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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Long-Term Follow-Up of Transcatheter Aortic Valve Implantation With Portico Versus Evolut Devices
New-generation devices such as Evolut and Portico have provided favorable results in patients who underwent transcatheter aortic valve implantation (TAVI) for aortic stenosis, but their comparative effectiveness remains debated, despite its relevance when envisioning TAVI in low-risk patients. We evaluated the safety and efficacy of 2 leading TAVI devices (Evolut and Portico) used by the same team of experienced TAVI operators, focusing on long-term outcomes, including major adverse events (i.e., the composite of death, stroke, myocardial infarction, major vascular complication, or major bleeding).
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Nicola Corcione, Giuseppe Biondi-Zoccai, Paolo Ferraro, Alberto Morello, Sirio Conte, Michele Cimmino, Carlo Vigna, Giacomo Frati, Giovanni De Persio, Luca Altamura, Fabrizio Tomai, Andrea Berni, Mauro Cassese, Martino Pepe, Arturo Giordano Source Type: research
Long-term Follow-up of Transcatheter Aortic Valve Implantation with Portico vs. Evolut devices
New-generation devices such as Evolut and Portico have provided favorable results in patients undergoing transcatheter aortic valve implantation (TAVI) for aortic stenosis, but their comparative effectiveness remains debated, despite its relevance when envisioning TAVI in low-risk patients. We evaluated the safety and efficacy of 2 leading TAVI devices (Evolut and Portico) used by the same team of experienced TAVI operators, focusing long-term outcomes, including the major adverse events (i.e. the composite of death, stroke, myocardial infarction, major vascular complication or major bleeding).
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Nicola Corcione, Giuseppe Biondi-Zoccai, Paolo Ferraro, Alberto Morello, Sirio Conte, Michele Cimmino, Carlo Vigna, Giacomo Frati, Giovanni De Persio, Luca Altamura, Fabrizio Tomai, Andrea Berni, Mauro Cassese, Martino Pepe, Arturo Giordano Source Type: research
Validation of Acute Ischemic Stroke Codes Using the International Classification of Diseases Tenth Revision
Administrative databases have increasingly become a platform for clinical investigations aiming to address trends in the prevalence, patterns of care, and outcomes of major cardiovascular diseases including strokes1-4. Identification of acute ischemic stroke (AIS) events in these databases is dependent on billing codes. Hence, accurate querying of administrative databases for research purposes require proper validation of those billing codes. Several studies have previously validated the use of certain International Classification of Diseases-Ninth Revision-Clinical Modification (ICD-9-CM) codes to discern hospitalizations for AIS.
Source: The American Journal of Cardiology - January 7, 2020 Category: Cardiology Authors: Mohamed Alhajji, Akram Kawsara, Mohamad Alkhouli Source Type: research
Meta-analysis Evaluating Calcium Channel Blockers and the Risk of Peripheral Arterial Disease in Patients with Hypertension
Peripheral arterial disease (PAD) is associated with significant morbidity and mortality. It affects 8.5 million Americans aged 40 years and above, and 202 million people worldwide.1 Given the significant burden and resource utilization associated with PAD, strategies for preventing the development of PAD could have an enormous impact. Hypertension is an established risk factor for the development of atherosclerotic vascular disease including PAD. Over the past two decades, several randomized controlled trials (RCTs) have examined the efficacy of various antihypertensive agents in reducing mortality and other major adverse...
Source: The American Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Suchith Shetty, Aaqib H. Malik, Herman Feringa, Ramzi El Accaoui, Saket Girotra Source Type: research
Assessment of Cardiovascular Risk by the Combination of Clinical Risk Scores plus Platelet Expression of Fc γRIIa
Platelet expression of Fc γRIIa was quantified after myocardial infarction (MI) and we found that patients with high platelet FcγRIIa expression (>11,000/platelet) had a 4-fold greater risk of subsequent MI, stroke, and death. This analysis of the original cohort of 197 patients was designed to determine whether platelet expression of Fc γRIIa could be used in combination with clinical risk scores (GRACE [Global Registry of Acute Coronary Events] and DAPT [Dual Antiplatelet Therapy]) to refine cardiovascular risk assessment.
