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Specialty: Neurology
Source: Neurological Research
Condition: Ischemic Stroke
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Total 364 results found since Jan 2013.
Risk of hemorrhagic transformation after ischemic stroke in patients with antiphospholipid antibody syndrome.
CONCLUSION: APS is an independent risk factor for hemorrhagic transformation in both thrombolytic and non-thrombolytic treated patients. APS is also associated with longer length and cost of hospital stay. Further research is warranted to identify the unique risk factors in these patients to identify strategies to reduce the risk of hemorrhagic transformation in this subgroup of the population.
PMID: 28475479 [PubMed - as supplied by publisher]
Source: Neurological Research - May 8, 2017 Category: Neurology Tags: Neurol Res Source Type: research
The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains.
DISCUSSION: The results indicate that the 15-LO-1/15-HETE system promotes angiogenesis in ischemic brains by upregulation of VEGF, representing a potential target for improving neurobehavioral recovery after cerebral ischemic stroke.
PMID: 28460604 [PubMed - as supplied by publisher]
Source: Neurological Research - May 5, 2017 Category: Neurology Tags: Neurol Res Source Type: research
CT perfusion in predicting the morbidity and prognosis of hypoxic-ischemic encephalopathy after off-pump coronary artery bypass grafting.
CONCLUSION: The difference in occipital lobe rTTP on CTA perfusion may be a potential predictor of HIE. Furthermore, abnormal CT and rTTP may be used for predicting the prognosis in HIE patients. Three principal components (F1 as a reflection of CBF, F2 as reflection of TTP, F3 as a reflection of MTT) can be used to generally describe perfusion parameters.
PMID: 28454490 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Identification of IL-17A-derived neural cell type and dynamic changes of IL-17A in serum/CSF of mice with ischemic stroke.
CONCLUSION: We firstly reported astrocytic IL-17A peaks in CSF within 12 h and in serum at 3 d reperfusion after ischemic stroke. IL-17A may exaggerate neuronal injuries through its receptor IL-17R at early stage of ischemic stroke.
PMID: 28441917 [PubMed - as supplied by publisher]
Source: Neurological Research - April 28, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Validation of the Essen Stroke Risk Score in different subtypes of ischemic stroke.
CONCLUSIONS: In patients with LAA subtype of non-atrial fibrillation stroke, the ESRS has moderate accuracy in stratifying the risk of both recurrent strokes and major vascular events within the first year. However, the ESRS couldn't accurately stratify the risk of recurrent strokes in patients with small-artery atherosclerosis subtype of non-atrial fibrillation stroke.
PMID: 28431475 [PubMed - as supplied by publisher]
Source: Neurological Research - April 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Persistence of secondary prevention medication and related factors for acute ischemic stroke and transient ischemic attack in China.
CONCLUSIONS: More than half of patients with AIS and TIA reported discontinuing one or more secondary prevention medications within 3 months of hospital discharge. Several factors associated with medication persistence were identified. Here, we propose strategies that could be implemented to improve the quality of secondary prevention.
PMID: 28420316 [PubMed - as supplied by publisher]
Source: Neurological Research - April 21, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Exercise rehabilitation immediately following ischemic stroke exacerbates inflammatory injury.
CONCLUSION: Post-stroke exercise, if too early, may result in elevated levels of cell stress and increased expression of pro-inflammatory cytokines, which may amplify the tissue damage associated with cerebral ischemia/reperfusion injury. The results shed light on the manner in which exercise initiation timing may affect post-stroke rehabilitation.
PMID: 28415917 [PubMed - as supplied by publisher]
Source: Neurological Research - April 20, 2017 Category: Neurology Tags: Neurol Res Source Type: research
The association between high on-treatment platelet reactivity and early recurrence of ischemic events after minor stroke or TIA.
DISCUSSION: In patients with minor stroke or TIA, the prevalence of HTPR was 22.7%, and HTPR was independently associated with recurrent ischemic events.
PMID: 28398139 [PubMed - as supplied by publisher]
Source: Neurological Research - April 13, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Impact of CRP gene and additional gene-smoking interaction on ischemic stroke in a Chinese Han population.
CONCLUSIONS: We found that rs2794521, rs3093059, and rs1205 were associated with decreased IS risk; we also found that gene-gene interaction between rs2794521 and rs3093059, and gene-environment interaction between rs2794521 and smoking were associated with decreased IS risk.
PMID: 28287042 [PubMed - as supplied by publisher]
Source: Neurological Research - March 14, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.
CONCLUSION: These results showed that UTI protected the brain against ischemic injury which may be due to the alleviation of inflammation reaction in early stage through downregulating TLR4 and NF-κB expression.
PMID: 28191863 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population.
CONCLUSIONS: Our results support an important association of rs966221 and rs12188950 minor allele and its interaction with increased risk of IS risk, and additional interaction between rs966221 and smoking.
PMID: 28191858 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
DISCUSSION: Dl-3-n-butylphthalide could significantly improve the cognitive function of AIS patients 1 month after stroke. Hcy was involved in the incidence of VD 1 month after AIS. However, further studies are necessary because of differences between groups at baseline.
PMID: 28145815 [PubMed - as supplied by publisher]
Source: Neurological Research - February 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Atherosclerotic plaque burden of middle cerebral artery and extracranial carotid artery characterized by MRI in patients with acute ischemic stroke in China: association and clinical relevance.
CONCLUSION: Greater atherosclerotic plaque burden and a closer association with stroke severity were found for the MCA as compared to the ipsilateral ECA. Identification of MCA plaque lesions by MRI may be helpful for developing more aggressive strategies for stroke prevention.
PMID: 28136710 [PubMed - as supplied by publisher]
Source: Neurological Research - February 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research
ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population.
This study aims to evaluate the potential association of the single nucleotide polymorphisms (SNPs) of ARHGEF10 with ischemic stroke (IS) in northern Han Chinese population. Three SNPs of ARHGEF10 gene were analyzed in 385 IS patients and 362 hypertension control patients using the ligase detection reaction (LDR) method. Logistic regression analysis demonstrated that GG genotypes of SNP rs2280887 were associated with an increased risk of IS in dominant, recessive, and additive models. Moreover, SNP rs9657362 and SNP rs4480162 were significantly associated with IS in dominant and additive models. These results indicate that...
Source: Neurological Research - December 11, 2016 Category: Neurology Tags: Neurol Res Source Type: research
Rosuvastatin prevents aortic arch plaque progression and improves prognosis in ischemic stroke patients.
DISCUSSION: Rosuvastatin therapy prevented aortic arch plaque progression in IS patients with CAP, and may also have long-term clinical benefits.
PMID: 27915586 [PubMed - as supplied by publisher]
Source: Neurological Research - December 7, 2016 Category: Neurology Tags: Neurol Res Source Type: research
