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Condition: Ischemic Stroke
Nutrition: Diets
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Total 663 results found since Jan 2013.
Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury.
The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent and administered MICA to rats mainly via dietary intake. Upon completion of 4 week's MICA treatment, rats underwent 1h transient ischemia and 24h reperfusion followed by tissue collection. Our results show that MICA protected the brain against ischemic stroke injury as the infarction volume of the brain from t...
Source: Free Radical Biology and Medicine - October 7, 2017 Category: Biology Authors: Wu J, Li R, Li W, Ren M, Thangthaeng N, Sumien N, Liu R, Yang S, Simpkins JW, Forster MJ, Yan LJ Tags: Free Radic Biol Med Source Type: research
Diet and primary prevention of stroke: Systematic review and dietary recommendations by the ad hoc Working Group of the Italian Society of Human Nutrition
Conclusions The present literature review and dietary recommendations provide healthcare professionals and all interested readers with a useful overview for the reduction of the risk of total, ischemic and haemorrhagic stroke through dietary modifications.
Source: Nutrition, Metabolism and Cardiovascular Diseases - March 11, 2018 Category: Nutrition Source Type: research
FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation
ConclusionsThis study shows a significant correlation between FDG atrial uptake and AF. While inconsistent, this pattern seems to be associated with an increased prevalence of cardioembolic stroke.
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 27, 2019 Category: Nuclear Medicine Source Type: research
Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells
AbstractWe recently reported that diabetes negates the cerebrovascular protection typically seen in adult female rats resulting in cognitive impairment, which is worsened by increased parenchymal bleeding and edema after ischemic stroke. Although women experience more severe diabetes and suffer from a higher rate of diabetic complications, including stroke and cognitive impairment, underlying mechanisms contributing to sex differences are limited. Emerging evidence suggests interleukin (IL)-17 contributes to cerebrovascular pathologies: (1) high salt diet-mediated expansion of IL-17-producing T cells (Th17) in the gut micr...
Source: NeuroMolecular Medicine - June 12, 2019 Category: Neurology Source Type: research
Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke.
Abstract
Stroke leads to devastating outcomes including impairments of sensorimotor and cognitive function that may be long lasting. New intervention strategies are needed to overcome the long-lasting effects of ischemic injury. Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred chemical preconditioning and neuroprotection against stroke. The purpose of the current study was to determine whether the preconditioning can lead to functional improvements after stroke (done by transient middle cerebral artery occlusion). After 4 weeks of MICA feeding, half the rats underw...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Sumien N, Huang R, Chen Z, Vann PH, Wong JM, Li W, Yang S, Forster M, Yan LJ Tags: Behav Brain Res Source Type: research
IJERPH, Vol. 17, Pages 8788: Usability and Acceptability of a Novel Secondary Prevention Initiative Targeting Physical Activity for Individuals after a Transient Ischaemic Attack or ”Minor” Stroke: A Qualitative Study
Donnelly
Behavioural interventions that address cardiovascular risk factors such as physical inactivity and hypertension help reduce recurrence risk following a transient ischaemic attack (TIA) or ”minor” stroke, but an optimal approach for providing secondary prevention is unclear. After developing an initial draft of an innovative manual for patients, aiming to promote secondary prevention following TIA or minor stroke, we aimed to explore views about its usability and acceptability amongst relevant stakeholders. We held three focus group discussions with 18 participants (people who had...
Source: International Journal of Environmental Research and Public Health - November 26, 2020 Category: Environmental Health Authors: Heron O ’Connor Kee Mant Cupples Donnelly Tags: Article Source Type: research
Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes
Conclusion: An HT-enriched diet significantly increased the number of Iba-1+ microglia/macrophages in the post-ischemic area, inducing higher expression of anti-inflammatory markers while no clear-cut effect was observed. Also, HT did not affect recovery of the cerebrovascular parameters, including ADC and CBF.Altogether, our data indicated that a prolonged dietary intervention with HT, as a single component of the Mediterranean diet, induces molecular changes that may improve stroke outcomes. Therefore, we support the use of the Mediterranean diet as a multicomponent therapy approach after stroke.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cristina Barca, Maximilian Wiesmann, Jes ú s Calahorra, Lydia Wachsmuth, Christian D ö ring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Á ngeles Peinado, Eva Siles, Cornelius Faber, Michael Sch ä fers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Tags: Research Paper Source Type: research
The natural (poly)phenols as modulators of microglia polarization via TLR4/NF- κB pathway exert anti-inflammatory activity in ischemic stroke
Eur J Pharmacol. 2021 Dec 1:174660. doi: 10.1016/j.ejphar.2021.174660. Online ahead of print.ABSTRACTIncreasing evidences suggest that inflammation plays a key role in the pathogenesis of stroke, a devastating disease second only to cardiac ischemia as a cause of death worldwide. Microglia are the first non-neuronal cells on the scene during the innate immune response to acute ischemic stroke. Microglia respond to acute brain injury by activating and developing classic M1-like (pro-inflammatory) or alternative M2-like (anti-inflammatory) phenotypes. M1 microglia produce pro-inflammatory cytokines to exacerbate neural death...
Source: European Journal of Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Ruoqi Li Yuan Zhou Shanshan Zhang Jieying Li Yingyi Zheng Xiang Fan Source Type: research
Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study
CONCLUSION: Drinking water with a high concentration of calcium and magnesium, particularly magnesium, may lower the risk of stroke in postmenopausal women.PMID:35816459 | DOI:10.1093/ajcn/nqac186
Source: The American Journal of Clinical Nutrition - July 11, 2022 Category: Nutrition Authors: Emilie Helte Melle S äve-Söderbergh Susanna C Larsson Agneta Åkesson Source Type: research
Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke.
CONCLUSION: This study reveals potentially beneficial effects of a diet containing elevated amounts of anti-inflammatory nutrients on the recovery from ischemic brain damage. Therefore, dietary intervention can be considered as an adjuvant therapy for recovery from this brain pathology.
PMID: 29804326 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Kurtys E, Casteels C, Real CC, Eisel ULM, Verkuyl JM, Broersen LM, Klein HC, Dierckx RAJO, Doorduin J, de Vries EFJ Tags: CNS Neurosci Ther Source Type: research
Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
CONCLUSIONS: The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels.
PMID: 29976769 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 5, 2018 Category: Cardiology Authors: Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U Tags: Arterioscler Thromb Vasc Biol Source Type: research
