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Condition: Heart Attack
Nutrition: Calcium

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Total 275 results found since Jan 2013.

A Cost Utility Analysis of Amlodipine Compared with Angiotensin II Receptor Blockers in Preventing Stroke and Myocardial Infarction Among Hypertension Patients in the Philippines
Hypertension represents a major health problem, affecting more than 21% of adults in the Philippines. Amlodipine, a calcium channel blocker, is considered to have better tolerance and effectiveness than other classes of antihypertensive treatments. Limited studies have examined the cost-effectiveness of Amlodipine in the Philippines. The purpose of this study was to compare the costs and effectiveness associated with Amlodipine and Angiotensin II Receptor Blockers (Valsartan) in preventing stroke and myocardial infarction (MI) among Filipino hypertension patients.
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: G Encelan-Brizuela, K.Y. Lin, L. Liu Source Type: research

A Cost-Utility Analysis of Calcium Channel Blockers (Ccbs) Compared with Angiotensin II Receptor Blockers (Arbs) In Preventing Stroke And Myocardial Infarction Among Hypertension Patients In The Taiwan
Hypertension is a major risk factor for stroke and myocardial infarction (MI), which imposes a substantial burden on patients, caregivers, and society. Despite the high financial burden, limited studies have examined the cost-effectiveness of hypertension treatments in Taiwan. This cost utility analysis was conducted to determine the costs and quality-adjusted life years (QALYs) associated with amlodipine (CCB) and valsartan (ARB) in preventing stroke and MI among Taiwanese hypertension patients.
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: C.H. Fang, K.Y. Lin, Y.C. Huang, L. Liu Source Type: research

Bedtime Hypertension Chronotherapy: Concepts and Patient Outcomes.
Abstract Recent findings indicate cardiovascular disease (CVD) risk is best predicted by asleep systolic blood pressure (SBP), and lowering it by scheduling ≥1 conventional long-acting hypertension medications, alone or in combination, at bedtime significantly lessens vascular-associated risks. Some 20 years ago, four controlled-onset extended-release drug-delivery systems incorporating a calcium channel blocker or β-blocker, with the treatment goal specifically being attenuation of morning rather than asleep BP, were conceived as one type of bedtime hypertension chronotherapy. However, the CONVINCE outcomes tr...
Source: Current Pharmaceutical Design - October 24, 2014 Category: Drugs & Pharmacology Authors: Smolensky MH, Hermida RC, Ayala DE, Portaluppi F Tags: Curr Pharm Des Source Type: research

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning
Publication date: 2014 Source:Redox Biology, Volume 2 Author(s): Theodore Kalogeris , Yimin Bao , Ronald J. Korthuis Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct. Being highly metabolic organs, the heart and brain are particularly vulnerable to the deleterious effects of ischemia/reperfusion (I/R). While the pathogenetic mechanisms contributing to I/R-induced tissue injury and infarction are multifactorial, the relative importance of eac...
Source: Redox Biology - October 12, 2014 Category: Biology Source Type: research

Platelet 12-LOX is essential for Fc{gamma}RIIa-mediated platelet activation
In this study, we show for the first time that platelet 12(S)-lipoxygenase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an essential component of FcRIIa-mediated thrombosis. Pharmacologic inhibition of 12-LOX in human platelets resulted in significant attenuation of FcRIIa-mediated aggregation. Platelet 12-LOX was shown to be essential for FcRIIa-induced phospholipase C2 activity leading to activation of calcium mobilization, Rap1 and protein kinase C activation, and subsequent activation of the integrin αIIbβ3. Additionally, platelets from transgenic mice expressing human FcR...
Source: Blood - October 2, 2014 Category: Hematology Authors: Yeung, J., Tourdot, B. E., Fernandez-Perez, P., Vesci, J., Ren, J., Smyrniotis, C. J., Luci, D. K., Jadhav, A., Simeonov, A., Maloney, D. J., Holman, T. R., McKenzie, S. E., Holinstat, M. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability
Purpose of reviewAtherosclerotic plaque rupture and subsequent acute events, such as myocardial infarction and stroke, contribute to the majority of cardiovascular-related deaths. Calcification has emerged as a significant predictor of cardiovascular morbidity and mortality, challenging previously held notions that calcifications stabilize atherosclerotic plaques. In this review, we address this discrepancy through recent findings that not all calcifications are equivalent in determining plaque stability. Recent findingsThe risk associated with calcification is inversely associated with calcification density. As opposed to...
Source: Current Opinion in Lipidology - October 1, 2014 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Andrew Newby and Yury Miller Source Type: research

