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Nutrition: Vitamin C
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Total 73 results found since Jan 2013.
A Bioinspired Nitrone Precursor to a Stabilized Nitroxide Radical
Free Radic Biol Med. 2021 Mar 30:S0891-5849(21)00190-8. doi: 10.1016/j.freeradbiomed.2021.03.030. Online ahead of print.ABSTRACTNitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional ni...
Source: Free Radical Biology and Medicine - April 2, 2021 Category: Biology Authors: Amanda Capistrano Pinheiro Rodrigo Boni Fazzi Larissa Cerrato Esteves Caroline Oliveira Machado Felipe Augusto D örr Ernani Pinto Yocefu Hattori Jacinto Sa Ana Maria da Costa Ferreira Erick Leite Bastos Source Type: research
Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
Hyaluronic acid (HA) is the main component of the brain extracellular matrix (ECM). During stroke, a massive breakdown of HA occurs (including perineuronal net ‐associated HA), however, the mechanism of this phenomenon remains unclear. We hypothesized that stroke up‐regulates the expression of HA metabolism‐associated enzymes and increases HA synthesis/degradation. We observed increased expression of HA‐degrading hyaluronidases and hexosaminidases, as well as HA synthases. Immunofluorescence studies revealed predominating astrocytic origin of the enzymes. Moreover, we found that inhibiting hyaluronidases with Vcpal...
Source: Journal of Neurochemistry - January 5, 2021 Category: Neuroscience Authors: Anna Katarzyna Greda,
Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research
Mitochondrial medicine therapies: rationale, evidence, and dosing guidelines
Purpose of review
Primary mitochondrial disease is a highly heterogeneous but collectively common inherited metabolic disorder, affecting at least one in 4300 individuals. Therapeutic management of mitochondrial disease typically involves empiric prescription of enzymatic cofactors, antioxidants, and amino acid and other nutrient supplements, based on biochemical reasoning, historical experience, and consensus expert opinion. As the field continues to rapidly advance, we review here the preclinical and clinical evidence, and specific dosing guidelines, for common mitochondrial medicine therapies to guide practitioners ...
Source: Current Opinion in Pediatrics - November 11, 2020 Category: Pediatrics Tags: GENETICS: Edited by Nathaniel H. Robin Source Type: research
A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications.
Abstract
Modern lifestyle, changing eating habits and reduced physical work have been known to culminate into making diabetes a global pandemic. Hyperglycemia during the course of diabetes is an important causative factor for the development of both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular (coronary artery disease, stroke and peripheral artery disease) complications. In this article, we summarize several mechanisms accountable for the development of both microvascular and macrovascular complications of diabetes. Several metabolic and cellular events are linked to the augmentation o...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Babel RA, Dandekar MP Tags: Curr Diabetes Rev Source Type: research
Vitamin C: historical perspectives and heart failure
AbstractVitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results....
Source: Heart Failure Reviews - October 8, 2020 Category: Cardiology Source Type: research
Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis.
In this study we demonstrated that parenteral administration of vitamin C significantly improved neurological deficits and reduced brain infarction and brain edema by attenuating the transient middle cerebral artery occlusion (tMCAO)-induced nitrosative stress, inflammatory responses, and the resultant disruptions of blood brain barrier and cerebral neuronal apoptosis. These results suggest that parenteral administration of vitamin C has potential as an adjuvant agent with intravenous thrombolysis or endovascular thrombectomy in acute treatment of ischemic stroke.
PMID: 32450129 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 21, 2020 Category: Biology Authors: Chang CY, Chen JY, Wu MH, Hu ML Tags: Free Radic Biol Med Source Type: research
Overlooked Virus Killer
Sales of vitamin C supplements have tripled in the last few weeks…
And the most powerful kind of vitamin C is sold out on Amazon. (More on that in a minute.)
I’m glad to see people turning to vitamin C. But the the chewable form you usually find at the drugstore won’t give you the boost you’re looking for. You see, absorption — or bioavailability — is an issue, and your body can only absorb about 500 mg of this conventional form of vitamin C before you hit saturation. And that’s nowhere near enough.
In a moment I’ll show you a better form of vitamin C… and how you can take ...
Source: Al Sears, MD Natural Remedies - May 6, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Nutrition Source Type: news
Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3.
Abstract
Cerebral small vessel disease is a common condition linked to dementia and stroke. As an age-dependent brain pathology, cerebral SVD may share molecular processes with core neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Many neurodegenerative diseases feature abnormal protein accumulation and aberrant protein folding, resulting in multimerization of specific proteins. We investigated if a small NOTCH3 N-terminal fragment (NTF) that co-registers with pathologically affected cells in the inherited SVD, CADASIL, is capable of multimerization. We also characterized endogenous small mo...
Source: Experimental Neurology - February 27, 2020 Category: Neurology Authors: Young KZ, Cartee NMP, Ivanova MI, Wang MM Tags: Exp Neurol Source Type: research
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
The objective of this study is to explore the current literature supporting the use oral multivitamins and multi/minerals (OMVMs) for cardiovascular diseases (CVD) treatment and prevention.Recent FindingsData on multivitamins, vitamin C and D, coenzyme Q, calcium, and selenium, has showed no consistent benefit for the prevention of CVD, myocardial infarction, or stroke, nor was there a benefit for all-cause mortality to support their routine supplementation. Folic acid alone and B vitamins with folic acid, B6 and B12, reduce stroke, whereas niacin and antioxidants are associated with an increased risk of all-cause mortalit...
Source: Current Cardiology Reports - February 13, 2020 Category: Cardiology Source Type: research
The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Publication date: Available online 7 November 2019Source: Food Research InternationalAuthor(s): Samad Ghaffari, Neda RoshanravanAbstractHypertension (HTN) is a worldwide epidemic in both developed and developing countries. It is one of the leading causes of major health problems such as cardiovascular disease, stroke, and heart attack. In recent years, several studies have reported associations between specific dietary ingredients and improving HTN. Nutraceuticals are natural food components with pharmacological properties. Reports suggest that functional foods and nutraceutical ingredients might support patients to obtain...
Source: Food Research International - November 8, 2019 Category: Food Science Source Type: research
Hysterectomy for men – Richard ’ s story
My wife (now 65) has had a number of minor medical problems, both mental and physical, especially after reaching 40, and when she started having panic attacks, for which no-one could provide a positive reason or cure, she finally resorted to drugs, such as sertraline, much against her natural inclination.
A known side-effect of this is increased weight. My wife has never been really overweight, but, in common with so many women, is very sensitive about the subject (perhaps more so because I CANNOT put on weight!), so when she started to increase in girth, I was reluctant to mention it, for fear of upsetting her even more...
Source: The Hysterectomy Association - August 3, 2019 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health hysterectomy stories ovarian cyst Source Type: news
