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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Effect of Sodium-Glucose Cotransporter Inhibitors on Major Adverse Cardiovascular Events and Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus and Atrial Fibrillation
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to lower cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risks. Here, we aimed to evaluate the effect of SGLT2 inhibitors on major adverse cardiovascular events (MACE), a composite of cardiovascular mortality, myocardial infarction, or ischemic stroke and hospitalization for heart failure in patients with T2DM and atrial fibrillation (AF). Using the Korean National Health Insurance Service database, we identified 40,268 patients with T2DM and AF who were newly prescribed oral hypoglycemic drugs ...
Source: The American Journal of Cardiology - July 7, 2022 Category: Cardiology Authors: Chang Hee Kwon, Ye-Jee Kim, Min-Ju Kim, Myung-Jin Cha, Min Soo Cho, Gi-Byoung Nam, Kee-Joon Choi, Jun Kim Source Type: research
Intermediate-Term Outcomes After Transcatheter Aortic Valve Implantation in Patients With a History of Atrial Fibrillation
Patients who underwent transcatheter aortic valve implantation (TAVI) with a history of atrial fibrillation (AF) have higher rates of all-cause mortality, inpatient complications, and length of hospitalization.1 –3 However, intermediate-term outcomes and the impact of stroke risk as calculated by CHA2DS2-VASc scores in the AF population who underwent TAVI have not previously been described. We aimed to evaluate intermediate-term outcomes in patients who underwent TAVI with a history of AF as stratified by CHA2DS2-VASc scores.
Source: The American Journal of Cardiology - July 4, 2022 Category: Cardiology Authors: Craig C. Morris, Kris Kumar, Ashraf Samhan, Philip Blatt, Tessa Herman, Trisha Chau, Gurion Lantz, Scott M. Chadderdon, Howard K. Song, Firas E. Zahr, Harsh Golwala Source Type: research
Association Between Periodontal Disease and Cardiovascular Disease (from the NHANES)
As observational studies support the association between periodontal disease (PD) and cardiovascular diseases (CVDs), we examined this relationship using the National Health and Nutrition Examination Survey 2013 to 2014 data. This cross-sectional study involved 2,830 adult participants, aged ≥30 years who underwent a home interview, followed by a standardized assessment at a mobile examination center from 2013 to 2014. PD was defined using the new classification scheme issued by American Academy of Periodontology Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions in 2017, and CVD was ...
Source: The American Journal of Cardiology - June 27, 2022 Category: Cardiology Authors: Kyari Sumayin Ngamdu, Indika Mallawaarachchi, Eric A. Dunipace, Lin-Hsin Chuang, S. Hammad Jafri, Nishant R. Shah, Youjin N. Jeong, Alan R. Morrison, Deepak L. Bhatt Source Type: research
Transcatheter and Surgical Aortic Valve Implantation in Children, Adolescents, and Young Adults With Congenital Heart Disease
Transcatheter aortic valve implantation (TAVI) is common in adults but rare in children and adolescents. Since 2014, our institution has incorporated a transcatheter approach as an option for aortic valve replacement in this population. The purpose of this study was to compare short-term outcomes of TAVI with surgical aortic valve replacement (SAVR). This single-center, retrospective study included patients aged 10 to 21 years who had a native SAVR or TAVI between January 2010 to April 2020. Comparative analysis of baseline characteristics and a composite outcome (stroke within 6 months, readmission within 30 days, death) ...
Source: The American Journal of Cardiology - June 9, 2022 Category: Cardiology Authors: Dwight M. Robertson, Dana M. Boucek, Mary Hunt Martin, Robert G. Gray, Eric R. Griffiths, Aaron W. Eckhauser, Zhining Ou, Linda M. Lambert, Richard V. Williams, S. Adil Husain Source Type: research
Comparison of Dabigatran Versus Warfarin Treatment for Prevention of New Cerebral Lesions in Valvular Atrial Fibrillation
Warfarin is the standard anticoagulation therapy for valvular atrial fibrillation (AF); however, new oral anticoagulants have emerged as an alternative. We compared the efficacy and safety of dabigatran with conventional treatment in AF associated with left-sided valvular heart disease (VHD), including mitral stenosis (MS). Patients with AF and left-sided VHD were randomly assigned to receive dabigatran or conventional treatment. The primary end point was the occurrence of clinical stroke or a new brain lesion (silent brain infarct and microbleed) on 1-year follow-up brain magnetic resonance imaging.