Source: The American Journal of Cardiology - December 6, 2019 Category: Cardiology Authors: David J. Schneider, Sean R. McMahon, Gregory L. Ehle, Sreedivya Chava, Heidi S. Taatjes-Sommer, Sean Meagher Source Type: research
Stroke Risk Based on CHA2DS2-VASc sScore in the Absence of Atrial Fibrillation
Ording et al. investigated the stroke risk in hospitalized individuals without atrial fibrillation (AF) and found it quite comparable to those with AF, especially in the setting of high (>5) CHA2DS2-VASc scores (13.3% vs. 14.6% in those without and with AF respectively).1 In fact, in men age5 without presence of AF, the risk of stoke was slightly higher than those with AF counterparts.
Source: The American Journal of Cardiology - November 27, 2019 Category: Cardiology Authors: Raj Nayyar, Dwijesh Sheth, Lovely Chhabra Source Type: research
Stroke Risk Based on CHA2DS2-VASc Score in the Absence of Atrial Fibrillation
Ording et al investigated the stroke risk in hospitalized individuals without atrial fibrillation (AF) and found it quite comparable to those with AF, especially in the setting of high (>5) CHA2DS2-VASc scores (13.3% vs 14.6% in those without and with AF respectively).1 In fact, in men age5 without presence of AF, the risk of stoke was slightly higher than those with AF counterparts.
Source: The American Journal of Cardiology - November 27, 2019 Category: Cardiology Authors: Raj Nayyar, Dwijesh Sheth, Lovely Chhabra Source Type: research
Meta-analysis Comparing Complete versus Infarct Related Artery Revascularization in Patients with ST-Elevation Myocardial Infarction and Multivessel Coronary Disease
A strategy of complete revascularization (CR) versus infarct-related artery revascularization (IRA) in patients with ST-elevation myocardial infarction (STEMI) continue to be a subject of debate. We performed an updated meta-analysis to compare the two strategies. Outcomes of interest included major adverse cardiovascular events (MACE), cardiovascular mortality, all-cause mortality, stroke, repeat revascularization, myocardial infarction, and contrast induced nephropathy. Ten randomized trials including 7,423 patients (CR=3,574 and IRA=3,849), with a follow-up of 2.0 ±0.8 years were included.
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: Mohammed Osman, Safi U. Khan, Peter D. Farjo, Noor Chima, Babikir Kheiri, Firas Zahr, Mohamad Alkhouli Source Type: research
Comparison of Long-Term Risk Adverse Outcomes In Patients with Atrial Fibrillation Having Ablation vs Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation vs. chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients undergoing AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history of diab...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research
Meta-Analysis Comparing Complete Versus Infarct-Related Artery Revascularization in Patients With ST-Elevation Myocardial Infarction and Multivessel Coronary Disease
A strategy of complete revascularization (CR) versus infarct-related artery revascularization (IRA) in patients with ST-elevation myocardial infarction (STEMI) continues to be a subject of debate. We performed an updated meta-analysis to compare the 2 strategies. Outcomes of interest included major adverse cardiovascular events (MACE), cardiovascular mortality, all-cause mortality, stroke, repeat revascularization, myocardial infarction, and contrast-induced nephropathy. Ten randomized trials including 7,423 patients (CR = 3,574 and IRA = 3,849), with a follow-up of 2.0 ± 0.8 years were included.
