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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Long-Term Outcomes for Patients With Acute Coronary Syndrome and Nonvalvular Atrial Fibrillation
Short-term outcomes are worse for patients with acute coronary syndrome (ACS) with a history of nonvalvular atrial fibrillation (NVAF). However, long-term prognosis remains unclear. We linked administrative health databases to identify patients hospitalized with ACS (ST-elevation myocardial infarction [STEMI], non –STEMI [NSTEMI], and unstable angina) between 2008 and 2019 in Alberta, Canada. Patients were stratified according to history of NVAF before hospitalization. The primary outcome was a composite of all-cause mortality, hospitalization for myocardial infarction, or stroke at 3 years.
Source: The American Journal of Cardiology - January 7, 2022 Category: Cardiology Authors: Pishoy Gouda, Douglas C. Dover, Anamaria Savu, Kevin Bainey, Shaun G. Goodman, Robert Welsh, Padma Kaul, Roopinder Kaur Sandhu Source Type: research
Meta-Analysis of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery
We congratulate Mohamed et al1 on their meta-analysis of randomized controlled trials (RCTs) comparing surgical left atrial appendage occlusion (LAAO) to no LAAO in patients with atrial fibrillation (AF). The pooled estimate of a 33% reduction in risk of stroke or systemic embolism with LAAO (5 trials, 5,128 patients, risk ratio [RR] 0.67, 95% confidence interval [CI] 0.53 to 0.84, p
Source: The American Journal of Cardiology - January 5, 2022 Category: Cardiology Authors: Gwen E. Eagle, Richard P. Whitlock, Emilie P. Belley-C ôté Source Type: research
Meta-Analysis of 5-Year Risk of All-Cause Death or Stroke After Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement
Transcatheter aortic valve implantation (TAVI) is an established alternative to surgical aortic valve replacement (SAVR) for patients with severe symptomatic aortic stenosis.1,2 Its indication has expanded from high-risk to include a low surgical risk younger population. Although the short-term results of TAVI and SAVR in patients with intermediate or high surgical risk are similar,1,2 outcomes beyond short-term periods remain unclear. Recently, the results of 5-year follow-up of the Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI) trial has been reported, which showed a similar rate of the compos...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Yujiro Yokoyama, Toshiki Kuno, Tomo Ando, Tadahisa Sugiura, Azeem Latib Source Type: research
Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation
To compare the efficacy and safety of apixaban and rivaroxaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) by way of a meta-analysis informed by real-world evidence. Systematic review and meta-analysis of observational studies including patients with NVAF on apixaban and rivaroxaban, which reported stroke/systemic embolism and/or major bleeding. Prospero registration number: CRD42021251719. Estimates of relative treatment effect (based on hazard ratios[HRs]) were pooled using the inverse variance method.
Source: The American Journal of Cardiology - December 20, 2021 Category: Cardiology Authors: Mamas A. Mamas, Sarah Batson, Kevin G. Pollock, Sarah Grundy, Andrew Matthew, Chris Chapman, Joana Assis Manuel, Usman Farooqui, Stephen A. Mitchell Source Type: research
Effectiveness and Safety of Apixaban Versus Warfarin in Obese Patients with Nonvalvular Atrial Fibrillation Enrolled in Medicare and Veteran Affairs
Real-world studies have evaluated the use of anticoagulants in obese patients with nonvalvular atrial fibrillation (NVAF), but they have been limited by sample size or the use of diagnosis codes on claims to define obesity. This retrospective study used body weight data of ≥100 kg or a body mass index of ≥30 kg/m2 to identify elderly (aged ≥65 years) NVAF patients with obesity in dually enrolled Veterans Affairs and fee-for-service Medicare patients. It evaluated the risk of stroke/systemic embolism (SE) and major bleeding (MB) in patients that initiated apixaba n versus warfarin.
Source: The American Journal of Cardiology - December 18, 2021 Category: Cardiology Authors: Steve Deitelzweig, Janvi Sah, Amiee Kang, Cristina Russ, Madison Preib, Amol D. Dhamane, Anna Ratiu, Matthew Cato, Tamuno Alfred, Edi Levi, Manuela Di Fusco Source Type: research
Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score
We hypothesized that cannabis use is associated with cardiovascular disease (CVD) risk factors. This could explain the reported link between cannabis and cardiovascular events including stroke and myocardial infarction. This analysis included 7,159 participants (age 37.8 ± 12.4 years, 48.6% men, and 61.5% Caucasian) from the National Health and Nutrition Examination Survey years 2011 to 2018. Cannabis use was defined by self-report. Participants with a history of stroke or myocardial infarction were excluded.
