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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Relation of Serum Uric Acid and Cardiovascular Events in Young Adults Aged 20-49 Years
In this study, we aimed to identify the association of medication na ïve SUA with incident CVD including myocardial infarction (MI), stroke, heart failure (HF) and atrial fibrillation (AF) using a nationwide epidemiological database. We analyzed 353,613 participants aged 20–49 years, who were not taking UA lowering medications, and had no prevalent history of card iovascular disease (CVD) using a nationwide health claims database collected in the JMDC Claims Database between 2005 and 2018.
Source: The American Journal of Cardiology - June 14, 2021 Category: Cardiology Authors: Hikari Seki, Hidehiro Kaneko, Hiroyuki Morita, Hidetaka Itoh, Kojiro Morita, Satoshi Matsuoka, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Yuichiro Yano, Sunao Nakamura, Koichi Node, Hideo Yasunaga, I Source Type: research
Effect of Lipoprotein (a) Levels on Long-term Cardiovascular Outcomes in Patients with Myocardial Infarction with Nonobstructive Coronary Arteries
The association between elevated lipoprotein(a) [Lp(a)] and poor outcomes in coronary artery disease (CAD) has been addressed for decades. However, little is known about the prognostic value of Lp(a) in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA). A total of 1179 patients with MINOCA were enrolled and divided into low, medium, and high Lp(a) groups based on the cut-off value of 10 and 30mg/dL. The primary endpoint was major adverse cardiovascular events (MACE), a composite of all-cause death, nonfatal MI, nonfatal stroke, revascularization, and hospitalization for unstable angina or heart failure.
Source: The American Journal of Cardiology - June 12, 2021 Category: Cardiology Authors: Side Gao, Wenjian Ma, Sizhuang Huang, Xuze Lin, Mengyue Yu Source Type: research
MAUDE Database Analysis of Post-Approval Outcomes following Left Atrial Appendage Closure with the Watchman Device
The objective of this study was to determine the frequency and timing of adverse events associated with Watchman LAAC device implants performed after FDA approval. Adverse events associated with Watchman LAAC implants performed between March 2015 and March 2019 were identified through a search of the FDA Manufacturer and User Facility Device Experience (MAUDE) database.
Source: The American Journal of Cardiology - June 8, 2021 Category: Cardiology Authors: Pablo A. Ledesma, Uwajachukwumma A. Uzomah, Xuejing Yu, Ayman Shaqdan, Pegah Khaloo, Jennifer Galvin, Moussa Mansour, Leon M. Ptaszek, Jeremy N. Ruskin Source Type: research
Triglyceride –Rich Lipoproteins, Apolipoproteins, and Atherosclerotic Cardiovascular Events Among Patients with Diabetes Mellitus and End–Stage Renal Disease on Hemodialysis
Hypertriglyceridemia may be implicated in the high atherosclerotic cardiovascular disease (ASCVD) risk experienced by patients with end –stage renal disease (ESRD). In this post–hoc analysis of the “Die Deutsche Diabetes Dialyse Studie (4D)” clinical trial, we examined incident ASCVD events, defined as myocardial infarction, ischemic stroke, or a coronary revascularization procedure, among 1255 participants with type 2 diabe tes and ESRD treated with hemodialysis. Cox–regression methods were used to evaluate the association of triglycerides, very–low density lipoprotein cholesterol (VLDL–C), and apolipoprotei...
Source: The American Journal of Cardiology - June 6, 2021 Category: Cardiology Authors: Julio A. Lamprea –Montealegre, Ronit Katz, Hubert Scharnagl, Günther Silbernagel, Winfried März, Christiane Drechsler, Cristoph Wanner, Ian H. de Boer Source Type: research
Meta-analysis of the Safety and Efficacy of the Sentinel Cerebral Protection System in Transcatheter Aortic Valve Implantation
Despite recent advances in transcatheter aortic valve implantation (TAVI), cerebrovascular events (CVE) remain one of the most feared complications of the procedure adversely affecting morbidity and mortality. Several imaging studies showed most of the CVEs after TAVI have a probable embolic etiology from debris during the procedure. It is also hypothesized that patients can develop long-term neurocognitive dysfunction following TAVI due to these emboli.1 As TAVI expands to younger and lower risk patients, the prevention of stroke plays an increasingly important role.
