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Source: Journal of Hypertension

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Total 283 results found since Jan 2013.

Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat
Conclusion: The dual angiotensin II type 1 receptor/neutroendopeptidase inhibition significantly increased atrial natriuretic peptide level and reduced BP. Complete prevention of stroke was achieved in this model. The ability of sacubitril/valsartan to reduce organ damage progression was superior to that of valsartan alone. ARNi may represent a highly effective therapeutic agent to protect from target organ damage development in hypertension.
Source: Journal of Hypertension - September 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Intensive blood pressure control may not be safe in subacute ischemic stroke by intracranial atherosclerosis: a result of randomized trial
Objective: Current guideline recommends intensive blood pressure (BP) control in hypertensive patients, but the appropriate target BP level after ischemic stroke due to intracranial atherosclerotic stenosis remains uncertain. Methods: In this randomized, single-blinded trial, patients with symptomatic internal carotid or middle cerebral artery steno-occlusion (>50%) within 7–42 days after index stroke received intensive (target SBP 
Source: Journal of Hypertension - September 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Effects of blood pressure-lowering treatment on cardiovascular outcomes and mortality: 14 – effects of different classes of antihypertensive drugs in older and younger patients overview and meta-analysis
Conclusion: Most BP-lowering classes are equally effective in preventing risk of fatal and nonfatal cardiovascular events both in older and younger patients, whereas beta-blockers, though being equally effective as the other agents in patients younger than 65, loose some of their effectiveness at an older age.
Source: Journal of Hypertension - June 28, 2018 Category: Cardiology Tags: Meta-Analyses Source Type: research

Three-dimensional echocardiographic ventricular mass/end-diastolic volume ratio in native hypertensive patients: relation between stroke volume and geometry
Background: Elevated left ventricular (LV) mass/end-diastolic volume ratio (LVM/EDV) has been associated with higher evidence of myocardial fibrosis and dysfunction in hypertensive patients by cardiac magnetic resonance, a technique with limited availability. Objectives: We investigated the ability of three-dimensional (3D) echocardiography in identifying a phenotype of LV concentric geometry according to LVM/EDV ratio, possibly detecting early myocardial damage in native-hypertensive patients. Methods: One hundred and twenty-eight native-hypertensive patients underwent 2D and 3D-echocardiography. The population wa...
Source: Journal of Hypertension - June 28, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Do patients actually do what we ask: patient fidelity and persistence to the Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups blood pressure self-management intervention
Conclusion: Most patients randomized to self-management completed training; however, 36% of these had dropped out by 12 months. Self-monitoring was largely undertaken properly and accurately recorded. Fidelity with self-management was associated with lower achieved SBP. Successful implementation of self-management into daily practice requires careful training and should be accompanied by monitoring of fidelity.
Source: Journal of Hypertension - June 28, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity part A mechanisms of obesity induced hypertension, diabetes and dyslipidemia and practice guidelines for treatment
Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key ro...
Source: Journal of Hypertension - May 31, 2018 Category: Cardiology Tags: Consensus Documents Source Type: research

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity part B obesity-induced cardiovascular disease, early prevention strategies and future research directions
Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications.
Source: Journal of Hypertension - May 31, 2018 Category: Cardiology Tags: Consensus Documents Source Type: research

Blood pressure in acute ischemic stroke: challenges in trial interpretation and clinical management position of the ESH Working Group on Hypertension and the Brain
Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Importantly, the observed relationship between BP and stroke outcome may or may not be causally related. Higher baseline BPs in focal cerebral ischemia may indicate preexisting hypertension, but may also be an effect of both nonspecific and stroke-related factors. Although antihypertensive therapy effectively redu...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: Consensus Documents Source Type: research

Blood pressure-lowering drugs and secondary prevention of cardiovascular disease: systematic review and meta-analysis
Conclusions: Although only ACEIs have evidences showing its effect in reducing cardiovascular events and all secondary outcomes, head-to-head comparisons did not provide strong evidence in difference in the effects between these blood pressure-lowering drugs.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: Reviews Source Type: research

Target home morning SBP be below 125 mmHg in type 2 diabetes patients
Background: It is not established to what extent self-monitoring of home BP be lowered in patients with type 2 diabetes. We tested the hypothesis that the appropriate home morning SBP cutoff value is 125 mmHg in our stratification of cardiovascular risk in type 2 diabetes. Method: Clinic and home BP monitoring were performed in 4308 individuals (1057 people with diabetes and 3251, nondiabetes), and we tested two cutoff values of home morning SBP (MSBP): 135 and 125 mmHg. Multivariable Cox regression analyses adjusting for age, sex, body mass index, history of cardiovascular events, presence of chronic kidney disea...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement Source Type: research

High SBP trajectories are associated with risk of all-cause death in general Chinese population
Conclusion: High SBP trajectories are independent risk factors for all-cause death. Our findings suggest increasing SBP trajectories within the currently designated ‘normal’ range may still increase risk of all-cause death.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Impact of obstructive sleep apnea on cardiac organ damage in patients with acute ischemic stroke
Background and purpose: Both obstructive sleep apnea (OSA) and cardiac organ damage have a crucial role in acute ischemic stroke. Our aim is to explore the relationship between OSA and cardiac organ damage in acute stroke patients. Methods: A total of 130 consecutive patients with acute ischemic stroke were enrolled. Patients underwent full multichannel 24-h polysomnography for evaluation of OSA and echocardiography to evaluate left ventricle (LV) mass index (LV mass/BSA, LV mass/height2.7), thickness of interventricular septum (IVS) and posterior wall (LVPW), LV ejection fraction and left atrium enlargement. Informat...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats
Conclusion: The current study shows for the first time that in hypertension the number of TF-positive megakaryocytes increases thus releasing in the circulation more platelets carrying a functionally active TF. AngII stimulates platelets to express TF.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Early antihypertensive treatment and clinical outcomes in acute ischemic stroke: subgroup analysis by baseline blood pressure
Background: We studied the effect of early antihypertensive treatment on death, major disability, and vascular events among patients with acute ischemic stroke according to their baseline SBP. Methods: We randomly assigned 4071 acute ischemic stroke patients with SBP between 140 and less than 220 mmHg to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization. A composite primary outcome of death and major disability and secondary outcomes were compared between treatment and control stratified by baseline SBP levels of less than 160, 160–179, and at least 180 ...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

SPRINT in context: meta-analysis of trials with baseline normotension and low levels of previous cardiovascular disease
Conclusion: SPRINT results are not representative for trials with baseline normotension and low levels of previous cardiovascular disease. Antihypertensive treatment does not protect against death or major cardiovascular events in this setting.
Source: Journal of Hypertension - March 27, 2018 Category: Cardiology Tags: Reviews Source Type: research