Source: The American Journal of Cardiology - December 17, 2021 Category: Cardiology Authors: Travis M. Skipina, Nikhil Patel, Bharathi Upadhya, Elsayed Z. Soliman Source Type: research
Relation of Abdominal Obesity to Risk of Atrial Fibrillation (From the Reasons for Geographic and Racial Differences in Stroke REGARDS Study)
Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. We included 11,617 Black and White participants (mean age 63.0 ± 8.4 years) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) national cohort study who were free of AF at baseline. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval (CI) of incident AF associated with AO.
Source: The American Journal of Cardiology - December 11, 2021 Category: Cardiology Authors: Joonseok Kim, Pankaj Arora, Soo Y. Kwon, Vibhu Parcha, Emily B. Levitan, Byron C. Jaeger, Elsayed Z. Soliman, Virginia J. Howard Source Type: research
Direct Oral Anticoagulants in Cardiac Amyloidosis –Associated Heart Failure and Atrial Fibrillation
Atrial fibrillation (AF) is present in approximately 40% of patients with cardiac amyloidosis.1 AF in the setting of cardiac amyloidosis is associated with a significant risk of stroke and systemic thromboembolism regardless of the patient's CHA ₂DS₂-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65 to 74 years, sex category) score.2 Although current guidelines recommend anticoagulation therapy in all patients with cardiac amyloidosis and AF, data about the comparative effectiveness and safety of vitamin K antagonists (VKAs) ...
Source: The American Journal of Cardiology - November 27, 2021 Category: Cardiology Authors: Amgad Mentias, Paulino Alvarez, Pulkit Chaudhury, Michael Nakhla, Rohit Moudgil, Mohamad Kanj, Mazen Hanna, Milind Y. Desai Source Type: research
Meta-Analysis of Implantable Loop Recorder for Atrial Fibrillation Detection in Patients With Ischemic Stroke
Atrial fibrillation (AF) is the most common arrhythmia in adults and it is responsible for about one-third of all ischemic strokes.1 Although prior studies have found more frequently detected AF following stroke with longer duration of monitoring, ambiguity remains regarding the optimal duration of ambulatory cardiac monitoring.1 Therefore, we conducted a meta-analysis of solely randomized clinical trials (RCTs) to evaluate the efficacy and safety of implantable loop recorder (ILR) in AF detection, and subsequent reduction of recurrent strokes in patients with recent ischemic strokes.
Source: The American Journal of Cardiology - November 15, 2021 Category: Cardiology Authors: Babikir Kheiri, Saket Sanghai, Hani Alhamoud, Mohammed Osman, Eric Stecker, Charles A. Henrikson, Babak Nazer Source Type: research
Long-Term Variation in Kidney Function and Its Impact After Acute Myocardial Infarction
Kidney disease (KD) in patients with acute myocardial infarction (AMI) is associated with major cardiovascular events (MACE). We sought to compare the long-term variation in KD in patients with AMI versus controls and its value as a risk factor for MACE in patients with AMI. A cohort of 300 outpatients with AMI, recruited between 2014 and 2016 in Barcelona, Spain, were compared with a control cohort matched 1:1 based on age and several risk factors for developing KD. Annual estimated glomerular filtration rate (eGFR) using MDRD-4 formula and albuminuria were collected and patients were followed up for the occurrence of MAC...
Source: The American Journal of Cardiology - November 9, 2021 Category: Cardiology Authors: Eduard R ódenas-Alesina, Paolo Cabeza-Martínez, Valeria Zamora-Putin, Ivana Pariggiano, Roxana Escalona, Yassin Belahnech, Montse Delgado de la Cruz, Paolo Calabrò, Ignacio Ferreira-González, Jordi Bañeras Source Type: research
Effect of Pacemaker Implantation After Transcatheter Aortic Valve Implantation Compared to Surgical Aortic Valve Implantation
We sought to assess the impact of pacemaker implantation after transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve implantation (SAVI) cohorts. We sought to explore the long-term mortality of pacemaker implantation after TAVI or SAVI. The research letter aims to understand the long-term effect at 5 years of both mortality and stroke outcomes. Previous literature has illustrated that mortality is similar within 1 year, but further research is needed to understand if this trend holds.
