Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation

CONCLUSION: Overall, our study reveals the antidepressive effect of MOOs on PSD rats through modulation of microglial NLRP3 inflammasome. We also provide a novel insight into hippocampal inflammation response in PSD pathology and put forward NLRP3 inflammasome as a potential therapeutic target for PSD.PMID:34559953 | DOI:10.1111/cns.13732

Source: CNS Neuroscience and Therapeutics - September 24, 2021 Category: Neuroscience Authors: Zhifang Li Hexiang Xu Yi Xu Guanfeng Lu Qiwei Peng Jiefang Chen Rentang Bi Jianzhuang Li Shengcai Chen Hongkai Li Huijuan Jin Bo Hu Source Type: research