed tomography arteriography. Futhermore, CAVI was shown to predict long-term cardiovascular events in the patients with intermediate cardiovascular risk.Pulse 2016;4(suppl 1):8-10 (Source: Pulse)
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

Arterial Stiffness: Recommendations and Standardization
The use of arterial stiffness measurements in longitudinal cohorts of normal populations, hypertensive patients, diabetic patients, healthy elderly, and patients on hemodialysis have confirmed the value of this important measure of arterial health, and established its complementary role to measures of blood pressure. Its contribution to understanding cardiovascular and mortality risk beyond blood pressure measurements has moved measures of arterial stiffness into the ranks of factors such as elevated cholesterol, diabetes, and left ventricular hypertrophy in considering cardiovascular risk. The recent international collabo...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

New Epoch for Arterial Stiffness Measurement in the Clinic
Pulse 2016;4(suppl 1):1-2 (Source: Pulse)
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness
Conclusions: Although skin and plasma AGEs were similarly associated with gender and diabetes or prediabetes, they might measure something different and have different clinical relevance, such as for arterial stiffness.Pulse 2016;4:208-218 (Source: Pulse)
Source: Pulse - December 21, 2016 Category: Cardiology Source Type: research

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes
There is a plausible physiological theory, supported by many observational studies, that vitamin D supplementation should be effective for improving cardiovascular end points, such as blood pressure (BP), large artery stiffness, atherosclerosis, endothelial function and clinical events. However, results from randomised controlled trials (RCTs) have been inconsistent. In this review, we evaluated the evidence regarding the effectiveness of vitamin D supplementation for cardiovascular surrogate and hard clinical end points. RCTs were assessed in terms of sample size, duration of supplementation, baseline vitamin D level incl...
Source: Pulse - December 8, 2016 Category: Cardiology Source Type: research

Cardiovascular Effects of Long-Term Vitamin D Supplementation: Summarised by Many but Studied by Few
Pulse 2016;4:172-174 (Source: Pulse)
Source: Pulse - December 7, 2016 Category: Cardiology Source Type: research

Large Artery Stiffness Assessment Using SphygmoCor Technology
This article briefly describes these parameters related to large artery stiffness and provides reference to validation and repeatability studies relative to the clinical use of the SphygmoCor devices. It is beyond the scope to review here the 424 original research articles that have employed SphygmoCor devices in measuring arterial stiffness. Instead, the method of measurement across the devices is described, including tonometry, volumetric displacement through cuff placement around limbs, and ambulatory monitoring. Key population and subpopulation studies are cited where the average stiffness parameter progression with ag...
Source: Pulse - November 30, 2016 Category: Cardiology Source Type: research

Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure
In a recently published paper, Greve et al [J Hypertens 2016;34:1279-1289] investigate whether the estimated carotid-femoral pulse wave velocity (ePWV), calculated using an equation derived from the relationship between carotid-femoral pulse wave velocity (cfPWV), age, and blood pressure, predicts cardiovascular disease (CVD) as good as the measured cfPWV. Because ePWV predicts CVD as good as cfPWV, some might wonder whether ePWV could be replaced by cfPWV, which is a time-consuming measurement requiring an expensive apparatus. This question is addressed in this mini-review.Pulse 2016;4:175-179 (Source: Pulse)
Source: Pulse - November 30, 2016 Category: Cardiology Source Type: research

Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study
Conclusion: The findings of the present study suggest that polymorphism in the C148T position of the β-fibrinogen gene might be a risk factor for IS mainly for the small vessel disease stroke subtype in a North Indian population. Further, large prospective studies are required to confirm these findings.Pulse 2016;4:165-171 (Source: Pulse)
Source: Pulse - October 11, 2016 Category: Cardiology Source Type: research