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: Mohammed Osman, Safi U. Khan, Peter D. Farjo, Noor Chima, Babikir Kheiri, Firas Zahr, Mohamad Alkhouli Source Type: research
Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation versus chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1,070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients who underwent AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history ...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research
Edwards SAPIEN Versus Medtronic Aortic Bioprosthesis In Women Undergoing Transcatheter Aortic Valve Implantation (From the Win-TAVI Registry)
We sought to analyze outcomes of women receiving balloon-expandable valves (BEV) or self-expanding valves (SEV) in contemporary transcatheter aortic valve implantation (TAVI). WIN TAVI (Women's INternational Transcatheter Aortic Valve Implantation) is the first all-female TAVI registry to study the safety and performance of TAVI in women. We compared women treated with BEV (n=408, 46.9%) versus those treated with SEV (n = 461, 53.1%). The primary efficacy endpoint was the (VARC-2) composite of 1-year all-cause death, stroke, myocardial infarction, hospitalization for valve-related symptoms or heart failure or valve-related dysfunction.
Source: The American Journal of Cardiology - November 7, 2019 Category: Cardiology Authors: Cristina Giannini, Anna Sonia Petronio, Julinda Mehilli, Samantha Sartori, Jaya Chandrasekhar, Michela Faggioni, Thierry Lef èvre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas M. Van Mieghem, Emanu Source Type: research
Meta-Analysis Comparing Results of Transcatheter versus Surgical Aortic-Valve Replacement in Patients with Severe Aortic Stenosis
Transcatheter aortic-valve replacement (TAVR) has emerged as a promising strategy for treating patients with severe aortic stenosis. We aimed to compare TAVR with surgical aortic-valve replacement (SAVR) and determine the performance of TAVR over time and within several subgroups. We included 8 randomized trials comparing TAVR vs. SAVR. Compared with SAVR, TAVR was associated with a lower rate of all-cause mortality or disabling stroke at 30-day (odds ratio [OR], 0.72; P=0.004), 1-year (OR, 0.83; P=0.01) and 2-year (OR, 0.86; P=0.02), but not at long-term follow-up (rate ratio [RR], 1.02 [CI, 0.92 to 1.13]; P=0.67).
Source: The American Journal of Cardiology - November 6, 2019 Category: Cardiology Authors: Xinlin Zhang, Tingyu Wang, Rongfang Lan, Qing Dai, Lina Kang, Lian Wang, Yong Wang, Wei Xu, Biao Xu Source Type: research
Incidence and Outcomes of Acute Ischemic Stroke Following Percutaneous Coronary Interventions in Men Versus Women
Comparative data on the incidence and outcomes of stroke after percutaneous coronary interventions (PCI) between men and women are limited. We identified hospitalizations for PCI in the National-Inpatient-Sample between January 1st 2003 and December 31st 2016. We compared the incidence of post-PCI stroke and in-hospital complications, mortality, and cost of post-PCI strokes between men and women. Among 8,753,574 weighted hospitalizations for PCI, 49,097 (0.56%) were complicated with ischemic stroke.
Source: The American Journal of Cardiology - November 6, 2019 Category: Cardiology Authors: Mohamad Alkhouli, Fahad Alqahtani, Mohamed Farouk Elsisy, Akram Kawsara, Mirvat Alasnag Source Type: research
Detecting Atrial Fibrillation in Patients with an Embolic Stroke of Undetermined Source (From the DAF-ESUS registry)
Atrial fibrillation (AF) causes a substantial proportion of embolic strokes of undetermided source (ESUS). Effective detection of subclinical AF (SCAF) has important therapeutic implications. We conducted a prospective study to determine the prevalence of SCAF in patients with ESUS through of a 21-day Holter monitoring. In an early-monitoring group, Holter was initiated immediately after hospital discharge. The results were compared with a previous cohort of patients in whom the Holter was initiated at least one week after hospital discharge (late-monitoring group).
Source: The American Journal of Cardiology - November 5, 2019 Category: Cardiology Authors: Jos é Manuel Rubio Campal, M Araceli García Torres, Pepa Sánchez Borque, Inmaculada Navas Vinagre, Ivana Zamarbide Capdepón, Ángel Miracle Blanco, Loreto Bravo Calero, Rafael Sáez Pinel, José Tuñón Fernández, José María Serratosa Fernández Source Type: research
