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Infectious Disease: Superbugs
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Total 16 results found since Jan 2013.

Mr. M
Dr. Migliore I step off the subway, up the elevator, and up several flights of stairs. There’s a homeless man there who always uses the last stair of the lower staircase as a tray for his food. And by tray, I mean he sets his half-eaten rice burrito directly onto the step and picks around at it while I imagine the guacamole is mixing with Hep B and C. diff and MRSA. He looks up at me, I promise myself for the 100th time I’m going to start carrying cash or Kind bars or something; I give him my best sheepish face, and emerge at street level. I walk toward my hospital and pass a gentleman who sits on a ledge next to the ...
Source: The Hospitalist - December 1, 2022 Category: Hospital Management Authors: Lisa Casinger Tags: Essay Source Type: research

Characterization of an Enterococcus faecalis Bacteriophage vB_EfaM_LG1 and Its Synergistic Effect With Antibiotic
Enterococcus faecalis is a Gram-positive opportunistic pathogen that could cause pneumonia and bacteremia in stroke patients. The development of antibiotic resistance in hospital-associated E. faecalis is a formidable public health threat. Bacteriophage therapy is a renewed solution to treat antibiotic-resistant bacterial infections. However, bacteria can acquire phage resistance quite quickly, which is a significant barrier to phage therapy. Here, we characterized a lytic E. faecalis bacteriophage Vb_EfaM_LG1 with lytic activity. Its genome did not contain antibiotic resistance or virulence genes. Vb_EfaM_LG1 effectively ...
Source: Frontiers in cellular and infection microbiology - July 16, 2021 Category: Microbiology Source Type: research

Clinical features and efficacy of reperfusion therapy in minor ischemic stroke patients with atrial fibrillation
AbstractThe efficacy of reperfusion therapy (RT) using intravenous infusion of recombinant tissue plasminogen activator and/or endovascular therapy for minor ischemic stroke (MIS) has not yet been established. The present study aimed to elucidate the clinical features of MIS patients with atrial fibrillation (AF) and examine whether they could be potential candidates for RT. Data of MIS patients, defined as those with a score  ≤ 5 on the National Institute of Health Stroke Scale, were extracted from patients admitted to our hospital between 2006 and 2018, and clinical characteristics were compared between the AF and ...
Source: Journal of Thrombosis and Thrombolysis - February 10, 2020 Category: Hematology Source Type: research

Invasiveness and Clinical Outcomes of Off-Hour Admissions in Patients with Intracerebral Hemorrhage
Background: Whether time of hospital admission —during or outside regular working hours—affects functional outcome in intracerebral hemorrhage (ICH) is unestablished as previous analyses have focused on mortality only. We here investigate whether on- versus off-hour hospital admission in ICH is associated with levels of invasiveness and clin ical outcomes. Methods: Based on the UKER registry (NCT03183167) we grouped ICH-patients according to on- versus off-hour hospital admission. Primary outcome measures was functional outcome after 3 months using the modified Rankin scale (mRS) dichotomized into favorable (mRS = ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2019 Category: Neurology Authors: Anne Mrochen, Maximilian I. Spr ügel, Stefan T. Gerner, Dominik Madžar, Joji B. Kuramatsu, Philip Hoelter, Hannes Lücking, Stefan Schwab, Hagen B. Huttner Source Type: research

“A contemporary description of staphylococcus aureus prosthetic valve endocarditis. Differences according to the time elapsed from surgery”
Staphylococcus aureus prosthetic valve endocarditis (SAPVE) has a poor prognosis. There are no large series that accurately describe this entity. This is a retrospective observational study on a prospective cohort from 3 Spanish reference hospitals for cardiac surgery, including 78 definitive episodes of left SAPVE between 1996 and 2016. Fifty percent had a Charlson Index score>5; 53% were health care-related. Twenty percent did not present fever. Complications at diagnosis included: severe heart failure (HF, 29%), septic shock (SS, 17.9%), central nervous system abnormalities (19%), septic metastasis (4%). Hemorrhagic s...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Clinical and radiological characteristics and predictors of outcome of cerebral venous sinus thrombosis, a hospital-based study
AbstractCerebral venous sinus thrombosis is an uncommon cause of stroke, which is more prevalent in Iran and the Middle East. We aimed to assess the etiology, radiologic, and clinical manifestations of cerebral venous sinus thrombosis, specifically the predictors of patients ’ outcome in Namazi hospital, Shiraz, Iran. In this retrospective study, we included all adult patients with the diagnosis of cerebral venous sinus thrombosis, who were admitted in hospital, from 2012 to 2016. Demographic data, radiologic findings, clinical presentation, risk factors, treatment, a nd outcome according to modified Rankin Scale (mRS) o...
Source: Acta Neurologica Belgica - September 3, 2018 Category: Neurology Source Type: research

