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Subcutaneous Heparin Therapy for Patients with Cancer-Associated Stroke
Anticoagulation therapy, particularly subcutaneous heparin therapy, is recommended for cancer-associated thrombosis. However, not starting or discontinuing anticoagulation was not rare. The aim of the present study was to examine the practical issues related to anticoagulation therapy and effects of subcutaneous heparin therapy for cancer-associated stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2018 Category: Neurology Authors: Hiroyuki Kawano, Yuko Honda, Tatsuo Amano, Haruko Okano, Rieko Suzuki, Masataka Torii, Yoshiko Unno, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Safety and Efficacy of Reperfusion Therapies for Acute Ischemic Stroke Patients With Active Malignancy
Background and Purpose: Epidemiological correlations between active malignancy (AM) and acute ischemic stroke (AIS) are well-established. However, the effect of reperfusion strategies, particularly mechanical thrombectomy (MT), has been barely investigated in patients with AIS and AM. We aim to evaluate safety and efficacy of reperfusion strategies in such patients. Materials and Methods: We performed a case-control analysis comparing patients with AM and AIS (AM group) to a group of cancer-free patients with AIS (control group).
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2019 Category: Neurology Authors: Fabrizio Sallustio, Alfredo Paolo Mascolo, Federico Marrama, Giacomo Koch, Fana Alemseged, Alessandro Davoli, Valerio Da Ros, Daniele Morosetti, Daniel Konda, Marina Diomedi Source Type: research

Hematological Abnormalities and Malnutrition Mediate Pathway between Cancer and Outcomes in Ischemic Stroke Patients
The present study aimed to examine whether variables including D-dimer, high-sensitivity C-reactive protein (hsCRP), hemoglobin, platelet count, and nutritional status mediate the pathway between cancer and ischemic stroke outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Yasufumi Gon, Daijiro Kabata, Tomohiro Kawano, Hideaki Kanki, Kenichi Todo, Tsutomu Sasaki, Ayumi Shintani, Hideki Mochizuki Source Type: research

Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients
The purpose of this study is to assess the risk factors, biomarkers of stroke, mechanism, and outcomes of cerebral infarction among cancerous diseases.
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Mohamed Abdelsalam, Mohammad Abu-Hegazy, Hend Ahmed El-Hadaad, Hanan Wahba, Hossam Egila, Ahmed Esmael Source Type: research

Use of Intravenous Thrombolysis in Acute Ischemic Stroke Management in Patients with Active Malignancies: A Topical Review
Our review aims to present existing data on the safety of Intravenous thrombolysis (IVT) use in acute ischemic stroke (AIS) patients with concomitant central nervous system or systemic malignancies, with attention to special circumstances pertaining to specific cancer subtypes to help in acute decision making, especially for neurologists and emergency medicine physicians.
Source: Journal of Stroke and Cerebrovascular Diseases - March 17, 2021 Category: Neurology Authors: Asma Akbar Ladak, Sonia Sandhu, Ahmed Itrat Source Type: research

Histopathological analysis of retrieved thrombi from patients with acute ischemic stroke with malignant tumors
Conclusions Thromboemboli of major cerebral arteries in patients with cancer were mainly composed of fibrin/platelet-rich components.
Source: Journal of NeuroInterventional Surgery - April 12, 2022 Category: Neurosurgery Authors: Kataoka, Y., Sonoda, K., Takahashi, J. C., Ishibashi-Ueda, H., Toyoda, K., Yakushiji, Y., Kusaka, H., Koga, M. Tags: Ischemic stroke Source Type: research

Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019
To describe age and sex-specific prevalence of cancer in acute ischemic stroke (AIS) hospitalizations in the United States over the last decade.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2022 Category: Neurology Authors: Fadar Oliver Otite, Sana Somani, Ehimen Aneni, Emmanuel Akano, Smit D. Patel, Nnabuchi Anikpezie, Olaoluwatomi Lamikanra, Hesham Masoud, Julius Gene Latorre, Seemant Chaturvedi, Prachi Mehndiratta Source Type: research

Effects of tumor type on outcomes in patients with large vessel occlusion stroke and cancer
Large vessel occlusions (LVO) stroke is associated with cancer. Whether this association differs among patients with LVO that undergo endovascular thrombectomy (EVT) according to cancer type remains unknown.
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2023 Category: Neurology Authors: F. Shalabi, S. Aladdin, J. Molad, Z. Itsekzon-Hayosh, T. Sacagiu, A. Honig, H. Halevi, D. Orion, J.M. Gomori, J.E. Cohen, Ronen R. Leker Source Type: research

Endovascular therapy for acute ischemic stroke in patients with active malignancy: a meta-analysis with trial sequential analysis
Conclusion Although a quarter of patients with active malignancy and AIS regained functional independence, physicians and patients should consider whether to apply EVT in patients with active malignancy.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Jhou, H.-J., Yang, L.-Y., Chen, P.-H., Lee, C.-H. Tags: Ischemic stroke Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke
Conclusions: CG-FAST scale could be an effective and simple scale for accurate identification of LVOS among AIS patients. Introduction Large vessel occlusion stroke (LVOS) often leads to severe disability and mortality. Although endovascular therapy (EVT) has been proved to be effective for LVOS patients (1–9), especially in anterior circulation, its benefit is highly time-dependent (10, 11). As hospitals with around-the-clock endovascular capability are scarce in many parts of the world and patients admitted directly to a CSC would have better outcomes than those receiving drip and ship treatment (12, 13), t...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research