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Nutrition: Vitamin C

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Total 73 results found since Jan 2013.

High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes
AbstractVitamin C has recently been identified as an epigenetic regulator by activating ten-eleven translocases (TETs), enzymes involved in generating DNA hydroxymethylcytosine (5hmC). Currently, we investigated whether high-dose vitamin C promotes neuroprotection through epigenetic modulation of 5hmC, if there are sex-specific differences in outcome, and the therapeutic potential of vitamin C in stroke-related comorbidities in adult mice. Post-stroke treatment with ascorbate (reduced form), but not dehydroascorbate (oxidized form), increased TET3 activity and 5hmC levels and reduced infarct following focal ischemia. Hydro...
Source: Translational Stroke Research - March 20, 2022 Category: Neurology Source Type: research

Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
Hyaluronic acid (HA) is the main component of the brain extracellular matrix (ECM). During stroke, a massive breakdown of HA occurs (including perineuronal net ‐associated HA), however, the mechanism of this phenomenon remains unclear. We hypothesized that stroke up‐regulates the expression of HA metabolism‐associated enzymes and increases HA synthesis/degradation. We observed increased expression of HA‐degrading hyaluronidases and hexosaminidases, as well as HA synthases. Immunofluorescence studies revealed predominating astrocytic origin of the enzymes. Moreover, we found that inhibiting hyaluronidases with Vcpal...
Source: Journal of Neurochemistry - January 5, 2021 Category: Neuroscience Authors: Anna Katarzyna Greda, Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research

Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model
This article is protected by copyright. All rights reserved.
Source: Basic and Clinical Pharmacology and Toxicology - April 21, 2015 Category: Drugs & Pharmacology Authors: Mohammad Allahtavakoli, Fatemeh Amin, Ali Esmaeeli Nadimi, Ali Shamsizadeh, Mohammad Kazemi Arababadi, Derek Kennedy Tags: Original Article Source Type: research

Effects of vitamin C stimulation on rehabilitation of dysphagia after stroke: a randomized trial
CONCLUSION: Vitamin C acid stimulation significantly improves rehabilitation of stroke patients with dysphagia, and ameliorates the nutritional status and immune function of patients.PMID:35362717 | DOI:10.23736/S1973-9087.22.07337-3
Source: European Journal of Physical and Rehabilitation Medicine - April 1, 2022 Category: Rehabilitation Authors: Jiongmei Wang E Chang Yujuan Jiang Source Type: research

Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
AbstractPerineuronal nets (PNNs) are presumed to limit plasticity in adult animals. Ischemic stroke results in the massive breakdown of PNNs resulting in rejuvenating states of neuronal plasticity, but the mechanisms of this phenomenon are largely unknown. As hyaluronic acid (HA) is the structural backbone of PNNs, we hypothesized that these changes are a consequence of altered expression of HA metabolism enzymes. Additionally, we investigated whether early hyaluronidase inhibition interferes with poststroke PNN reduction and behavioural recovery.We investigated the mRNA/protein expression of these enzymes in the perilesio...
Source: Journal of Neurochemistry - December 20, 2020 Category: Neuroscience Authors: Anna Katarzyna Greda, Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research

Predictive role of modifiable factors in stroke: an umbrella review
Discussion Diet with rich macronutrients and micronutrients, healthy dietary patterns and favourable physical, emotional health and environmental management should be promoted to decrease the burden of stroke. PROSPERO registration number CRD42021249921.
Source: BMJ Open - June 16, 2022 Category: General Medicine Authors: Wang, X., Liang, M., Zeng, F., Wang, Y., Yang, Y., Nie, F., Shang, M., Ta, N., Wen, L., Ou, L., Yang, Z., Liu, W. Tags: Open access, Neurology Source Type: research

Observation of Clinical Efficacy of Anisodamine and Chlorpromazine in the Treatment of Intractable Hiccup after Stroke
CONCLUSION: The combination of 2D K-L divergence and MPSO algorithm could improve the accuracy of multilayer image segmentation and CT imaging. Acupoint injection of anisodamine combined with chlorpromazine had better efficacy than the injection of anisodamine alone for the treatment of intractable hiccups after stroke, with high safety and clinical promotion value.PMID:35915796 | PMC:PMC9338746 | DOI:10.1155/2022/6563193
Source: Biomed Res - August 2, 2022 Category: Research Authors: Jing Wang Qinghua Zhu Shuyan Zhang Lisha Wen Li Wang Source Type: research