Source: The American Journal of Cardiology - May 9, 2022 Category: Cardiology Authors: Min Soo Cho, Minsu Kim, Seung-ah Lee, Sahmin Lee, Dae-Hee Kim, Jun Kim, Jong-Min Song, Gi-Byoung Nam, Sang Joon Kim, Duk-Hyun Kang, Kee-Joon Choi Source Type: research
Impact of Cerebral Embolic Protection Devices on the Incidence and Outcomes of Delirium After Transcatheter Aortic Valve Implantation
Postoperative delirium is a well-recognized complication after transcatheter aortic valve implantation (TAVI) that is associated with a significantly increased mortality and prolonged hospitalization stay.1 Ischemic brain injury has been hypothesized to be one of the predominant mechanisms responsible for delirium after TAVI. Brain injury during TAVI involves microinfarctions caused by cerebral embolization of the aortic plaque or valve particles dislodged during the prosthesis deployment.1,2 The role of cerebral embolic protection (CEP) devices has been studied in preventing stroke during TAVI.
Source: The American Journal of Cardiology - April 15, 2022 Category: Cardiology Authors: Agam Bansal, Anirudh Kumar, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, Axel Linke, James Yun, Samir R. Kapadia Source Type: research
Impact of Timing and Treatment Strategy on Coronary Perforation During Percutaneous Coronary Intervention for Chronic Total Occlusion
This study aimed to describe the clinical characteristics and timing of perforations during CTO-PCI. Data from the Japanese CTO-PCI expert registry included 8,760 patients who underwent CTO-PCI between January 2014 and January 2019. The major adverse cardiac and cerebrovascular events were defined as death, tamponade, myocardial infarction, stent thrombosis, stroke, and revascularization.
Source: The American Journal of Cardiology - April 14, 2022 Category: Cardiology Authors: Katsuya Miura, Hiroyuki Tanaka, Koichi Kishi, Toshiya Muramatsu, Hisayuki Okada, Yuji Oikawa, Tomohiro Kawasaki, Ryohei Yoshikawa, Atsunori Okamura, Etsuo Tsuchikane Source Type: research
Low Blood Pressure Threshold for Adverse Outcomes During Left Ventricular Assist Device Support
It has been suggested that maintaining low mean arterial pressure (MAP) in left ventricular assist device (LVAD) recipients is associated with a reduced risk of stroke/death. However, the lower limit of the optimal MAP range has not been established. We aimed to identify this lower limit in a contemporary cohort of LVAD recipients with frequent longitudinal MAP measurements. We analyzed 86,651 MAP measurements in 309 patients with an LVAD (32% LVADs with full magnetic levitation of the impeller) at a tertiary medical center during a mean follow-up of 1.7 ± 1.1 years.
Source: The American Journal of Cardiology - April 7, 2022 Category: Cardiology Authors: Himabindu Vidula, Onur Altintas, Scott McNitt, Adam D. DeVore, Edo Y. Birati, Michael V. Genuardi, Farooq H. Sheikh, Bronislava Polonsky, Jeffrey D. Alexis, Igor Gosev, John D. Bisognano, Valentina Kutyifa, Abraham Seidmann, Ilan Goldenberg Source Type: research
Meta-Analysis Comparing Percutaneous Closure Versus Medical Therapy for Patent Foramen Ovale
Patent foramen ovale (PFO) is the most common congenital heart defect with an estimated prevalence of 1 in 4 adults. The optimal treatment strategy for patients with PFO with cryptogenic stroke has long been debated. Early clinical trials, including Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT) (NCT00465270), Patent Foramen Ovale and Cryptogenic Embolism (PC) (NCT00166257), and Evaluation of the STARFlex Septal Closure System in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen O...
Source: The American Journal of Cardiology - April 5, 2022 Category: Cardiology Authors: Chayakrit Krittanawong, Hafeez Ul Hassan Virk, Anirudh Kumar, Zhen Wang, Dhruv Mahtta, Umair Khalid, Ali E. Denktas, John J. Volpi, Hani Jneid Source Type: research
Meta-Analysis of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Left Main Narrowing
Randomized controlled trials (RCTs) comparing percutaneous coronary intervention (PCI) with drug-eluting stents and coronary artery bypass grafting (CABG) for patients with left main coronary artery disease (LMCAD) have reported conflicting results. We performed a systematic review up to May 23, 2021, and 1-stage reconstructed individual patient data meta-analysis (IPDMA) to compare outcomes between both groups. The primary outcome was 10-year all-cause mortality. Secondary outcomes included myocardial infarction (MI), stroke, and unplanned revascularization at 5 years.