Source: The American Journal of Cardiology - May 29, 2021 Category: Cardiology Authors: Yasser Radwan, Abdullah Al-abcha, Mohammad Fahad Salam, Si Yuan Khor, Rohan Madhu Prasad, Ahmed Elshafie, George Abela Source Type: research
Hemodynamic Profiles of Shock in Patients with COVID-19
Patients with serious COVID infections develop shock frequently. To characterize the hemodynamic profile of this cohort, 156 patients with COVID pneumonia and shock requiring vasopressors had interpretable echocardiography with measurement of ejection fraction (EF) by Simpson's rule and stroke volume (SV) by Doppler. RV systolic pressure (RVSP) was estimated from the tricuspid regurgitation peak velocity. Patients were divided into groups with low or preserved EF (EFL or EFP, cutoff ≤45%), and low or normal cardiac index (CIL or CIN, cutoff ≤2.2 L/min/m2).
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Steven M Hollenberg, Lucy Safi, Joseph E Parrillo, Matthew Fata, Brent Klinkhammer, Noha Gayed, Taya Glotzer, Ronaldo C. Go, Elli Gourna-Paleoudis, David Landers, Sameer Jamal, Neel Shah, Roshan Shah, Jana Tancredi, Zoltan G Turi Source Type: research
Prevalence, Incidence and Prognostic Implications of Left Bundle Branch Block in Patients with Chronic Coronary Syndromes (From the CLARIFY Registry)
Left Bundle Branch Block (LBBB) is a frequently encountered electrical abnormality in patients with chronic (more than 3 months after myocardial infarction, or evidence of coronary artery disease with ischemia) coronary syndromes (CCS), but its prognostic significance remains unclear. We aimed to describe the prevalence, incidence and five-year outcomes of LBBB in outpatients with CCS using the CLARIFY registry. Main outcome was a composite of CV death, MI or stroke. Secondary outcomes included all cause death, hospitalization for heart failure (HF) and permanent pacemaker implantation.
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Arthur Darmon, Gregory Ducrocq, Yedid Elbez, Batric Popovic, Emmanuel Sorbets, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg, CLARIFY Investigators Source Type: research
Aspirin for Primary Prevention of Cardiovascular Disease in the 21st Century: A Review of the Evidence
Aspirin (ASA) is the most commonly prescribed antiplatelet agent. Although the evidence for efficacy of aspirin for secondary prevention of ischemic events in patients with established cardiovascular disease is strong, its role in primary prevention has been subject of controversies over the past decades. In fact, historical trials have shown only modest benefit in terms of reduction of ischemic events, mostly myocardial infarction and to a lesser extent stroke, and only at the expense of an increased risk of bleeding.
Source: The American Journal of Cardiology - March 9, 2021 Category: Cardiology Authors: Dominick J Angiolillo, Davide Capodanno Source Type: research
The Future of Aspirin Therapy in Cardiovascular Disease
Much has been written about the demise of aspirin (ASA) but reports of its death are premature. The drug remains one of the most widely prescribed by physicians worldwide. It is cheap, familiar, and effective for a variety of uses, including in patients with acute or prior myocardial infarction, ischemic stroke, peripheral artery disease, and percutaneous or surgical revascularization procedures, as well as for use for pain and fever relief. Beyond physician prescription or recommendation, over the counter use of ASA is common, including for primary cardiovascular prevention, though this decision really should involve a di...
Source: The American Journal of Cardiology - March 9, 2021 Category: Cardiology Authors: Deepak L. Bhatt, Charles V. Pollack Source Type: research
Relation of Atrial Fibrillation to Cognitive Decline (from the REasons for Geographic and Racial Differences in Stroke REGARDS Study)
The association of atrial fibrillation (AF) with cognitive function remains unclear, especially among racially/geographically diverse populations. This analysis included 25,980 black and white adults, aged 48+, from the national REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, free from cognitive impairment and stroke at baseline. Baseline AF was identified by self-reported medical history or electrocardiogram (ECG). Cognitive testing was conducted yearly with the Six Item Screener (SIS) to define impairment and at 2-year intervals to assess decline on: animal naming and letter fluency, Montreal Co...
Source: The American Journal of Cardiology - March 5, 2021 Category: Cardiology Authors: Margie J. Bailey, Elsayed Z. Soliman, Leslie A. McClure, George Howard, Virginia J. Howard, Suzanne E. Judd, Fred Unverzagt, Virginia Wadley, Bonnie C. Sachs, Timothy Hughes Source Type: research
Thoracic Aortic Calcium For The Prediction Of Stroke Mortality (From The Coronary Artery Calcium Consortium)
Thoracic aortic calcium(TAC) is an important marker of extra-coronary atherosclerosis with established predictive value for all-cause mortality. We sought to explore the predictive value of TAC for stroke mortality, independent of the more established coronary artery calcium(CAC) score. The CAC Consortium is a retrospectively assembled database of 66,636 patients aged ≥18 years with no prior history of cardiovascular disease, baseline CAC scans for risk stratification, and follow-up for 12±4 years.
