• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Molecular imaging of inflammation in the brain-heart axis after ischemic stroke: comparison of two murine stroke models.
Conclusions: In contrast to topical ET-1 application after craniotomy, the intravascular MCAo model enables imaging studies of brain-heart networking after stroke, which evokes elevated TSPO PET signal in both brain and heart. The severity of cerebral ischemic damage may contribute to cardiac dysfunction via systemic inflammatory networking.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Hermanns, N., Bascunana, P., Langer, B. L. N., Wolf, B., Bankstahl, J., Ross, T., Bengel, F., Thackeray, J. Tags: Cardiovascular Council YIA Symposium Source Type: research

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study
CONCLUSIONS: Available genetic data do not support substantial effects of cardiac traits on the risk of stroke beyond known clinical risk factors. Our findings highlight the need to carefully control for confounding and other potential biases in studies examining candidate cardiac risk factors for stroke.PMID:34911345 | DOI:10.1161/STROKEAHA.121.036306
Source: Atherosclerosis - December 16, 2021 Category: Cardiology Authors: Simon Frerich Rainer Malik Marios K Georgakis Moritz F Sinner Steven J Kittner Braxton D Mitchell Martin Dichgans Source Type: research

Identification of magnetic resonance imaging features for the prediction of unrecognized atrial fibrillation in acute ischemic stroke
Conclusion Initial MRI at the time of stroke may be useful to predict which patients have cardioembolic stroke caused by unrecognized AF. Further studies are warranted to verify these findings and their application to high-risk patients.
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research

Effect of Remote Ischemic Conditioning in Patients With Takotsubo Syndrome After Acute Stroke: Study Protocol for a Randomized Controlled Trial
This study has been approved by the Medical Ethics Committee of Xuanwu Hospital, Capital Medical University ([2017] 072). The study findings will be presented at international conferences and published in a peer-reviewed journal.Trial registration: This study has been prospectively registered in the Chinese Clinical Trial Registry on September 10, 2018 (ChiCTR1800018290).
Source: Frontiers in Neurology - April 27, 2020 Category: Neurology Source Type: research

Acute Heart Failure After Reperfused Ischemic Stroke: Association With Systemic and Cardiac Inflammatory Responses
Patients with acute ischemic stroke (AIS) present an increased incidence of systemic inflammatory response syndrome and release of Troponin T coinciding with cardiac dysfunction. The nature of the cardiocirculatory alterations remains obscure as models to investigate systemic interferences of the brain-heart-axis following AIS are sparse. Thus, this study aims to investigate acute cardiocirculatory dysfunction and myocardial injury in mice after reperfused AIS. Ischemic stroke was induced in mice by transient right-sided middle cerebral artery occlusion (tMCAO). Cardiac effects were investigated by electrocardiograms, 3D-e...
Source: Frontiers in Physiology - December 21, 2021 Category: Physiology Source Type: research

Limitations and pitfalls in measurements of right ventricular stroke volume in an animal model of right heart failure
Right heart failure occurs in various heart and pulmonary vascular diseases and may be fatal. We aimed to identify limitations in non-invasive measurements of right ventricular stroke volume in an animal model of right ventricular failure. Data from previous studies randomising rats to pulmonary trunk banding (PTB, n = 33) causing pressure-overload right ventricular failure or sham operation ( n = 16) was evaluated retrospectively. We measured right ventricular stroke volume by high frequency echocardiography and magnetic resonance imaging (MRI). We found correlation between right ventricular stroke volume measured b...
Source: Physiological Measurement - April 9, 2015 Category: Physiology Authors: Mads Dam Vildbrad, Asger Andersen, Thomas Krarup Andersen, Sofie Axelgaard, Sarah Holmboe, Stine Andersen, Steffen Ringgaard and Jens Erik Nielsen-Kudsk Source Type: research

Stroke volume ratio derived from magnetic resonance imaging as an indicator of interventricular dyssynchrony predicts future cardiac event in patients with biventricular Fontan circulation
This study wanted to assess the hypothesis that interventricular dyssynchrony evaluated by cardiac magnetic resonance imaging (MRI) can predict future cardiac events in patients with biventricular heart who have undergone Fontan surgery. We prospectively enrolled consecutive patients with biventricular Fontan circulation from 2003 to 2016, and performed protocolized cardiac MRI. We determined the stroke volume ratio (SVr) using the following formula to assess interventricular dyssynchrony: (stroke volume (SV) of the two whole ventricles)/(SV of the right ventricle  + SV of the left ventricle), by tracing cine MRI data....
Source: Heart and Vessels - July 4, 2018 Category: Cardiology Source Type: research

Evaluation of left ventricular function in patients with acute ischaemic stroke using cine cardiovascular magnetic resonance imaging
ConclusionsCardiovascular MRI at 3  Tesla is an appropriate method for the evaluation of cardiac function in a selected cohort of patients with AIS. Systolic and diastolic dysfunction is frequent in these patients. CRT imaging allows reliable assessment of systolic and diastolic function.
Source: ESC Heart Failure - July 14, 2020 Category: Cardiology Authors: Simon Hellwig, Ulrike Grittner, Matthias Elgeti, Sebastian Wyschkon, Sebastian N. Nagel, Jochen B. Fiebach, Thomas Krause, Juliane Herm, Jan F. Scheitz, Matthias Endres, Christian H. Nolte, Karl Georg Haeusler, Thomas Elgeti Tags: Original Research Article Source Type: research