Source: The American Journal of Cardiology - April 4, 2022 Category: Cardiology Authors: Nicholas W.S. Chew, Chen-Han Ng, Gwyneth Kong, Keng-Siang Lee, Darren J.H. Tan, Oliver Zi-Hern Lim, Yip Han Chin, Bee Choo Tai, Tianyuan Gu, Seung-Jung Park, Duk-Woo Park, Marie-Claude Morice, Theodoros Kofidis, James W.L. Yip, Poay-Huan Loh, Koo-Hui Chan Source Type: research
Relation of Hemoglobin A1C Levels to Risk of Ischemic Stroke and Mortality in Patients With Diabetes Mellitus and Atrial Fibrillation
This study aimed to assess the incidence and risks of ischemic stroke and mortality according to baseline HbA1c levels in patients with DM and AF. We conducted a cohort study using Clalit Health Services electronic medical records. The study population included all Clalit Health Services members aged ≥25 years, with the first diagnosis of AF between January 1, 2010, and December 31, 2016, who had a diagnosis of DM.
Source: The American Journal of Cardiology - March 29, 2022 Category: Cardiology Authors: Louise Kezerle, Moti Haim, Amichay Akriv, Adi Berliner Senderey, Asaf Bachrach, Maya Leventer-Roberts, Meytal Avgil Tsadok Source Type: research
Meta-Analysis Comparing Carotid Artery Stenting With Endarterectomy for Asymptomatic Carotid Artery Stenosis
Carotid artery stenosis is responsible for 1/3 of cases of stroke annually.1 –3 Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are 2 established interventions for treating symptomatic carotid artery stenosis. Recently, the ACST-2 trial (Second Asymptomatic Carotid Surgery Trial) compared the 2 techniques among patients with asymptomatic carotid artery steno sis and showed similar postprocedural and long-term outcomes.3 This refueled the heated discussion regarding the safety and efficacy of CEA versus CAS in patients with asymptomatic carotid artery stenosis.
Source: The American Journal of Cardiology - March 22, 2022 Category: Cardiology Authors: Mian Tanveer Ud Din, Mohamed M.G. Mohamed, Syed Yahya Shah, Ahmel Arshad, Ayman Ahmed, Mohammed Osman Source Type: research
Age-Related Disparity Trends in Stroke-Related Mortality in the United States, 1999 to 2019
Stroke hospitalizations and mortality have declined in older subjects in the United States; however, acute ischemic stroke hospitalizations have increased in subjects 25 to 64 years of age.1,2 Regardless of increasing acute ischemic stroke hospitalization trends in young patients, population-based estimates and trends of stroke (including hemorrhagic and ischemic stroke) related mortality stratified by age groups are currently scarce. Therefore, in this study, we assess ed trends in stroke mortality rates in varying age groups over 2 decades in the United States.
Source: The American Journal of Cardiology - February 28, 2022 Category: Cardiology Authors: Rochell Issa, Abdul Mannan Khan Minhas, Robert W. Ariss, Salik Nazir, Hiba Rehman, Waleed Tallat Kayani, Salim S. Virani Source Type: research
Derivation and Validation of a Clinical Score for Predicting Postoperative Atrial Fibrillation in Noncardiac Elective Surgery (the HART Score)
Postoperative atrial fibrillation (POAF) represents the most frequent cardiac arrhythmia in the surgical setting. It affects almost 3% of all patients over 45 years old who underwent noncardiovascular surgery and is associated with a higher risk of stroke, heart failure, myocardial infarction, and cardiac arrest. The study aimed to assess independent predictors of POAF and derive and validate a score for risk prediction in clinical practice. This was a retrospective cohort study including all consecutive candidates to all types of noncardiac elective surgery attending a cardiological preoperative assessment from 2016 to 2019.
Source: The American Journal of Cardiology - February 23, 2022 Category: Cardiology Authors: Giulia Stronati, Carlo Mondelli, Alessia Urbinati, Giuseppe Ciliberti, Alessandro Barbarossa, Paolo Compagnucci, Michela Casella, Antonio Dello Russo, Federico Guerra Source Type: research
Impact of Timing of Infective Endocarditis After Transcatheter Aortic Valve Implantation on Mortality
It is well established that infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is associated with significantly increased mortality (1-year mortality rates as high as 50%) and stroke rates.1,2 Existing studies have determined the predictors of IE after TAVI and mortality in patients with IE after TAVI.1,2 Stortecky et al3 determined that the incidence of IE after TAVI was highest in the early procedural/periprocedural period ( ≤100 days). Similar findings were shown by Mentias et al.
Source: The American Journal of Cardiology - February 11, 2022 Category: Cardiology Authors: Agam Bansal, Anirudh Kumar, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, Samir R. Kapadia Source Type: research
