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Total 498 results found since Jan 2013.
Evaluation of anti-inflammatory diphenyldihaloketone EF24 in transient ischemic stroke model
CONCLUSIONS: EF24 controls infarct growth and suppresses tissue inflammation in ischemic stroke, which can be monitored by 18F-FGA uptake.PMID:35254869 | DOI:10.1080/02699052.2022.2034959
Source: Brain Injury - March 7, 2022 Category: Neurology Authors: Alexander Mdzinarishvili Hailey Houson Andria Hedrick Vibhudutta Awasthi Source Type: research
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1 α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury
In conclusion, our results suggested that ISO combined with NT-1 could promote angiogenesis, recover long-term neurobehavioral function, and attenuate cerebral ischemia injury by activating the HIF-1α-Netrin-1-UNC5B/VEGF cascade.PMID:35247371 | DOI:10.1016/j.expneurol.2022.114028
Source: Experimental Neurology - March 5, 2022 Category: Neurology Authors: Nian Li Xu Zhang Jingwen Zhai Jiangwen Yin Ketao Ma Ruixue Wang Xinlei Qin Yan Li Xiwei Dong Sheng Wang Source Type: research
AKT/GSK-3 β signaling is altered through downregulation of mTOR during cerebral Ischemia/Reperfusion injury
CONCLUSION: Our findings provide new insight into the cellular responses to ischemia/reperfusion brain injury and will help develop new treatments targeting the AKT signaling pathway for the treatment of ischemic stroke.PMID:35235160 | DOI:10.1007/s11033-022-07247-x
Source: Molecular Biology Reports - March 2, 2022 Category: Molecular Biology Authors: Shengwei Peng Jin-Hua Gu Chun-Ling Dai Khalid Iqbal Fei Liu Cheng-Xin Gong Source Type: research
Folium < em > Ginkgo < /em > extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
CONCLUSIONS: Xingxiong injection prevents cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome. These findings provide experimental evidence for clinical use of drugs in the treatment of ischaemic stroke.PMID:35060427 | PMC:PMC8786246 | DOI:10.1080/13880209.2021.2014895
Source: Pharmaceutical Biology - January 21, 2022 Category: Drugs & Pharmacology Authors: Ting Zhu Bin-Yu Fang Xiang-Bao Meng Shu-Xia Zhang Hong Wang Ge Gao Fei Liu Yu Wu Jin Hu Gui-Bo Sun Xiao-Bo Sun Source Type: research
Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach
CONCLUSIONS: This study showed that DSS can treat IS through multiple targets and routes and provided new insights to explore the mechanisms of DSS against IS.PMID:35035503 | PMC:PMC8754614 | DOI:10.1155/2022/3747285
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Sijie Li Yong Yang Wei Zhang Haiyan Li Wantong Yu Chen Gao Jiali Xu Wenbo Zhao Changhong Ren Source Type: research
Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation
Neurochem Res. 2022 Jan 7. doi: 10.1007/s11064-021-03492-x. Online ahead of print.ABSTRACTIschemic stroke (IS) is a cerebrovascular disease with high morbidity, recurrence, and mortality. The purpose of the present study was to investigate the role and mechanism of human serum exosomes on angiogenesis after IS. The middle cerebral artery occlusion (MCAO) in vivo model and oxygen-glucose deprivation (OGD) in vitro model were established. Human serum exosomes from healthy samples (NC-exo) and IS samples (IS-exo) were injected into MCAO mice. Neurobehavioral tests were performed to assess the extent of neurological deficits. ...
Source: Neurochemical Research - January 7, 2022 Category: Neuroscience Authors: Chuan Xu Hailong Yu Beilei Chen Yuan Ma Penghua Lv Source Type: research
Preconditioning With Intermittent Hypobaric Hypoxia Attenuates Stroke Damage and Modulates Endocytosis in Residual Neurons
Conclusions: Intermittent hypobaric hypoxia preconditioning exerts a neuroprotective effect in a rat stroke model. Persistent hypobaric hypoxia stimulation exhibited no significant neuroprotective effect. Intermittent hypoxic preconditioning for 6 h/day for 10 days upregulates key proteins in clathrin-dependent endocytosis of neurons in the cortex.
Source: Frontiers in Neurology - December 15, 2021 Category: Neurology Source Type: research
