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Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research

The proteomics analysis of the effects of Zhishi Rhubarb soup on ischaemic stroke
Stroke has always been a major threat worldwide but is most severe in China, with 2.5 million new stroke cases each year and 7.5 million stroke survivors, placing a heavy burden on the social and national heal...
Source: Proteome Science - November 10, 2021 Category: Bioinformatics Authors: Jing-Hua Zhang, Yue-Jia Shao, Zhen Hui, Su-Lei Wang, Chi Huang and Yang Zhao Tags: Research Source Type: research

Rhubarb anthraquinone glycosides against cerebral ischaemia-reperfusion injury in rats by regulating brain-gut neurotransmitters.
In this study, an HPLC-FLD method was established to measure brain-gut neurotransmitters of rats with cerebral ischaemia-reperfusion injury (CIRI), to explore whether the mechanism of RAGs against CIRI is related to the microbiome-gut-brain axis. A SHIMADZU ODS-3 C18 column was employed for chromatographic separation, and 5-hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA), glutamic acid (Glu), aspartic acid (Asp), and γ-aminobutyric acid (GABA) were determined simultaneously. The results showed that there is a excellent linear relationship (R2 ≥ 0.9990) and a separation degree in the HPLC-FLD method. An...
Source: Biomedical Chromatography : BMC - December 29, 2020 Category: Biomedical Science Authors: Guo Y, Li Q, Yu X, Liang Y Tags: Biomed Chromatogr Source Type: research

Protective mechanism of rhubarb anthraquinone glycosides in rats with cerebral ischaemia –reperfusion injury: interactions between medicine and intestinal flora
Anthraquinone glycosides extracted from rhubarb have been proven to have significant therapeutic effects on ischaemic stroke. It is well known that anthraquinone glycosides are not easily absorb. Thus, how can...
Source: Chinese Medicine - June 5, 2020 Category: Complementary Medicine Authors: Qiuying Li, Ying Guo, Xiahui Yu, Wenhong Liu and Liping Zhou Tags: Research Source Type: research

Herbal Compatibility of Ginseng and Rhubarb Exerts Synergistic Neuroprotection in Cerebral Ischemia/Reperfusion Injury of Rats
ConclusionThe herbal compatibility of Ginseng and Rhubarb synergistically exerts neuroprotective function during acute cerebral I/R injury, mainly through reducing the expression of Cx43 and AQP4.
Source: Frontiers in Physiology - September 12, 2019 Category: Physiology Source Type: research

Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases.
Authors: Li X, Chu S, Liu Y, Chen N Abstract Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer's disease, depression, and others. We review the experimental studies on thes...
Source: Evidence-based Complementary and Alternative Medicine - June 23, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Adjuvant rhubarb alleviates organs dysfunction and inhibits inflammation in heat stroke.
In conclusion, rhubarb intake provided a significant benefit for patients with heat stroke by inhibiting systemic inflammation and mitigating liver and kidney injury. PMID: 30116399 [PubMed]
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

The pharmacokinetic screening of multiple components of the Nao Mai Tong formula in rat plasma by liquid chromatography tandem mass spectrometry combined with pattern recognition method and its application to comparative pharmacokinetics
Publication date: 30 November 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 131 Author(s): Chunwei Wu, Lu Zhao, Yueying Rong, Guoxue Zhu, Shengwang Liang, Shumei Wang The Nao Mai Tong formula (NMT) is composed of Rhubarb, Ginseng, Ligusticum wallichii and Pueraria in a ratio of 3:3:2:2 (w/w) and is a well-known traditional Chinese prescription that has been clinically employed for treating ischemia cerebrovascular disease. The goal of this study was to investigate the pharmacokinetics of multiple components (chryohol-8-O-β-D-glucoyroide, physcion-8-O-β-D-glucopyranoside, aloe-emodin, rhein, emodi...
Source: Journal of Pharmaceutical and Biomedical Analysis - September 12, 2016 Category: Drugs & Pharmacology Source Type: research

Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia.
In conclusion, these findings demonstrated a possible efficacy of ACRRR that have potential neuroprotective effect for experimental ischemic stroke. However, these apparently positive findings should be interpreted with caution because of the methodological flaws. PMID: 26495006 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - October 24, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Rhubarb root and rhizome-based Chinese herbal prescriptions for acute ischemic stroke: A systematic review and meta-analysis.
CONCLUSIONS: Despite the apparently positive findings, it is premature to recommend the routine use of RRR-based prescriptions for acute ischemic stroke because methodological flaws undermine the strength of our findings. However, this work identifies an area, which is worthy of improvement and development for further research. Larger sample-sizes and rigorously designed RCTs are required in the future. PMID: 25453529 [PubMed - as supplied by publisher]
Source: Complementary Therapies in Medicine - December 1, 2014 Category: Complementary Medicine Authors: Lu L, Li HQ, Fu DL, Zheng GQ, Fan JP Tags: Complement Ther Med Source Type: research

8 Whole Grains You're Probably Not Eating
By Cynthia Sass, MPH, RD You've probably had oatmeal for breakfast, and if you haven't yet tried quinoa I bet you've heard of it, or have seen it on a menu or social media recipe (it's all over Pinterest!). But there are many other whole grains you may not be familiar with, and incorporating them into your food repertoire is well worth the learning curve. Whole grains are white hot among chefs and nutritionists. They're versatile, satisfying and in addition to providing slow-burning starch (think sustained energy!), vitamins, minerals and antioxidants, whole grains are health protective. Their consumption is tied to a lo...
Source: Healthy Living - The Huffington Post - November 22, 2014 Category: Consumer Health News Source Type: news

Emodin accentuates atrial natriuretic peptide secretion in cardiac atria.
Abstract Emodin, an active anthraquinone constituent isolated from the rhubarb, a traditional Chinese herbal medicine which is widely used in clinical treatment, has cardiovascular protective properties. However, it remains unclear whether the cardiovascular protective actions of emodin are related to an activation of cardiac natriuretic hormone secretion. The purpose of the present study was to explore the effect of emodin on the secretion of ANP, a member of the family of cardiac natriuretic hormones, and its mechanisms involved. Experiments were performed in isolated perfused beating rabbit atria allowing measu...
Source: European Journal of Pharmacology - April 18, 2014 Category: Drugs & Pharmacology Authors: Hai Zhou G, Zhang F, Nong Wang X, Jeong Kwon O, Gill Kang D, Sub Lee H, Nan Jin S, Woo Cho K, Fu Wen J Tags: Eur J Pharmacol Source Type: research