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Quiz case: a clinical reasoning challenge in the emergency stroke setting
AbstractA right-handed woman in her 80s was admitted to the emergency department 1 h after sudden-onset global aphasia and right-sided hemiparesis. Medical history included arterial hypertension, dyslipidemia, hyperuricemia, aortic stenosis, osteoporosis, and recent pulmonary embolism. Medication consisted of apixaban, bisoprolol, hydrochlorothiazide, allopurinol, fenofibrate, and vitamin D. Vital parameters (blood pressure, heart rate, body temperature, oxygen saturation) and glycemia were all within normal range. Electrocardiogram showed a first-degree atrioventricular block. The patient was promptly transported to the e...
Source: Neurological Sciences - August 5, 2023 Category: Neurology Source Type: research

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model
In this study, we characterized the molecular m...
Source: Journal of Neuroinflammation - March 8, 2023 Category: Neurology Authors: Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai and Junwei Hao Tags: Research Source Type: research

Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape
ConclusionUsing data from a large, cross-sectional cohort program, we found that circulating 25(OH)D was related to stroke history in a reverse J-shaped manner. Given how the causal relationship between circulating 25(OH)D and history of stroke has not been established, more high-quality evidence based on the reverse J-shaped feature is needed to elucidate the link between vitamin D and stroke risk, and the effect of vitamin D supplements on stroke prevention.
Source: Frontiers in Neurology - January 5, 2023 Category: Neurology Source Type: research

Association between white matter hyperintensity volume and social functioning limitations among stroke survivors
Existing literature on white matter hyperintensity volume (WMHV) in stroke patients has rarely focused on post-stroke outcomes related to social functioning limitations, such as transportation, social interaction, food preparation, grocery shopping, and housekeeping. Using prospective data from the VITamin D and OmegA-3 TriaL (VITAL) study, we evaluated the association between WMHV and social functioning limitations among 151 ischemic stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2022 Category: Neurology Authors: Flora G. Chang, Natalia S. Rost, JoAnn E. Manson, Julie E. Buring, Pamela M. Rist Source Type: research

Vitamin D supplementation and risk of stroke: A meta-analysis of randomized controlled trials
ConclusionOur study revealed that additional vitamin D supplementation did not reduce the risk of stroke. Therefore, additional RCTs of similar design should not be encouraged to assess any association between vitamin D supplementation and reduced stroke risk.
Source: Frontiers in Neurology - August 18, 2022 Category: Neurology Source Type: research

Vitamin D level is associated with rupture of intracranial aneurysm in patients with subarachnoid hemorrhage
ConclusionVitamin D level is associated with rupture of intracranial aneurysm in patients with SAH. Patients with aneurysmal SAH have lower vitamin D levels than those with non-aneurysmal SAH.
Source: Frontiers in Neurology - August 11, 2022 Category: Neurology Source Type: research

Use of Antipsychotics is Negatively Associated with Muscle Strength in Older Adults with Sarcopenia after Stroke
The mainstay of treatment for sarcopenia is muscle mass and strength increase through exercise and nutritional intervention.1 A systematic review and meta-analysis of the effects of combined exercise and nutritional therapy for sarcopenia in older people showed that this combination may have positive effects on improving walking speed within 3 months of intervention.2 Furthermore, supplementation with whey protein, essential amino acids, and vitamin D, in conjunction with age-appropriate exercise has been reported to boost fat-free mass and strength.
Source: Journal of Stroke and Cerebrovascular Diseases - July 3, 2022 Category: Neurology Authors: Eiji Kose, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ayaka Matsumoto Source Type: research

Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT)
ConclusionLow concentrations of both vitamin K1 and 25(OH)D were associated with increased risk of stroke.
Source: Frontiers in Neurology - May 12, 2022 Category: Neurology Source Type: research

Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
Conclusions: Our results indicated that vitamin D supplementation could improve fatigue symptoms and neurological outcomes in PSF patients with vitamin D deficiency. Subject to replication in other settings, a randomized controlled trial (RCT) might be undertaken to validate the potential beneficial impact of vitamin D supplementation in post-stroke patients found to be vitamin D deficient.
Source: Frontiers in Neurology - November 5, 2021 Category: Neurology Source Type: research

Low vitamin D levels and the long ‐term functional outcome of stroke up to 5 years
ConclusionVitamin D level less than 38.4  nmol/L at admission is a potential risk biomarker for poor functional outcome at 5-year prognosis in AIS patients, which might provide new ideas for the prognostic assessment of stroke.
Source: Brain and Behavior - September 2, 2021 Category: Neurology Authors: Ya ‐Ying Zeng, Cheng‐Xiang Yuan, Meng‐Xuan Wu, Lin Cheng, Sheng‐Nan Zhou, Ping‐lang Hu, Kai‐Li Fan, Wen‐Jie Tang, Jin‐Cai He Tags: ORIGINAL RESEARCH Source Type: research

Nutritional Supplementation of Naturally Occurring Vitamin D to Improve Hemorrhagic Stroke Outcomes
Vitamin D deficiency, if left untreated, is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke. While there are various nutritional options for the natural intake of vitamin D, we hope to elucidate the potential mechanisms dietary vitamin D may play in hemorrhagic stroke pathology. This scoping review outlines findings from studies relevant to the biochemical activity of vitamin D, the impact of vitamin D deficiency on hemorrhagic stroke outcomes, and the potential benefit of nutritional vitamin D on hemorrhagic stroke outcomes. Here, we analyze the relevant factors that can lea...
Source: Frontiers in Neurology - July 30, 2021 Category: Neurology Source Type: research

Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis
Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.Eur Neurol
Source: European Neurology - July 29, 2021 Category: Neurology Source Type: research

Role of vitamin D in cerebrovascular disease
Conclusions: After reviewing current literature on the subject, we conclude that there are some data to suggest the role of vitamin D in patients with stroke but it cannot be concluded as a risk factor for stroke. Larger population-based studies are needed to confirm the causative role of vitamin D in stroke.
Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: Subhash Kaul Jayasree Manikinda Source Type: research

Millard-Gubler Syndrome Associated with Cerebellar Ataxia in a Patient with Isolated Paramedian Pontine Infarction – A Rarely Observed Combination with a Benign Prognosis: A Case Report
We report the case of a 55-year-old male patient having presented to the Yehuleshet Specialty Clinic 6 years back with sudden-onset dysarthria and appendicular ataxia of 10 days duration. He reported having right hemibody weakness and blurred vision, which have significantly improved since then. He had a history of smoking of 30 pack-years. However, he quit smoking 8 years ago. There was no history of prior stroke, transient ischemic attack, diabetes, hypertension, head trauma, or dyslipidemia. On examination, he had horizontal left gaze palsy with horizontal nystagmus suggesting left-sided 6th cranial nerve palsy. He had ...
Source: Case Reports in Neurology - April 13, 2021 Category: Neurology Source Type: research

Stroke-Induced Peripheral Immune Dysfunction in Vitamin D –Deficient Conditions: Modulation by Progesterone and Vitamin D
AbstractVitamin D deficiency (Ddef) alters morphology and outcomes after a stroke. We investigated the interaction of Ddef following post-stroke systemic inflammation and evaluated whether administration of progesterone (P) or vitamin D (D) will improve outcomes. Ddef rats underwent stroke with lipopolysaccharide (LPS)-induced systemic inflammation. Rats were randomly divided into 9 groups and treated with P, D, or vehicle for 4 days. At day 4, rats were tested on different behavioral parameters. Markers of neuronal inflammation, endoplasmic reticulum stress, oxidative stress, white matter integrity, and apoptosis were mea...
Source: Molecular Neurobiology - February 11, 2021 Category: Neurology Source Type: research

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