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Dihydromyricetin alleviates cerebral ischemia-reperfusion injury by attenuating apoptosis and astrogliosis in peri-infarct cortex
This study investigates the potential of DHM, given postreperfusion in middle cerebral artery occlusion (MCAo) model of stroke in rats.METHODS: MCAo surgery was performed in male Wistar rats. Reperfusion was performed after 90 min of ischemia. DHM (50 and 100 mg/kg) was administered 10-15 min and 2 h postreperfusion followed by daily dosing for 2 more days. Neurobehavioral parameters and infarct size (TTC staining) were assessed after 72 h. The effective dose (100 mg/kg) was then used to study reduction in infarct size (measured by MRI) and effect on apoptosis (evaluated by protein expression of Bax, Bcl-2 and cleaved casp...
Source: Neurological Research - December 9, 2021 Category: Neurology Authors: Himika Wasan Devendra Singh Balu Joshi Deepti Upadhyay Uma Sharma Amit Kumar Dinda K H Reeta Source Type: research

Factors associated with early improvement after intravenous thrombolytic treatment in acute ischemic stroke
CONCLUSION: : Management of factors associated with ENI and determination of treatment strategies accordingly are important for obtaining a better clinical outcome. It can help quickly select patients, who, even though they will not respond to rt-PA, may be appropriate candidates for bridging therapy.PMID:34706632 | DOI:10.1080/01616412.2021.1996980
Source: Neurological Research - October 28, 2021 Category: Neurology Authors: Nurcan Akbulut Vesile Ozturk Suleyman Men Atakan Arslan Zeynep Tuncer Iss ı Erdem Yaka Kursad Kutluk Source Type: research

The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats
CONCLUSION: That blockade of Shh signaling concurrently with the creation of a lesion aggravated ischemic myelin damage, probably via its downstream effects on Olig1 transcription. Shh plays a contributory role during regeneration in the CNS, thereby providing promising new therapeutic strategies to assist in recovery from ischemic stroke.PMID:34592910 | DOI:10.1080/01616412.2021.1981106
Source: Neurological Research - October 1, 2021 Category: Neurology Authors: Hong Zhao Xiao-Yu Gao Xiao-Jun Wu Yong-Bo Zhang Xun-Fen Wang Source Type: research

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