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Condition: Heatstroke

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Total 1318 results found since Jan 2013.

Effects of heat stroke on surface ECG: a study on clinical outcomes
Conclusion There was high incidence of atrial arrhythmias in patients with classic heat stroke. A low P-wave voltage (<0.01 mV) in lead II was predictive of adverse in-hospital outcome in this cohort of patients.
Source: Heart Asia - June 19, 2019 Category: Cardiology Authors: Paul, A., Alex, R., Jacob, J. R., Yadav, B. Tags: Original research Source Type: research

Bilateral hippocampal hyperintensity and elevated cardiac enzyme levels due to exertional heat stroke: A case report
We report a 12 year-old child who suffered from heat stroke with elevated cardiac enzymes with normal cardiac function and special magnetic resonance imaging (MRI) finding.
Source: Journal of Acute Medicine - March 10, 2015 Category: Emergency Medicine Source Type: research

Cooling Methods in Heat Stroke
Heat stroke is an illness with a high risk of mortality or morbidity, which can occur in the young and fit (exertional heat stroke) as well as the elderly and infirm (nonexertional heat stroke). In the United States, from 2006 to 2010, there were at least 3332 deaths attributed to heat stroke.
Source: The Journal of Emergency Medicine - October 31, 2015 Category: Emergency Medicine Authors: Flavio G. Gaudio, Colin K. Grissom Tags: Clinical Review Source Type: research

Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage.
This study was performed by using the characteristic high lethality rate and sepsis-mimic systemic inflammatory response of a murine model of heat stroke to test our hypothesis that supra-physiological doses of ascorbate may have therapeutic use in critical care. We demonstrated that parenteral administration of ascorbate abrogated the lethality and thermoregulatory dysfunction in murine model of heat stroke by attenuating heat stroke-induced accelerated systemic inflammatory, coagulation responses and the resultant multiple organ injury, especially in hypothalamus. Overall, our findings support the hypothesis and notion t...
Source: Free Radical Biology and Medicine - December 15, 2015 Category: Biology Authors: Chang CY, Chen JY, Chen SH, Cheng TJ, Lin MT, Hu ML Tags: Free Radic Biol Med Source Type: research

Fatal heat stroke in children found in parked cars: autopsy findings
Conclusion: Typical autopsy findings following classical heat stroke in children include diffuse petechiae and hemorrhages and lung involvement. These findings are similar to those reported in adults that had died following exertional heat stroke—a very different mechanism of heat accumulation. Prevention of future events can possibly be obtained by public education on the rapid heating of closed vehicles, the vulnerability of children to heat, and the caregiver role in child entrapment. What is Known: ...
Source: European Journal of Pediatrics - July 19, 2016 Category: Pediatrics Source Type: research

Heat Stroke Leading to Acute Liver Injury & Failure: A Case Series from the Acute Liver Failure Study Group
ConclusionsManagement of ALI and ALF secondary to heat stroke should focus on cooling protocols and supportive care, with consideration of liver transplantation in refractory patients.This article is protected by copyright. All rights reserved.
Source: Liver International - January 26, 2017 Category: Gastroenterology Authors: Brian C. Davis, Holly Tillman, Raymond T. Chung, R. Todd Stravitz, K. Rajender Reddy, Robert J. Fontana, Brendan McGuire, Timothy Davern, William M. Lee, Tags: Rapid Communication Source Type: research

Unique cytokine and chemokine responses to exertional heat stroke in mice
In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at maximum core temperature (Tc,max) that peaked at 0.5 h of recovery and disappeared by 3 h. IL-10 was not elevated at any time. This contrasts with PHS where both IL-6 and IL-10 peak at 3 h of recovery. Keratinocyte chemoattractant (KC), granulocyte-colony-stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-2, MIP-1β, and monocyte chemoattractive factor-1 also demonstrated near peak response...
Source: Journal of Applied Physiology - February 2, 2017 Category: Physiology Authors: King, M. A., Leon, L. R., Morse, D. A., Clanton, T. L. Tags: RESEARCH ARTICLE Source Type: research

Superhero Joey: Five-year-old fights moyamoya disease
It’s been said that not all heroes wear capes — but Joey Gallagher owns several. The five-year-old has already amassed a collection of superhero gear, from a Superman Halloween costume to a t-shirt emblazoned with the Batman logo. Yet even the most diehard comic book fan would likely admit that feats like flying, leaping tall buildings and fighting bad guys don’t hold a candle to the challenges this little boy has already surmounted. Just last June, Joey was out of town with his family when he had what his parents, Leila and Scott, feared was a seizure. Clinicians in the emergency department dismissed the event as he...
Source: Thrive, Children's Hospital Boston - April 4, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories childhood stroke Dr. Edward Smith Dr. Michael Scott moyamoya Moyamoya Disease Program Source Type: news

