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Total 10881 results found since Jan 2013.

Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women
Stroke remains the leading cause of disability and mortality globally. Based on the Global Burden of Disease Study 2016, it was estimated that there were 13.7 million new stroke cases, 5.5 million deaths, 80.1 million prevalent cases, and 116.4 million disability-adjusted life-years.1 About 75% of stroke cases are ischemic, whereas the remaining cases are hemorrhagic.2 Stroke incidence increases with age. Well-known risk factors for stroke include personal history of hypertension, diabetes and cardiac diseases, unhealthy behavioral factors (heavy cigarette consumption, less physical inactivity, poor diet), and serious environmental risks.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Chuan Shao, Hui Tang, Xiaoya Wang, Jiaquan He Source Type: research

Comparative effects of intensive-blood pressure versus standard-blood pressure-lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial
Conclusion: Intensive BP lowering is associated with increased mortality in patients with severe AIS despite lowering the risk of ICH. Further randomized trials are required to provide reliable evidence over the optimum SBP target in the most serious type of AIS. Trial registration: ClinicalTrials.gov Identifier: NCT01422616.
Source: Journal of Hypertension - January 7, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

The correlation between testosterone and stroke and the mediating role of blood pressure: The Henan rural cohort study
Stroke is currently the 2nd leading global cause of death and imposes a heavy burden on socio-economic and human health.1,2 There are many factors affecting stroke, among which blood pressure (BP) plays an important role.3 Many studies have pointed to hypertension as a risk factor for stroke.4-6 A study has shown that the prevention and treatment of stroke can be achieved by appropriately lowering BP.7 Therefore, the relationship between BP and stroke is still worth elucidating.
Source: Journal of Stroke and Cerebrovascular Diseases - August 16, 2022 Category: Neurology Authors: Pengling Liu, Dandan Wei, Luting Nie, Keliang Fan, Qingqing Xu, Lulu Wang, Juan Wang, Yu Song, Mian Wang, Xiaotian Liu, Jian Hou, Songcheng Yu, Linlin Li, Chongjian Wang, Wenqian Huo, Caini Fan, Zhenxing Mao Source Type: research

Premature atherosclerosis: A major contributor to early-onset ischemic stroke
Atherosclerosis is an age-dependent process. The prevalence of large-artery atherosclerosis in case series of ischemic stroke in young adults has been substantially less than in older adults.1–4 Historically, data on the role of atherosclerosis in early-onset stroke have been limited for a variety of reasons. First, multi-institutional studies often have inconsistent evaluations of the cerebral vasculature, particularly the intracranial circulation. Second, studies may not report evidence for proximal atherosclerosis less severe than necessary to meet criteria for etiology. Emerging data, however, show a high inciden...
Source: Neurology - April 1, 2013 Category: Neurology Authors: Kittner, S. J., Singhal, A. B. Tags: Stroke in young adults, Ultrasound, Prevalence studies, Risk factors in epidemiology EDITORIALS Source Type: research

Comparison between angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers on the risk of stroke recurrence and longitudinal progression of white matter lesions and silent brain infarcts on MRI (CEREBRAL study): rationale, design, and methodology
ConclusionsOur study will clarify whether angiotensin‐converting enzyme inhibitors or angiotensin II receptor blockers are more effective for preventing primary and recurrence of ischemic stroke, including the progression of asymptomatic cerebral lesions on magnetic resonance imaging, in elderly hypertensive patients.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Shigeru Yamano, Manabu Horii, Takeshi Takami, Mio Sakuma, Takeshi Morimoto, Sadanori Okada, Toshiaki Taoka, Kimihiko Kichikawa, Hiroyuki Sasamura, Hiroshi Itoh, Yoshiko Furuya, Satoshi Ueno, Tomoaki Imamura, Seigo Sugiyama, Hisao Ogawa, Yoshihiko Saito Tags: Protocols Source Type: research

Brain damage reduced, brain hemorrhaging eliminated in rodents afflicted by stroke
An experimental drug called 3K3A-APC appears to reduce brain damage, eliminate brain hemorrhaging and improve motor skills in older stroke-afflicted mice and stroke-afflicted rats with comorbid conditions such as hypertension, according to a new study from Keck Medicine of USC. The study, which appears online in the journal Stroke, provides additional evidence that 3K3A-APC may be used as a therapy for stroke in humans, either alone or in combination with the FDA-approved clot-busting drug therapy tPA (tissue plasminogen activator)...
Source: Health News from Medical News Today - October 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Patent Foramen Ovale and Infarct Volume in Cryptogenic Stroke
Background: The causal relationship between patent foramen ovale (PFO) and stroke is controversial. We hypothesized that if PFO is a pathway of embolic source, there might be a correlation between PFO characteristics (ie, size or extent of shunt) and ischemic lesion burden (ie, infarct volume and number).Methods: From ischemic stroke patients admitted to Asan Medical Center between January 2000 and October 2007, we identified those who had (1) acute ischemic lesion on diffusion-weighted imaging within 5 days of symptom onset and (2) cryptogenic stroke and only PFO detected by transesophageal echocardiography. PFO characte...
Source: Journal of Stroke and Cerebrovascular Diseases - June 7, 2013 Category: Neurology Authors: Jin-Man Jung, Jong-Young Lee, Hye-Jin Kim, Youngrok Do, Sun U. Kwon, Jong S. Kim, Jae-Kwan Song, Dong-Wha Kang Tags: Original Articles Source Type: research

Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Conclusions— In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2–VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Roldan, V., Vilchez, J. A., Manzano-Fernandez, S., Jover, E., Galvez, J., Puche, C. M., Valdes, M., Vicente, V., Lip, G. Y. H., Marin, F. Tags: Arterial thrombosis, Coumarins, Anticoagulants Clinical Sciences Source Type: research

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals
Background: In young individuals, a genetically predisposing hypercoagulability and classic modifying risk factors can act synergistically on the ischemic stroke risk development. The aim of the study was to compare the prevalence of classic vascular risk factors and polymorphisms of the G20210A coagulation factor II (prothrombin), Arg506Glu coagulation factor V Leiden, C677T methylenetetrahydrofolate reductase (MTHFR), and 4G/5G plasminogen activator inhibitor-1 (PAI-1) and the impact of these gene mutations and classic vascular risk factors on the overall stroke risk in individuals aged 55 years or younger.Methods: The s...
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2013 Category: Neurology Authors: Visnja Supanc, Zdenko Sonicki, Ines Vukasovic, Vesna V. Solter, Iris Zavoreo, Vanja B. Kes Tags: Original Articles Source Type: research

Aspirin plus clopidogrel in acute minor ischaemic stroke or transient ischaemic attack is superior to aspirin alone for stroke risk reduction: CHANCE trial
Commentary on: Wang Y, Wang Y, Zhao X, et al.. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11–19. Context Combination therapy with aspirin added to clopidogrel has had a disappointing record in the prevention of recurrent stroke. The management of atherothrombosis with clopidogrel in high-risk patients (MATCH)1 and the secondary prevention of small subcortical strokes (SPS3)2 randomised controlled trials (RCTs) showed that combination therapy was not more effective than clopidogrel or aspirin alone, but was associated with two to three times the risk of major or ...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Gorelick, P. B., Farooq, M. U. Tags: Smoking and tobacco, Clinical trials (epidemiology), Genetics, Stroke, Hypertension, Diabetes, Health education, Smoking Therapeutics Source Type: research

Lower stroke risk with lower blood pressure in hemodynamic cerebral ischemia
Conclusion: BPs ≤130/85 mm Hg were associated with lower subsequent stroke risk in these patients. Classification of evidence: This study provides Class III evidence that control of hypertension ≤130/85 mm Hg is associated with a reduced risk of subsequent ipsilateral ischemic stroke in patients with recently symptomatic carotid occlusion and hemodynamic cerebral ischemia (increased oxygen extraction fraction).
Source: Neurology - March 24, 2014 Category: Neurology Authors: Powers, W. J., Clarke, W. R., Grubb, R. L., Videen, T. O., Adams, H. P., Derdeyn, C. P., For the COSS Investigators Tags: Stroke prevention, PET, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Cross-Border Acute Ischemic Stroke Subtype Comparison Between Hispanics and Mexican Mestizos (P1.123)
CONCLUSIONS: Small artery ischemic strokes were the most common subtype in both MM and Hispanic patients, and occurred with a similar frequency in the two populations. This similarity could be a consequence of a high pre-existing condition of hypertension in both groups. A higher incidence of large vessel and cardioembolic ischemic strokes were seen in MM compared with Hispanics, which may reflect the higher number of patients with risk factors of smoking and atrial fibrillation in the MM group.Disclosure: Dr. Cerdan-Trevino has nothing to disclose. Dr. Cantu-Martinez has nothing to disclose. Dr. Mora-Villalvazo has nothin...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Cerdan-Trevino, M., Cantu-Martinez, L., Mora-Villalvazo, R., Martinez, H., Hughes, R., Poisson, S. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Subtype Source Type: research

Troponin Elevation in Intra-arterial Stroke Intervention (P4.211)
CONCLUSIONS: Aggressive treatment may increase the risk of troponin elevation without increasing mortality in AIS patients. This finding is reassuring in view of continued interest in IA treatment of stroke in addition to tPA thrombolysis.Disclosure: Dr. Kumar has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Alawi has nothing to disclose. Dr. Michael has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kumar, A., Mehta, S., Alawi, A., Michael, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA
Conclusions PVS do not have an independent association with cognitive impairment in patients with ischaemic stroke or TIA. The associations with clinical-radiological factors are consistent with the hypothesis that PVS reflect cerebral small vessel disease; the different associations for basal ganglia and centrum semiovale PVS might indicate different underlying small vessel arteriopathies according to PVS anatomical distribution, but this requires further study.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 10, 2014 Category: Neurosurgery Authors: Hurford, R., Charidimou, A., Fox, Z., Cipolotti, L., Jager, R., Werring, D. J. Tags: Open access, Stroke, Hypertension, Memory disorders (psychiatry) Cerebrovascular disease Source Type: research

Ischemic Strokes in Pakistan: Observations from the National Acute Ischemic Stroke Database
Conclusions: Hypertension and dyslipidemia were the most common risk factors and large vessel atherosclerosis was the most common stroke etiology. Elderly patients were significantly more likely to have in-hospital complications, die during their hospital stay, and have a higher mRS score at discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2014 Category: Neurology Authors: Bhojo A. Khealani, Maria Khan, Muhammad Tariq, Abdul Malik, Alam I. Siddiqi, Safia Awan, Mohammad Wasay Tags: Original Articles Source Type: research