Evaluation of functional outcome measured by modified Rankin scale in rtPA treated patients with acute ischemic stroke.
Authors: Georgievski-Brkic B, Savic M, Nikolic D, Nikcevic L, Vukicevic M, Kozic D Abstract Aim of our study was to assess functional outcome measured by modified Rankin scale (mRS) in patients that were treated with thrombolytic therapy-recombinant tissue plasminogen activator (rtPA) after acute ischemic stroke. The study included 100 participants that were treated after acute ischemic stroke. Analyzed parameters included: gender; age groups: age 54 and below (Groupup to-54), 55-64 (Group55-64), 65-74 (Group65-74), and 75 and above (Group75-up); cerebral blood flow (CBF) and cerebral blood volume (CBV). Considerin...
Source: Archives Italiennes de Biologie - March 23, 2017 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Effective management of patients with acute ischemic stroke based on lean production on thrombolytic flow optimization
In this study, we aimed to determine whether applying lean principles to flow optimization could hasten the initiation of thrombolysis. A multidisciplinary team (Stroke Team) was organized to implement an ongoing, continuous loop of lean production that contained the following steps: decomposition, recognition, intervention, reengineering and assessment. The door-to-needle time (DNT) and the percentage of patients with DNT ≤ 60 min before and after the adoption of lean principles were used to evaluate the efficiency of our flow optimization. Thirteen patients with AIS in the pre-lean period and 43 patients with AIS in...
Source: Australasian Physical and Engineering Sciences in Medicine - April 18, 2016 Category: Biomedical Engineering Source Type: research

Healthcare circuits and functional outcomes 3 and 12 months after a stroke in a population-based cohort of 929 patients
In this study, carried out with an exhaustive population within a region and a one-year follow-up with few missing data, the results show a morbi-mortality after stroke higher than the one reported in previous studies. The results also confirm the better prognosis of IS.
Source: Annals of Physical and Rehabilitation Medicine - October 2, 2015 Category: Rehabilitation Source Type: research

Nuclear factor-¿B activation in perihematomal brain tissue correlates with outcome in patients with intracerebral hemorrhage
Background: Nuclear factor-κB (NF-κB) plays an important role in the inflammatory response after intracerebral hemorrhage (ICH). We therefore proposed that NF-κB activation in perihematomal brain tissue might correlate with clinical outcome in patients with ICH. To confirm this, we studied clinical data of 45 patients with ICH and NF-κB activation in perihematomal brain tissue and analyzed predictors of clinical outcome as well as the predictive value of NF-κB activation. Methods: Forty-five patients with spontaneous basal ganglia hemorrhage were prospectively investigated. The clinical data were collected, which incl...
Source: Journal of Neuroinflammation - March 15, 2015 Category: Neurology Authors: Ze-Li ZhangYu-Guang LiuQi-Bing HuangHong-Wei WangYan SongZhen-Kuan XuFeng Li Source Type: research

Nuclear factor-κB activation in perihematomal brain tissue correlates with outcome in patients with intracerebral hemorrhage
Background: Nuclear factor-κB (NF-κB) plays an important role in the inflammatory response after intracerebral hemorrhage (ICH). We therefore proposed that NF-κB activation in perihematomal brain tissue might correlate with clinical outcome in patients with ICH. To confirm this, we studied clinical data of 45 patients with ICH and NF-κB activation in perihematomal brain tissue and analyzed predictors of clinical outcome as well as the predictive value of NF-κB activation. Methods: Forty-five patients with spontaneous basal ganglia hemorrhage were prospectively investigated. The clinical data were collected, which incl...
Source: Journal of Neuroinflammation - March 15, 2015 Category: Neurology Authors: Ze-Li ZhangYu-Guang LiuQi-Bing HuangHong-Wei WangYan SongZhen-Kuan XuFeng Li Source Type: research

CDC's Mission: Protecting the Health of Americans
There is no doubt Ebola will rank as the biggest public health story of 2014, both here in the United States and around the world: more people sickened by Ebola than ever before in history, more people dying, and more understanding of how the health of one nation affects the health of us all. Today, more than 170 of CDC's top health professionals are in West Africa working to stop the current Ebola epidemic and leave behind stronger public health systems. Many hundreds more support their work at home. Leaving behind better capacities to find, stop, and prevent health threats in affected countries will help prevent the ...
Source: Healthy Living - The Huffington Post - December 24, 2014 Category: Consumer Health News Source Type: news

CDC National Health Report: Leading Causes of Morbidity and Mortality and Associated Behavioral Risk and Protective Factors-United States, 2005-2013.
This report reviews population health in the United States and provides an assessment of recent progress in meeting high-priority health objectives. The health status indicators described in this report were selected because of their direct relation to the leading causes of death and other substantial sources of morbidity and mortality and should be the focus of prevention efforts. REPORTING PERIOD COVERED: Data are reported starting in 2005 (or the earliest available year since 2005) through the current data year. Because data sources and specific indicators vary regarding when data are available, the most recent yea...
Source: MMWR Surveill Summ - October 31, 2014 Category: Epidemiology Authors: Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA Tags: MMWR Surveill Summ Source Type: research

The value of the use of plasma B-type natriuretic peptide among acute ischemic stroke patients in a Chinese emergency department
In this study, 142 of 238 acute ischemic stroke patients met the study criteria [mean age 70.84±11.48 years, 74 (52.11%) female]. Of the 142 patients, 35.92% were diagnosed with LAA at discharge, 25.35% with CE, 27.46% with SAO, 11.27% with SOE or SUE. Age, previous cardiac disease, atrial fibrillation, the length of hospital stays, SSS score on admission≤25 and mRS≥3 or death at discharge were all significantly higher in the CE patients compared to other subtypes (p
Source: Clinical Neurology and Neurosurgery - March 21, 2013 Category: Neurosurgery Authors: Wu Zhixin, Yang Lianhong, Huang Wei, Li Lianda, Jiang Longyuan, Zhang Yingjian, Wang Jinliang, He Mingfeng Tags: Original articles Source Type: research