Source: The American Journal of Cardiology - November 8, 2021 Category: Cardiology Authors: Frank H. Annie, Sahil Dave, Syed Muhammad, Aravinda Nanjundappa Source Type: research
Incidence and Outcomes of Pericardial Effusion/Tamponade Following Percutaneous Left Atrial Appendage Closure
Percutaneous left atrial appendage closure (LAAC) with Watchman (Boston Scientific, Marlborough, MA) has emerged as an alternative to anticoagulation for stroke prevention in patients with atrial fibrillation (AF). A US nationwide registry reported that even though the rate of major in-hospital complication of LAAC was low at 2.18%, pericardial effusion or pericardial tamponade (PE/PT) is a relatively common complication.1 In addition, case reports demonstrated the occurrence of delayed PE/PT after discharge.
Source: The American Journal of Cardiology - November 3, 2021 Category: Cardiology Authors: Toshiaki Isogai, Anas M. Saad, Shashank Shekhar, Shunsuke Kuroda, Abdelrahman I. Abushouk, Mohamed M. Gad, Oussama M. Wazni, Amar Krishnaswamy, Samir R. Kapadia Source Type: research
Meta-Analysis of Randomized Clinical Trials Comparing the Impact of Implantable Loop Recorder Versus Usual Care After Ischemic Stroke for Detection of Atrial Fibrillation and Stroke Risk
Implantable loop recorder (ILR) is recommended to detect subclinical atrial fibrillation (AF) after cryptogenic stroke; however, the clinical outcomes of this practice is unclear. We conducted a systematic review and meta-analysis of randomized controlled trials to evaluate 12-month AF detection, change in oral anticoagulation (OAC), and recurrent stroke in ILR versus usual care after ischemic stroke. We searched Medline, Embase, Web of Science, Cochrane Library for randomized controlled trials comparing ILR with usual care after any ischemic stroke.
Source: The American Journal of Cardiology - October 28, 2021 Category: Cardiology Authors: Darae Ko, Qiying Dai, David B. Flynn, Nicholas A. Bosch, Robert H. Helm, Kevin M Monahan, Charlotte Andersson, Christopher D. Anderson, Allan J. Walkey Source Type: research
Risk of Intracranial Hemorrhage Caused by Direct Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation (from a Network Meta-Analysis of Randomized Controlled Trials)
Patients with atrial fibrillation (AF) who take direct oral anticoagulants (DOACs) face the risk of intracranial hemorrhage (ICH), which can be serious and even life threatening, but the risk of ICH of anticoagulants is still controversial. In this meta-analysis, we compared the risk of ICH between vitamin K antagonists (VKAs) and DOACs. Furthermore, we also compared the risk of ICH in different DOACs. PubMed, Embase, Web of Science, and the Cochrane Library were searched for relevant randomized controlled trials.
Source: The American Journal of Cardiology - October 28, 2021 Category: Cardiology Authors: Meina Lv, Tingting Wu, Shaojun Jiang, Wenjun Chen, Jinhua Zhang Source Type: research
Outcomes of Direct Oral Anticoagulants Co-Prescribed with Common Interacting Medications
We examined the prevalence of co-prescription of DOACs with interacting medications and its impact on outcomes in patients with atrial fibrillation (AF). Patients with AF treated with a DOAC from 2010 to 2017 at the Mayo Clinic and co-prescribed medications that are inhibitors or inducers of the P-glycoprotein and/or Cytochrome P450 3A4 pathways were identified. The outcomes of stroke, transient ischemic attack, or systemic embolism, major bleeding, and minor bleeds were compared between patients with and without an enzyme inducer.
Source: The American Journal of Cardiology - October 27, 2021 Category: Cardiology Authors: David Sanborn, Alan Sugrue, Mustapha Amin, Ramila Mehta, Medhat Farwati, Abhishek J. Deshmukh, Haarini Sridhar, Azza Ahmed, Samuel J. Asirvatham, Narith N. Ou, Peter A. Noseworthy, Ammar M. Killu, Siva K. Mulpuru, Malini Madhavan Source Type: research
