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Total 296 results found since Jan 2013.
Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1
Exp Brain Res. 2022 Dec 23. doi: 10.1007/s00221-022-06519-z. Online ahead of print.ABSTRACTWe aim to research the molecular mechanism of lncRNA NEAT1 in the activation of astrocytes in a cerebral ischemia-reperfusion injury model. Mouse model of cerebral ischemia-reperfusion injury was constructed, and shNEAT1 was transfected. The infarct area, brain water content, and neurological deficiency were detected. Immunofluorescence detection and fluorescence in situ hybridization (FISH) assay were processed to detect glial fibrillary acidic protein (GFAP) expression. Astrocyte cells were cultured for oxygen-glucose deprivation/r...
Source: Brain Research - December 23, 2022 Category: Neurology Authors: Haijian Zheng Gai Zhang Guanglan Liu Ling Wang Source Type: research
Channa striatus in inflammatory conditions: A systematic review
Channa striatus (CS), or snakehead murrel, is an obligate air-breathing freshwater fish. Besides its wound healing properties, CS has also been reported to exhibit anti-inflammatory effects in multiple studies. While there are anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), their long-term use is associated with an increased risk of peptic ulcers, acute renal failure, stroke, and myocardial infarction. Thus, it is essential to look at natural methods such as CS extract. While there is an abundant number of investigative studies on the inflammatory properties of CS, the quality of these ...
Source: Frontiers in Pharmacology - December 5, 2022 Category: Drugs & Pharmacology Source Type: research
Stroke, Dietary Fish, Milk, and Sugar Consumption Correlates of Alzheimer's and Parkinson's Dementia
To investigate the potentially confounding factors in the relationship between daily sugar intake versus Alzheimer& Parkinson's related death rates, including milk, meat, fish and alcohol consumption; obesity, stroke, hypertension, cancer and diabetes rates; tobacco use; and gross domestic purchasing power parity in different countries.
Source: Archives of Physical Medicine and Rehabilitation - December 1, 2022 Category: Rehabilitation Authors: Kurt Gold, Jacob Galloway, Justin Schwartz, Jonathan Huefner, Elizabeth Call, Taoyuan Beninato, Gabriela Garaycochea, Ronald Bulbulian Tags: Research Poster 2184247 Source Type: research
Use of Fish Oil and Mortality of Patients with Cardiometabolic Multimorbidity: A Prospective Study of UK Biobank
This study aimed to estimate the association between use of fish oil and mortality among patients with CMM. Methods and Results: In this prospective study based on UK Biobank, participants with ≥2 of cardiometabolic diseases (CMDs, including coronary heart disease [CHD], diabetes, hypertension, and stroke in this study) at recruitment were included.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 28, 2022 Category: Nutrition Authors: Tianqi Ma, Lingfang He, Yi Luo, Guogang Zhang, Xunjie Cheng, Yongping Bai Source Type: research
Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish
Biomed Pharmacother. 2022 Sep 23;155:113744. doi: 10.1016/j.biopha.2022.113744. Online ahead of print.ABSTRACTIschemic stroke is a leading cause of death worldwide, and it remains an urgent task to develop novel and alternative therapeutic strategies for the disease. We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting functional recovery in ischemic stroke mice. However, the active substances and pharmacological mechanism of GHI is still elusive. Aiming to identify the active anti-stroke components in GHI, here we conducted a multi-phenotypic s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 26, 2022 Category: Drugs & Pharmacology Authors: Yule Wang Huimin Wu Hongda Sheng Yingchao Wang Xuecai Li Yi Wang Lu Zhao Source Type: research
How to Lower Your Cholesterol Naturally
In the years following World War II, physicians in the U.S. and Europe noticed a surprising phenomenon: rates of heart attack and stroke fell dramatically in many places. Autopsies from this period also revealed reduced rates of atherosclerosis, which is a buildup of fatty arterial plaques that causes cardiovascular disease.
At first, experts were perplexed. But as time passed, many concluded that wartime food deprivations and the forced shifts in people’s diets—namely, big reductions in the consumption of red meat and other animal products—contributed to the heart-health improvements. Later work, particu...
Source: TIME: Health - August 30, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news
A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Biomaterials. 2022 Aug 15:121729. doi: 10.1016/j.biomaterials.2022.121729. Online ahead of print.ABSTRACTBrain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow for simultaneous morphological and functional phenotypic data capture in real time during AVM disease progress...
Source: Biomaterials - August 23, 2022 Category: Materials Science Authors: Kayla Soon Mengyuan Li Ruilin Wu Angela Zhou Negar Khosraviani Williamson D Turner Joshua D Wythe Jason E Fish Sara S Nunes Source Type: research
Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research
People With Diabetes Are More Vulnerable to Heart Disease. How to Reduce the Risk
If you’ve been diagnosed with diabetes, know that you’ve got plenty of company. The American Diabetes Association (ADA) reports that in 2019, the most recent year for which data is available, 37.3 million adults in the U.S.—about 11.3% of the population—had the chronic condition, and that number continues to grow.
Type 1 diabetes develops when the body isn’t able to produce insulin, and Type 2 occurs when the body doesn’t use insulin correctly. Type 2 is the most common form of diabetes, and when it’s uncontrolled, a person’s blood sugar can jump to dangerous levels that requ...
Source: TIME: Health - July 20, 2022 Category: Consumer Health News Authors: Elaine K. Howley Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news
Fatal adverse events of rivaroxaban combined with aspirin: an analysis using data from VigiBase
ConclusionsFatal AEs related to rivaroxaban combined with aspirin, including bleeding and ischemic events, have been reported mostly in the elderly, and sometimes involved medication errors. The fatal AEs mainly manifested as serious bleeding, and most of them occurred in patients with concurrent multiple risk factors. Monitoring coagulation during rivaroxaban treatment is recommended in very high-risk ASCVD populations, and attention should be paid to prevention of medication errors.
Source: European Journal of Clinical Pharmacology - July 1, 2022 Category: Drugs & Pharmacology Source Type: research
