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Condition: Ischemic Stroke
Infectious Disease: Adenoviruses
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Total 52 results found since Jan 2013.
Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3
CONCLUSIONS: This study is the first to indicate that inhibition of BRD4 delays fibrous scarring after ischemic stroke through mechanisms involving the phosphorylation of Smad2/3.PMID:36244457 | DOI:10.1016/j.brainres.2022.148126
Source: Brain Research - October 16, 2022 Category: Neurology Authors: Xuemei Li Huimin Zhu Jun Wen Jiagui Huang Yue Chen Mingfen Tian Jiangxia Ren Li Zhou Qin Yang Source Type: research
PHLDA1 promotes sevoflurane-induced pyroptosis of neuronal cells in developing rats through TRAF6-mediated activation of Rac1
In conclusion, loss of PHLDA1 protected against sevoflurane-induced pyroptosis in developing rats through inhibition of TRAF6-mediated activation of Rac1.PMID:36155068 | DOI:10.1016/j.neuro.2022.09.007
Source: Neurotoxicology - September 26, 2022 Category: Neurology Authors: Lijuan Shu Chunfu Du Source Type: research
KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA
CONCLUSIONS: Our findings confirmed that simulated p-KAP1(S824) improved the survival and proliferation of endogenous NSCs. The underlying mechanism is that highly expressed p-KAP1(S824) promotes binding to PCNA, and inhibits the binding of CUL4A to PCNA. This reduced CUL4A-mediated ubiquitination degradation to increase the stability of PCNA and promote the survival and proliferation of NSCs.PMID:35799276 | DOI:10.1186/s13287-022-02962-5
Source: Cell Research - July 7, 2022 Category: Cytology Authors: Wan Wang Tianqing Yan Xinjian Guo Heng Cai Chang Liang Linyan Huang Yanling Wang Ping Ma Suhua Qi Source Type: research
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3 β-Nrf2 pathway
CONCLUSIONS: Plin5 confers neuroprotection for neurons against OGD/R damage via effects on the Nrf2-Akt-GSK-3β pathway. This work indicates a possible role of Plin5 in cerebral ischemic stroke and the up-regulation of Plin5 is a sort of survival strategy for neurons suffering from ischemic injury.PMID:35367744 | DOI:10.1016/j.intimp.2022.108718
Source: International Immunopharmacology - April 3, 2022 Category: Allergy & Immunology Authors: Kang Huo Kai-Ge Ma Qin-Yue Guo Peng Duan Jing Xu Source Type: research
UCHL1 protects against ischemic heart injury via activating HIF-1 α signal pathway
Redox Biol. 2022 Mar 18;52:102295. doi: 10.1016/j.redox.2022.102295. Online ahead of print.ABSTRACTUbiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synuclein. In the present study, we found that UCHL1 was significantly increased in both mouse and human cardiomyocytes following myocardial infarction (MI). When LDN-57444, a pharmacological inhibitor of UCHL1, was used to treat mice subjected to MI surgery, we found that administration of LDN...
Source: Cancer Control - March 27, 2022 Category: Cancer & Oncology Authors: Bingchuan Geng Xiaoliang Wang Ki Ho Park Kyung Eun Lee Jongsoo Kim Peng Chen Xinyu Zhou Tao Tan Chunlin Yang Xunchang Zou Paul M Janssen Lei Cao Lei Ye Xuejun Wang Chuanxi Cai Hua Zhu Source Type: research
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation
CONCLUSIONS: SerpinA3N is expressed in astrocytes and penumbra neurons after stroke in mice. It reduces brain damage possibly via interacting with clusterin and inhibiting neuronal apoptosis and neuroinflammation.PMID:34897996 | DOI:10.1111/cns.13776
Source: CNS Neuroscience and Therapeutics - December 13, 2021 Category: Neuroscience Authors: Yu Zhang Qianbo Chen Dashuang Chen Wenqi Zhao Haowei Wang Mei Yang Zhenghua Xiang Hongbin Yuan Source Type: research
Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation
CONCLUSION: Overall, our study reveals the antidepressive effect of MOOs on PSD rats through modulation of microglial NLRP3 inflammasome. We also provide a novel insight into hippocampal inflammation response in PSD pathology and put forward NLRP3 inflammasome as a potential therapeutic target for PSD.PMID:34559953 | DOI:10.1111/cns.13732
Source: CNS Neuroscience and Therapeutics - September 24, 2021 Category: Neuroscience Authors: Zhifang Li Hexiang Xu Yi Xu Guanfeng Lu Qiwei Peng Jiefang Chen Rentang Bi Jianzhuang Li Shengcai Chen Hongkai Li Huijuan Jin Bo Hu Source Type: research
Issue Cover (March 2021)
Front cover:Necrostatin ‐1 (Nec‐1) has been shown to inhibit necroptosis. The mitochondrial protein Bcl‐2/adenovirus E1B 19‐kDa interacting protein 3 (BNIP3) activates a type of caspase‐independent cell death that is similar to necroptosis. Here we show that Nec‐1 is protective against death of neurons and olig odendrocytes in traumatic brain injury (TBI) in mice and in ischemic stroke in rats by inhibiting BNIP3; Nec‐1 prevents BNIP3 from integration into mitochondria to block the BNIP3 cell death pathway. The data suggest that Nec‐1 is a novel inhibitor for BNIP3.Image Content: Nec‐1 preserves structur...
Source: Journal of Neurochemistry - April 2, 2021 Category: Neuroscience Tags: Issue Cover Source Type: research
Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke
We recently reported that upregulation of the constitutively active ras homolog enriched in brain [Rheb(S16H)], which induces the activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, can protect adult neurons, mediated by the induction of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in animal models of neurodegenerative diseases. Here we show that neuronal transduction of Rheb(S16H) using adeno-associated virus serotype 1 provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Rheb(S16H)-expressing neurons exhibited neurotrophic effec...
Source: NeuroReport - August 13, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research