Could your tattoos put you at risk of heat stroke?
Conclusion The study showed that artificially stimulating sweat glands in a tattooed area of skin in 10 men produced a lower sweat rate than stimulating sweat glands in a non-tattooed area of skin in the same person. The authors suggest a number of possible explanations for this, including that it may be because tattooing skin starts an inflammatory response that may cause damage to normal tissue including sweat glands. However, these are only theories and need to be investigated further. While this is interesting preliminary research, there are some important things to remember: There were only 10 male participants invo...
Source: NHS News Feed - April 13, 2017 Category: Consumer Health News Tags: Lifestyle/exercise Source Type: news

Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
Authors: Chen F, Li H, Zhu G, Chen X, Tang Z Abstract The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS. In the HS groups, the ra...
Source: Molecular Medicine Reports - May 13, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Transcriptome Sequencing Reveals Astrocytes as a Therapeutic Target in Heat-Stroke
AbstractHeat-stroke is a serious form of hyperthermia with high mortality, and can induce severe central nervous system disorders. The neurovascular unit (NVU), which consists of vascular cells, glial cells, and neurons, controls blood-brain barrier (BBB) permeability and cerebral blood flow, and maintains the proper functioning of neuronal circuits. However, the detailed function of each BBB component in heat-stroke remains unknown. In order to interpret alterations caused by heat stress, we performed transcriptome comparison of neuron and astrocyte primary cultures after heat treatment. Differentially-expressed genes wer...
Source: Neuroscience Bulletin - July 11, 2017 Category: Neuroscience Source Type: research

Feasibility and Safety of Intravascular Temperature Management for Severe Heat Stroke: A Prospective Multicenter Pilot Study
This study evaluated the efficacies of conventional treatment with or without intravascular temperature management for severe heat stroke. Design: Prospective multicenter study. Setting: Critical care and emergency medical centers at 10 tertiary hospitals. Patients: Patients with severe heat stroke hospitalized during two summers. Interventions: Conventional cooling with or without intravascular temperature management. Measurements and Main Results: Cooling efficacy, Sequential Organ Failure Assessment score, occurrence rate of serious adverse events, and prognosis based on the modified Rankin Scale and Cere...
Source: Critical Care Medicine - June 16, 2018 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Therapeutic Hypothermia Protects Against Heat Stroke-Induced Arterial Hypotension via Promoting Left Ventricular Performance in Rats.
Authors: Ko WC, Lin CH, Lee JJ, Chang CP, Chao CM Abstract We aimed to ascertain whether therapeutic hypothermia (TH) acts as cardioprotective management for heat stroke (HS). Adult male rats under general anesthesia were exposed to whole-body heating (43°C for 70 min) to induce HS. Rats with HS displayed hyperthermia (core body temperature 42°C vs. 36°C); hypotension (30 mmHg vs. 90 mmHg mean arterial blood pressure); suppressed left ventricular (LV) performance (stroke volume 52 μl/min vs. 125 μl/min), ejection fraction (0.29% vs. 0.69%), relaxation factor (72 ms vs. 12 ms), and arterial elastance (0.31 mmHg...
Source: International Journal of Medical Sciences - March 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Neural Tract Injuries Revealed by Diffusion Tensor Tractography in a Patient With Severe Heat Stroke
Neurologic sequelae of heat stroke are prevalent among patients with severe heat stroke who require admission to an intensive care unit. Radiologic diagnosis of the condition is challenging because not every patient with clinical deficits shows abnormalities in computed tomography or magnetic resonance imaging. In this case review, we report a patient who had been diagnosed with a severe heat stroke and showed gait disturbance, language disorder, and cognitive impairment although conventional magnetic resonance imaging did not reveal significant findings that correlated with his symptoms. Diffusion tensor tractography has ...
Source: American Journal of Physical Medicine and Rehabilitation - July 30, 2020 Category: Rehabilitation Tags: Case Reports Source Type: research

Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China
This article aims to interpret and supplement the major updates to the new consensus.
Source: Military Medical Research - August 5, 2020 Category: International Medicine & Public Health Source Type: research