Cardiovascular Biomarkers and Subclinical Brain Disease in the Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— NT-proBNP and hs-cTnT are independently associated with silent MRI-defined BI and WML, suggesting that cardiovascular biomarkers may be useful to identify individuals with subclinical cerebral injury.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Dadu, R. T., Fornage, M., Virani, S. S., Nambi, V., Hoogeveen, R. C., Boerwinkle, E., Alonso, A., Gottesman, R. F., Mosley, T. H., Ballantyne, C. M. Tags: Risk Factors, Brain Circulation and Metabolism, Cerebral Lacunes, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Contribution Of Mitral Valve Atrioventricular Plane Displacement To The Stroke Volume In Patients With Severe Mitral Regurgitation
Introduction: Longitudinal shortening measured as atrioventricular plane displacement (AVPD) represents a piston-like movement of the base of the ventricles toward the apex during the cardiac cycle. Prior studies using echocardiography and cardiac magnetic resonance imaging demonstrated AVPD to account for a large part of the left ventricular (LV) stroke volume (SV) in athletes, healthy controls, and heart failure patients. We sought to validate the use of cardiac computed tomography (CCT) to measure the AVPD and subsequently explore the contribution of the AVPD towards overall LV SV in patients with functional and primary...
Source: Journal of Cardiovascular Computed Tomography - July 1, 2023 Category: Radiology Authors: J. Kassab, H. Layoun, J. El Dahdah, M. Chedid El Helou, S. Kapadia, S. Harb, R. Puri Source Type: research

Potential Applications of Remote Limb Ischemic Conditioning for Chronic Cerebral Circulation Insufficiency
Conclusion Due to its long-term and often invisible course, CCCI has received less attention than acute cerebral ischemic stroke. However, without appropriate intervention, CCCI may lead to a variety of adverse events. Because the pathophysiological changes associated with CCCI are complex, pharmacological research in this area has been disappointing. Recent research suggests that RLIC, which is less invasive and more well-tolerated than drug treatment, can activate endogenous protective mechanisms during CCCI. In the present report, we reviewed studies related to CCCI (Table 1), as well as those related to stroke and sta...
Source: Frontiers in Neurology - May 2, 2019 Category: Neurology Source Type: research

Preserve the Brain Primary Goal in the Therapy of Atrial Fibrillation ∗
Treatment of atrial fibrillation (AF) involves 3 major strategies: prevention of stroke, maintenance of sinus rhythm, and rate control (1). Stroke is the most dreaded complication of AF, and its prevention is key. Anticoagulation with warfarin and the newer agents dabigatran, rivaroxaban, and apixaban is highly effective in preventing strokes in patients with AF (1,2,3,4). However, defining the appropriate patient for anticoagulant therapy is not an exact science, and the stroke risk schema CHADS2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke/transient ischemic attack) and CH...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - July 29, 2013 Category: Cardiology Source Type: research

Preserve the Brain: Primary Goal in the Therapy of Atrial Fibrillation∗
Treatment of atrial fibrillation (AF) involves 3 major strategies: prevention of stroke, maintenance of sinus rhythm, and rate control . Stroke is the most dreaded complication of AF, and its prevention is key. Anticoagulation with warfarin and the newer agents dabigatran, rivaroxaban, and apixaban is highly effective in preventing strokes in patients with AF . However, defining the appropriate patient for anticoagulant therapy is not an exact science, and the stroke risk schema CHADS2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke/transient ischemic attack) and CHA2DS2-VASc (...
Source: Journal of the American College of Cardiology - May 17, 2013 Category: Cardiology Authors: Eric N. Prystowsky, Benzy J. Padanilam Tags: Heart Rhythm Disorders: Editorial Comment Source Type: research

Atrial cardiomyopathy: from cell to bedside
AbstractAtrial cardiomyopathy refers to structural and electrical remodelling of the atria, which can lead to impaired mechanical function. While historical studies have implicated atrial fibrillation as the leading cause of cardioembolic stroke, atrial cardiomyopathy may be an important, underestimated contributor. To date, the relationship between atrial cardiomyopathy, atrial fibrillation, and cardioembolic stroke remains obscure. This review summarizes the pathogenesis of atrial cardiomyopathy, with a special focus on neurohormonal and inflammatory mechanisms, as well as the role of adipose tissue, especially epicardia...
Source: ESC Heart Failure - August 3, 2022 Category: Cardiology Authors: Mengmeng Li, Yuye Ning, Gary Tse, Ardan M. Saguner, Meng Wei, John D. Day, Guogang Luo, Guoliang Li Tags: Review Source Type: research

Pages: 1  2  3  4  5  6  7  8