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Specialty: Neurology
Source: Neurological Research
Condition: Ischemic Stroke
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Total 364 results found since Jan 2013.
Family history of stroke and death or vascular events within one year after ischemic stroke.
CONCLUSION: This study suggests that maternal stroke history, age<55 years at stroke onset and thrombotic stroke in the patients with a family history are associated with poor outcomes after stroke. Further studies from other samples are needed to replicate our findings due to a reason for excluding some severe stroke patients in this study.
PMID: 30829563 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.
CONCLUSIONS: Our study suggests that low-dose intravenous rt-PA for high-risk sICH stroke in Chinese patients may not decrease the incidence of sICH, and concomitant with a poor outcome compared to standard-dose rt-PA.
ABBREVIATIONS: rt-PA: recombinant tissue plasminogen activator; AIS: acute ischemic stroke; sICH: symptomatic intracranial haemorrhage.
PMID: 30822264 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
DISCUSSION: Our findings suggested that three times or more per week of high-intensity preconditioning exercise exert neuroprotective effects through the downregulation of the Bax/Bcl-2 ratio and caspase-3 activation after stroke.
ABBREVIATIONS: TUNEL: terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick and labeling; MCAO:middle cerebral artery occlusion; BAX:Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; TTC: 2,3,5-triphenyltetrazorlium chloride.
PMID: 30822224 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Exposure to female estrous is beneficial for male mice against transient ischemic stroke.
CONCLUSION: Exposure to female estrous reduces mortality and improves functional recovery in MCAO male mice. The study provides the first evidence to support the importance of female interaction to male stroke rehabilitation.
ABBREVIATIONS: GAP-43: growth-associated protein-43; SYP: Synaptophysin; MCAO: middle cerebral artery occlusion; OVXs: ovariectomies; CCA: common carotid artery; ECA: external carotid artery; EFE: estrous female exposure; TTC: 2,3,5-triphenyltetrazolium chloride; PAGE: polyacrylamide gel electrophoresis; PVDF: polyvinylidene difluoride; ANOVA: analysis of variance; LSD: least significant differenc...
Source: Neurological Research - March 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.
CONCLUSION: The TRPM6 rs2274924 polymorphism may be associated with susceptibility to epilepsy following stroke, and the C allele may be associated with increased risk of post-stroke epilepsy. The TRPM6 rs2274924 polymorphism may also influence serum levels of Mg2+ in post-stroke epilepsy patients.
PMID: 30739590 [PubMed - as supplied by publisher]
Source: Neurological Research - February 12, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.
CONCLUSIONS: Septic embolic stroke caused brain abscesses, increased mortality and upregulated Orm1 and Cxcl2 gene expressions compared to non-infected embolic stroke. The dramatic Orm1 increase observed in the septic group is unprecedented and suggests a significant biological role of Orm1 during septic neuroinflammation.
PMID: 30707086 [PubMed - as supplied by publisher]
Source: Neurological Research - February 4, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Portable fibrobronchoscopic treatment for non-severe ischemic stroke-associated pneumonia patients with dysphagia: a pilot study.
CONCLUSION: Sputum suction and alveolar lavage with portable fibrobronchoscope can significantly improve the hypoxia and pulmonary infections, reduce the inflammatory response, and thus improve the prognosis, rendering suction and alveolar lavage with portable fibrobronchoscope as a safe and effective treatment for non-severe ischemic SAP patients with dysphagia.
PMID: 30657017 [PubMed - as supplied by publisher]
Source: Neurological Research - January 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.
CONCLUSIONS: HUA independently predicted poor in-hospital outcome of AIS in diabetic patients, especially in patients aged ≤ 75 years.
PMID: 30526444 [PubMed - as supplied by publisher]
Source: Neurological Research - December 13, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting.
This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group.
PMID: 30433861 [PubMed - as supplied by publisher]
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Serum leptin is associated with first-ever ischemic stroke, lesion size and stroke severity in a Chinese cohort.
CONCLUSION: Serum leptin is associated with first-ever AIS, lesion size and stroke severity in a Chinese cohort.
PMID: 30433860 [PubMed - as supplied by publisher]
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
CONCLUSION: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding.
PMID: 30417762 [PubMed - as supplied by publisher]
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research
D-dimer > 2.785 μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.
CONCLUSIONS: D-dimer >2.785 μg/ml may be an effective cutoff value and a sensitive index for identifying CAIS patients. AMBIs in ≥3 vascular territories and AMBIs in both the anterior and posterior circulations are two imaging characteristics of CAIS.
PMID: 30317943 [PubMed - in process]
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Lp-PLA2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis.
Authors: Wang Y, Hu S, Ren L, Lei Z, Lan T, Cai J, Li C
Abstract
INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is still unclear. The aim of this study is to identify the relationship between Lp-PLA2 levels and early neurological deterioration (END) in acute ischemic stroke patients with Trial of Org 10 172 in Acute Stroke Treatment (TOAST) subtype of large arterial atherosclerosis (LAA).
METHODS: We enrolled Chinese patients with first ever acute ischemic stroke admitt...
Source: Neurological Research - October 10, 2018 Category: Neurology Tags: Neurol Res Source Type: research
The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.
CONCLUSIONS: The present study indicates that there were significant changes of inflammatory responses during the neuroprotection induced by RIPostC in stroke mice.
PMID: 30281410 [PubMed - as supplied by publisher]
Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research
The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
CONCLUSION: Pathogenesis of AF is involved abnormal changes of hemostasis, endothelial dysfunction, antithrombotic state and inflammation. The homeostatic markers, which play role in these pathways, and the presence of BMBs could use to form a prognostic clinic assessment tool to predict bleeding risk.
PMID: 30207930 [PubMed - as supplied by publisher]
Source: Neurological Research - September 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research