Elevated Parathyroid Hormone, But Not Vitamin D Deficiency, Is Associated With Increased Risk of Heart Failure in Older Men With and Without Cardiovascular Disease Original Articles
Conclusions— Elevated PTH, but not 25-hydroxyvitamin D or other markers of mineral metabolism, is associated with increased risk of HF in both older men with and without myocardial infarction/stroke. This increased risk was not explained by its association with known risk factors for HF. Further studies are now needed to elucidate the mechanisms underlying this association.
Source: Circulation: Heart Failure - September 16, 2014 Category: Cardiology Authors: Wannamethee, S. G., Welsh, P., Papacosta, O., Lennon, L., Whincup, P. H., Sattar, N. Tags: Congestive, Epidemiology Original Articles Source Type: research

Calcium Supplements Increase Risk of Myocardial Infarction
Abstract The cardiovascular safety of calcium supplements has been revisited with a further meta‐analysis,(1) which concludes that calcium supplementation does not increase coronary heart disease in women, without providing data for men. Their conclusion is at odds with that of our meta‐analyses, which reported that calcium increased the risk of myocardial infarction (MI) and possibly stroke in men and women together.(2,3)There are important differences between approaches to the meta‐analyses. In the current paper and previously, the authors suggest that including men and self‐reported events may have explained the...
Source: Journal of Bone and Mineral Research - September 11, 2014 Category: Orthopaedics Authors: Mark J Bolland, Andrew Grey, Alison Avenell, Ian R Reid Tags: Letter to the Editor Source Type: research

The Case Files: When a Spade is Not a Spade
Turrin, Danielle DO; Sattler, Steven DO; Amodeo, Dana DO A 25-year-old Hispanic man presented to the emergency department with a complaint of three days of left-sided precordial chest pain. He described the pain as a constant 6/10 with pressure-like discomfort radiating to his left arm and the left side of his neck. He also experienced nausea, but denied any provocative or palliative factors. He said he had not experienced anything similar to this before. He had no family history of heart disease, acute myocardial infarction, or sudden cardiac death. He admitted to a 1.5 pack-per-day smoking history and social alcohol use,...
Source: The Case Files - August 26, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Cardiovascular endocrinology: Controversy—cardiovascular effects of calcium supplementation
Nature Reviews Endocrinology 10, 641 (2014). doi:10.1038/nrendo.2014.146 Author: Ian R. Reid Of late, clinical trial data, meta-analyses and observational studies have caused concern that the use of calcium supplements might increase the risk of myocardial infarction and stroke. A new meta-analysis suggests that there is no problem with calcium supplements, but as the analysis includes controversial data omitted from previous analyses, the debate will continue.
Source: Nature Reviews Endocrinology - August 19, 2014 Category: Endocrinology Authors: Ian R. Reid Tags: News and Views Source Type: research

Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis.
CONCLUSION: Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke. PMID: 25057156 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - July 23, 2014 Category: Nutrition Authors: Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M, for the RECORD Trial Group Tags: Am J Clin Nutr Source Type: research

Calcium Channel Blocker Compared With Angiotensin Receptor Blocker for Patients With Hypertension: A Meta‐Analysis of Randomized Controlled Trials
To explore the clinical effects of a calcium channel blocker compared with an angiotensin II receptor blocker in hypertensive patients, the authors collected data from randomized controlled trials. The pooled outcomes were all‐cause mortality, stroke, myocardial infarction, and heart failure. Eight head‐to‐head trials enrolling 25,084 patients were included. There was no significant mortality difference in the two arms (relative risk, 0.99; 95% confidence interval, 0.91–1.07). However, calcium channel blockers were more effective in reducing stroke (relative risk, 0.87; 95% confidence interval, 0.76–0.99) and myo...
Source: The Journal of Clinical Hypertension - July 1, 2014 Category: Cardiology Authors: Ling Wu, Song‐Bai Deng, Qiang She Tags: Review Paper Source Type: research

Calcium supplements associated with increased risk of cardiovascular death in men but not women
Commentary on: Xiao Q, Murphy RA, Houston DK, et al.. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med 2013;173:639–46 Implications for practice and research Calcium supplements increase cardiovascular risk. The role of calcium supplements in the management of osteoporosis should be reconsidered. Context In 2008, a randomised controlled trial (RCT) suggested that calcium supplements might increase the risk of cardiovascular events.1 Subsequent meta-analyses of RCTs examining calcium monotherapy and calcium and v...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: Bolland, M. J., Grey, A. Tags: Primary health care, Drugs: cardiovascular system, Stroke, Diet, Ischaemic heart disease, Osteoporosis Source Type: research

P-119 * different measures to prevent atrial fibrillation in patients undergoing pulmonary resection for lung cancer: evidence from a comprehensive network meta-analysis of randomized and observational studies
Conclusions: Beta-blockers and flecainide are effective in reducing the incidence of postoperative AF in patients after pulmonary resections which is not the case with digoxin; data on remaining treatments are sparse and preclude drawing definite conclusions. Disclosure: No significant relationships.
Source: Interactive CardioVascular and Thoracic Surgery - June 9, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kowalewski, M., Lewandowska, M. A., Kowalewski, J. Tags: SESSION VII: MODERATED POSTERS Source Type: research