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Condition: Ischemic Stroke
Nutrition: Weight Loss

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Total 80 results found since Jan 2013.

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia Basic Sciences
Conclusions— Catabolic pathways of muscle tissue are activated after stroke. Impaired feeding, sympathetic overactivation, or infection cannot fully explain this catabolic activation. Wasting of the target muscle of the disrupted innervation correlated to severity of brain injury. Our data indicate the presence of a stroke-specific sarcopenia.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Springer, J., Schust, S., Peske, K., Tschirner, A., Rex, A., Engel, O., Scherbakov, N., Meisel, A., von Haehling, S., Boschmann, M., Anker, S. D., Dirnagl, U., Doehner, W. Tags: Animal models of human disease, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Body Mass Index and Stroke Subtype in a Young Adult Stroke Population (P7.126)
CONCLUSIONS: In our group of young adult stroke patients, we found the highest BMI in the group with intracranial atherosclerosis. Although this group represented a small number of patients, this young adult population is at increased risk for future strokes. It is important to educate them on lifestyle modifications such as weight loss and exercise in addition to the treatment of hypertension, diabetes mellitus and hyperlipidemia.Disclosure: Dr. Youn has nothing to disclose. Dr. Aung has nothing to disclose. Dr. Afrasiabi has nothing to disclose. Dr. Clark has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Youn, J., Aung, T., Afrasiabi, M., Clark, J. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Diet Beverages Linked To Increased Stroke Risk & Heart Attacks
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Attack Stroke Source Type: news

Diet Drinks Linked To Increased Stroke Risk & Heart Attacks
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Attack Stroke Source Type: news

The Obesity Paradox and Survivors of Ischemic Stroke
Although obesity is a risk factor for stroke and achieving normal weight is advocated to decrease stroke risk, the risk associated with obesity and weight loss after stroke has not been well established. The aim of this study was to assess the association of obesity at the time of stroke admission and weight loss after stroke with total mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2015 Category: Neurology Authors: Peter Wohlfahrt, Francisco Lopez-Jimenez, Alena Krajcoviechova, Marie Jozifova, Otto Mayer, Jiri Vanek, Jan Filipovsky, Ernesto M. Llano, Renata Cifkova Source Type: research

Prognostic importance of weight change on short‐term functional outcome in acute ischemic stroke
ConclusionsShort‐term weight loss after stroke appears to be more common than we expected, and our results suggest that it is associated with unfavorable functional outcomes. Therefore, clinical nutrition should be considered as a component of medical treatment and weight loss should be monitored as an indicator of malnutrition.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Yerim Kim, Chi Kyung Kim, Seunguk Jung, Sang‐Bae Ko, Seung‐Hoon Lee, Byung‐Woo Yoon Tags: Research Source Type: research

Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
AbstractDespite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evok...
Source: Translational Stroke Research - December 12, 2022 Category: Neurology Source Type: research

Body Mass Index and Stroke Subtype in a Young Adult Stroke Population (I12-5D)
CONCLUSIONS: In our group of young adult stroke patients, we found the highest BMI in the group with intracranial atherosclerosis. Although this group represented a small number of patients, this young adult population is at increased risk for future strokes. It is important to educate them on lifestyle modifications such as weight loss and exercise in addition to the treatment of hypertension, diabetes mellitus and hyperlipidemia.Disclosure: Dr. Youn has nothing to disclose. Dr. Aung has nothing to disclose. Dr. Afrasiabi has nothing to disclose. Dr. Clark has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Youn, J., Aung, T., Afrasiabi, M., Clark, J. Tags: Obesity and Neurological Disorders Poster Presentations Source Type: research

Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats.
CONCLUSIONS: T2DM-MSC-Exo treatment for stroke in T2DM rats promotes neurorestorative effects and improves functional outcome. Down regulation of miR-9 expression and increasing its target ABCA1 pathway may contribute partially to T2DM-MSC-Exo treatment induced white matter remodeling and anti-inflammatory responses. PMID: 32889008 [PubMed - as supplied by publisher]
Source: Experimental Neurology - August 31, 2020 Category: Neurology Authors: Venkat P, Zacharek A, Landschoot-Ward J, Wang F, Culmone L, Chen Z, Chopp M, Chen J Tags: Exp Neurol Source Type: research

Sodium-glucose cotransporter 2 inhibitors and ischemic stroke.
CONCLUSION: Despite the multiple pleiotropic effects of SGLT-2 inhibitors, these agents do not appear to affect stroke risk. Ongoing large trials with longer follow-up will evaluate whether the pleiotropic effects of this class will translate into benefits in ischemic stroke prevention. PMID: 29412119 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice.
Abstract Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studies have assessed gut microbes as a potential source of infection following stroke. Therefore we investigated the effects of age and the role of bacterial translocation from the gut in post-stroke infection in young (8-12 weeks) and aged (18-20 months) C57Bl/6 male mice following transient middle cerebral artery occlusion (MCAO) or sham surgery. Gut permeability...
Source: Aging - April 24, 2016 Category: Biomedical Science Authors: Crapser J, Ritzel R, Verma R, Venna VR, Liu F, Chauhan A, Koellhoffer E, Patel A, Ricker A, Maas K, Graf J, McCullough LD Tags: Aging (Albany NY) Source Type: research

Epigenetic changes in the methylation patterns of KCNQ1 and WT1 after a weight loss intervention program in obese stroke patients.
The objective of this research was to investigate, in obese patients suffering a previous stroke, the effects of a nutritional program on anthropometric and biochemical variables, and on the methylation patterns of two stroke-related genes (KCNQ1: potassium channel, voltage gated KQT-like subfamily Q, member 1; and WT1: Wilms tumor 1). Twenty-two ischemic stroke patients were compared with a control group composed of eighteen obese subjects with similar age and body mass index ranges. Both groups followed a 20-week nutritional program based on an energy-restricted balanced diet with high adherence to the Mediterranean diet...
Source: Current Neurovascular Research - July 31, 2015 Category: Neurology Authors: Abete I, Gomez-Uriz AM, Mansego ML, De Arce A, Goyenechea E, Blazquez V, Martinez-Zabaleta MT, Gonzalez-Muniesa P, De Munain AL, Martinez JA, Campion J, Milagro FI Tags: Curr Neurovasc Res Source Type: research

Risk of Coronary Heart Disease and Ischemic Stroke Incidence in Gastric Cancer Survivors: A Nationwide Study in Korea.
CONCLUSIONS: CHD and ischemic stroke risk decreased after gastrectomy. The amount of weight loss and accompanying metabolic changes seemed to mediate the reduction of such risk. Reassessment of cardiovascular risk factors after gastrectomy and consideration of cardiovascular risk in the selection of treatment modality are suggested. PMID: 30043317 [PubMed - as supplied by publisher]
Source: Ann Oncol - July 24, 2018 Category: Cancer & Oncology Authors: Shin DW, Suh B, Park Y, Lim H, Suh YS, Yun JM, Cho B, Yang HK Tags: Ann Surg Oncol Source Type: research

Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research