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Infectious Disease: Adenoviruses

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Total 114 results found since Jan 2013.

Gene therapy of adeno-associated virus (AAV) vectors in preclinical models of ischemic stroke
CNS Neurosci Ther. 2023 Aug 8. doi: 10.1111/cns.14392. Online ahead of print.ABSTRACTStroke has been associated with devastating clinical outcomes, with current treatment strategies proving largely ineffective. Therefore, there is a need to explore alternative treatment options for addressing post-stroke functional deficits. Gene therapy utilizing adeno-associated viruses (AAVs) as a critical gene vector delivering genes to the central nervous system (CNS) gene delivery has emerged as a promising approach for treating various CNS diseases. This review aims to provide an overview of the biological characteristics of AAV vec...
Source: CNS Neuroscience and Therapeutics - August 8, 2023 Category: Neuroscience Authors: Jing Wang Mengna Zhu Jingyi Sun Lina Feng Mingfeng Yang Baoliang Sun Leilei Mao Source Type: research

Nicotine Treatment Ameliorates Blood-Brain Barrier Damage After Acute Ischemic Stroke by Regulating Endothelial Scaffolding Protein Pdlim5
AbstractAnalysis of a National Institutes of Health (NIH) trial shows that cigarette smoking protected tissue plasminogen activator (tPA)-treated patients from hemorrhage transformation (HT); however, the underlying mechanism is not clear. Damage to the integrity of the blood-brain barrier (BBB) is the pathological basis of HT. Here, we investigated the molecular events of BBB damage after acute ischemic stroke (AIS) usingin vitro oxygen-glucose deprivation (OGD) andin vivo mice middle cerebral artery occlusion (MCAO) models. Our results showed that the permeability of bEND.3 monolayer endothelial cells was significantly i...
Source: Translational Stroke Research - May 26, 2023 Category: Neurology Source Type: research

Observational Study of Patients Hospitalized With Neurologic Events After SARS-CoV-2 Vaccination, December 2020-June 2021
Discussion All cases in this study were determined to have at least 1 risk factor and/or known etiology accounting for their neurologic syndromes. Our comprehensive clinical review of these cases supports the safety of mRNA COVID-19 vaccines.
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Kim, C. Y., McNeill, E. N., Young, C., King, F., Clague, M., Caldwell, M., Boruah, A., Zucker, J., Thakur, K. T. Tags: Autoimmune diseases, Post-infectious, Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), COVID-19 Research Article Source Type: research

Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.PMID:37106272 | DOI:10.1007/s10571-023-01352-6
Source: Cellular and Molecular Neurobiology - April 27, 2023 Category: Cytology Authors: Kang-Long Zhang Shuang-Mei Li Jing-Yu Hou Ying-Hui Hong Xu-Xiang Chen Chang-Qing Zhou Hao Wu Guang-Hui Zheng Chao-Tao Zeng Hai-Dong Wu Jia-Ying Fu Tong Wang Source Type: research

Ca2+ ‐dependent activator protein for secretion 1 promotes spontaneous recovery in ischemic stroke by regulating BDNF secretion
In conclusion, CAPS1 regulates neurogenesis by upregulating BDNF release in the hippocampus, which finally facilitate spontaneous recovery after ischemic stroke.
Source: Journal of Neurochemistry - March 15, 2023 Category: Neuroscience Authors: DianWei Liu, Yan Zheng, Yuan Chen, Yang Jiang, HuiYun Wang, LingMei Li, Ling Ma Tags: ORIGINAL ARTICLE Source Type: research

microRNA ‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease
ConclusionOur findings suggest miR-221 participates in the pathological process of PD and might be a potential drug target and provide new insight into PD treatment.
Source: Brain and Behavior - February 16, 2023 Category: Neurology Authors: Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yang Tags: ORIGINAL ARTICLE Source Type: research

CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling
Transl Res. 2023 Feb 12:S1931-5244(23)00022-1. doi: 10.1016/j.trsl.2023.01.007. Online ahead of print.ABSTRACTAccording to previous studies, circular RNAs (circRNAs) are involved in multiple pathological processes of acute ischemic stroke (AIS). However, the relationship between circFOXP1 and IS has not yet been reported. Here, we found that circFOXP1 expression was significantly decreased in the peripheral blood of AIS patients compared to controls and was associated with the severity and prognosis of AIS. Functionally, knockdown and overexpression of circFOXP1 promoted and inhibited apoptotic signaling, respectively, fol...
Source: Translational Research : the journal of laboratory and clinical medicine - February 14, 2023 Category: Laboratory Medicine Authors: Jialei Yang Wanting He Lian Gu Lulu Zhu Tian Liang Xueying Liang Qingqing Zhong Ruirui Zhang Aruo Nan Li Su Source Type: research

Peroxiredoxin-3 Plays a Neuroprotective Role in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
In conclusion, PRDX3 participates in neuronal protection by inhibiting the neuronal mitochondria-mediated death pathway; PRDX3 may be an important target for EBI intervention after SAH.PMID:36566946 | DOI:10.1016/j.brainresbull.2022.12.010
Source: Brain Research - December 25, 2022 Category: Neurology Authors: Haibo Li Zongqi Wang Xueshun Xie Muyun Luo Haitao Shen Xiang Li Haiying Li Zhong Wang Xiangdong Li Gang Chen Source Type: research