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Condition: Metabolic Syndrome
Drug: Insulin

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Total 230 results found since Jan 2013.

The Global Epidemic of the Metabolic Syndrome
AbstractMetabolic syndrome, variously known also as syndrome X, insulin resistance, etc., is defined by WHO as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Though there is some variation in the definition by other health care organization, the differences are minor. With the successful conquest of communicable infectious diseases in most of the world, this new non-communicable disease (NCD) has become the major health hazard of modern world. Though it started in the Western world, with the spread of the Western lifestyle across the globe, it has become now...
Source: Current Hypertension Reports - February 26, 2018 Category: Primary Care Source Type: research

Epicardial adipose tissue and metabolic syndrome: An update protocol for systematic review and meta-analysis
Conclusion: This systematic review will provide evidence to assess whether there is a strong association of EAT and MetS, and its components.
Source: Medicine - April 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis
Conclusions: Our results indicate that MBS is a risk factor for psoriasis patients with advanced age. The relationship between disease severity and obesity, diabetes, and smoking in psoriasis patients indicates that the patients should be informed about the potential metabolic risks and receive therapies for behavioral changes besides anti-psoriatic treatment in order to minimize these risks.
Source: Anais Brasileiros de Dermatologia - May 3, 2018 Category: Dermatology Source Type: research

Metabolites in visceral fat: useful signals of metabolic syndrome?
Metabolic syndrome comprises a series of health conditions, such as increased blood pressure, high blood sugar, excess abdominal fat, and altered circulating cholesterol or triglyceride levels. A fast growing number of affected individuals are at an increased risk of heart disease, stroke and type-2 diabetes. Obesity, especially build-up of visceral fat, is a recognized major risk factor for the development of metabolic syndrome. However, our understanding of the mechanistic links and biomarkers that associate visceral fat with the development of conditions underlying metabolic syndrome is still inadequate. In a recent pap...
Source: Biochemical Journal - May 31, 2018 Category: Biochemistry Authors: Galavotti, S., Gescher, A. J., Rufini, A. Tags: Commentaries Source Type: research

Uric acid and cardiovascular disease.
Abstract Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of them suggested the existence of an association between elevated serum UA level and CVD...
Source: International Journal of Clinical Chemistry - May 24, 2018 Category: Chemistry Authors: Ndrepepa G Tags: Clin Chim Acta Source Type: research

Uric acid and cardiovascular disease
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Gjin Ndrepepa Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of them ...
Source: Clinica Chimica Acta - June 2, 2018 Category: Laboratory Medicine Source Type: research

High-density lipoprotein-cholesterol functionality and metabolic syndrome: Protocol for review and meta-analysis
Introduction: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver. As one of the key functions of HDL, their hypothesis was tha...
Source: Medicine - June 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Uric acid and cardiovascular disease
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Gjin NdrepepaAbstractUric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of ...
Source: Clinica Chimica Acta - July 5, 2018 Category: Laboratory Medicine Source Type: research

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary.
Authors: Raskin P, Cincotta AH Abstract An extended series of studies indicate that endogenous phase shifts in circadian neuronal input signaling to the biological clock system centered within the hypothalamic suprachiasmatic nucleus (SCN) facilitates shifts in metabolic status. In particular, a diminution of the circadian peak in dopaminergic input to the peri-SCN facilitates the onset of fattening, insulin resistance and glucose intolerance while reversal of low circadian peak dopaminergic activity to the peri-SCN via direct timed dopamine administration to this area normalizes the obese, insulin resistant, gluco...
Source: Expert Review of Endocrinology and Metabolism - August 2, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links.
Authors: Zafar U, Khaliq S, Ahmad HU, Manzoor S, Lone KP Abstract Metabolic syndrome (MetS), today a major global public health problem, is a cluster of clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension, insulin resistance, and dyslipidemias. These MetS-related traits significantly increase the risk of type 2 diabetes mellitus, adverse cardiac events, stroke, and hepatic steatosis. The pathogenesis of MetS is multifactorial, with the interplay of environmental, nutritional, and genetic factors. Chronic low-grade inflammation together with visceral adipose tissue, adipocyte ...
Source: Hormones - September 2, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
ConclusionOur approach identifies salient T2D genetically anchored and physiologically informed pathways, and supports the use of genetics to deconstruct T2D heterogeneity. Classification of patients by these genetic pathways may offer a step toward genetically informed T2D patient management.
Source: PLoS Medicine - September 21, 2018 Category: Internal Medicine Authors: Miriam S. Udler Source Type: research

A clinical review of the effectiveness of tomato (Solanum lycopersicum) against cardiovascular dysfunction and related metabolic syndrome
In conclusion, consuming fresh tomato supplements may contribute to the prevention of obesity, diabetes and cardiovascular dysfunctions through positively affecting biochemical pathways associated with these conditions.
Source: Journal of Herbal Medicine - October 5, 2018 Category: Complementary Medicine Source Type: research

Chronic kidney disease among US adults with type 2 diabetes and cardiovascular diseases: A national estimate of prevalence by KDIGO 2012 classification
ConclusionsThis study confirms the high prevalence of CKD in patients with multiple comorbidities: T2D and CVD. It also provides estimates of the prevalence of CKD categories based on KDIGO 2012 classification for US adults with T2D.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 3, 2018 Category: Endocrinology Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research