Source: The American Journal of Cardiology - March 2, 2021 Category: Cardiology Authors: Olufunmilayo H. Obisesan, Albert D. Osei, Daniel Berman, Zeina A. Dardari, S.M Iftekhar Uddin, Omar Dzaye, Olusola A. Orimoloye, Matthew J. Budoff, Michael D Miedema, John Rumberger, Mohammadhassan Mirbolouk, Ellen Boakye, Michelle C. Johansen, Alan Rozan Source Type: research
Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients after Percutaneous Mitral Valve Repair
Transcatheter mitral valve repair (TMVR) using the MitraClip system (Abbott Vascular, Abbott Park, Illinois) has emerged as an effective treatment option for surgical high-risk patients with severe functional mitral regurgitation (MR) and chronic heart failure (CHF)1-9. However, several predictors of worse prognosis in patients treated by TMVR have been identified, e.g. high levels of NT-proBNP, New York Heart Association (NYHA) functional class IV prior to TMVR and a severely impaired left and right heart function5,8,10-13.
Source: The American Journal of Cardiology - February 25, 2021 Category: Cardiology Authors: Rico Osteresch, Kathrin Diehl, Patrick Dierks, Johannes Schmucker, Azza Ben Ammar, Andreas Fach, Harald Langer, Ingo Eitel, Rainer Hambrecht, Harm Wienbergen Source Type: research
Blood Coagulation Changes With or Without Direct Oral Anticoagulant Therapy Following Transcatheter Aortic Valve Implantation
Thromboembolic events remain clinically unresolved after transcatheter aortic valve implantation (TAVI).1, 2 The mechanism of thromboembolic events after TAVI is multifactorial. The activation of the coagulation pathway induced by valve implantation may stimulate thrombus formation. 1, 3 However, blood coagulation change following TAVI was not fully investigated. The incidence of preexisting atrial fibrillation in patients with severe aortic valve stenosis is as high as 20% –30%.4 Although the use of direct oral anticoagulant (DOAC) for stroke prevention has increased, DOAC use to reduce thrombosis associated with TAVI r...
Source: The American Journal of Cardiology - February 19, 2021 Category: Cardiology Authors: Taiga Katayama, Naoyuki Yokoyama, Yusuke Watanabe, Shinji Takahashi, Hirofumi Hioki, Kazuo Kawasugi, Ken Kozuma Source Type: research
Usefulness of Rhythm Monitoring Following Acute Ischemic Stroke
Atrial fibrillation (AF) is a well-recognized risk factor for ischemic stroke, and AF-related strokes are typically severe.1,2 Recognizing AF as the underlying mechanism of stroke is important, as oral anticoagulation substantially reduces risk of recurrent stroke.3 –5 AF is frequently subclinical, however, and detected only after extended rhythm monitoring.6–8 As a result, current guidelines provide a Class IIa recommendation (moderate strength and good quality evidence) for extended rhythm monitoring (“∼ 30 days”) within six months following cryptog enic stroke (i.e., strokes with no apparent mechanism).
Source: The American Journal of Cardiology - February 19, 2021 Category: Cardiology Authors: Shaan Khurshid, Xinye Li, Jeffrey M. Ashburner, Ana T. Trisini Lipsanopoulos, Priscilla R. Lee, Aimee K. Lin, Darae Ko, Patrick T. Ellinor, Lee H. Schwamm, Emelia J. Benjamin, Steven J. Atlas, Daniel E. Singer, Christopher D. Anderson, Ludovic Trinquart, Source Type: research
Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
One of the most feared complications of transcatheter aortic valve implantation (TAVI) is stroke, with increased mortality and disability observed in patients suffering a stroke after TAVI. There has been no significant decline in stroke rates seen over the last 5 years; attention has therefore been given to strategies for cerebral embolic protection. With the emergence of new randomized trial data, we sought to perform an updated systematic review and meta-analysis to examine the effect of cerebral embolic protection during TAVI both on clinical outcomes and on neuroimaging parameters.
Source: The American Journal of Cardiology - February 4, 2021 Category: Cardiology Authors: Dr Yousif Ahmad, James P. Howard Source Type: research
