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Source: Journal of Hypertension
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Total 283 results found since Jan 2013.
Dynamic resistant hypertension patterns as predictors of cardiovascular morbidity: a 4-year prospective study
Conclusion:In treated hypertensive patients, among prospective RHT dynamic patterns, persistent RHT is frequent and independently associated with adverse cardiovascular prognosis.
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Resistant hypertension Source Type: research
Association of cognitive dysfunction with cardiovascular disease events in elderly hypertensive patients
This study assesses whether presence of cognitive dysfunction can be a marker associated with the development of cardiovascular disease (CVD) events independent of ambulatory blood pressure (BP) or other indices of target organ damage (TOD) in elderly hypertensive patients.
Methods:We recruited 585 hypertensive patients (mean age, 73 years; 41% men) who were ambulatory, lived independently, and were without clinically overt dementia. Cognitive function was assessed by Mini-Mental State Examination (MMSE) at baseline, and CVD events (coronary artery disease, stroke, congestive heart failure, and sudden death) were prospecti...
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Cognition Source Type: research
Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death
Conclusion:The NEDD4L salt sensitivity-associated genotype was associated with higher blood pressure, which may translate into increased risk for CVD morbidity and mortality. Interestingly, there was no association with stroke suggesting that the association is partially blood pressure independent.
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Genetic aspects Source Type: research
Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project
Conclusion:Orthostatic hypotension has a dual role in cardiovascular events among hypertensive patients: SBP fall indicates higher risk of stroke, whereas DBP fall confers higher risk of MI.
Source: Journal of Hypertension - December 18, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Orthostatic hypotension Source Type: research
Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project
Conclusion: Orthostatic hypotension has a dual role in cardiovascular events among hypertensive patients: SBP fall indicates higher risk of stroke, whereas DBP fall confers higher risk of MI.
Source: Journal of Hypertension - December 17, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Orthostatic hypotension Source Type: research
Long-term alcohol consumption is an independent risk factor of hypertension development in northern China: evidence from Kailuan study
Objective:The purpose of the present study was to determine the impact of alcohol consumption on the incidence of hypertension.
Methods:A total of 32 389 male coal mine workers from Kailuan Coal Group in northern China (Kailuan study), free of hypertension, myocardial infarction, stroke, transient ischemia attack and cancer, were followed up every 2 years for 4 years. The average alcohol intake during the past year was reported as baseline.
Results:During 4 years of follow-up, 9151 out of 32 389 workers developed hypertension categorically. At the end of the follow-up, the cumulative incidence of hypertension in relati...
Source: Journal of Hypertension - November 13, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research
African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia
Objectives:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored.
Methods:We compared prevalence of brain infarcts, and severe white matter hyperintensities (WMHs) on cerebral MRI, in a community-based sample of men and women aged 58–86 of African Caribbean (214) and European (605) descent, in London, UK. Resting, central and ambulatory blood pressure (BP) were measured; diabetes was assessed by blood testing and questionnaire.
Results:Mean age was 70. Multipl...
Source: Journal of Hypertension - November 13, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Brain Source Type: research
Protective effect of valsartan for stroke in Japanese subjects: an analysis of Jikei Heart Study: Retraction
No abstract available
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: Retractions Source Type: research
Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life
Objectives:We assessed whether hypertension in pregnancy is associated with elevated C-reactive protein (CRP) levels in later life, possibly reflecting an increased risk of cardiovascular disease (CVD).
Background:Elevated CRP levels have been associated with hypertension in pregnancy and with CVD.
Methods:We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Participants were categorized as nulliparous women (n = 219), women with a history of normotensive pregnancies (n = 1839), or women with a history of a hypertensive pregnancy (n = 405). Using multiple linear regression ...
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Pregnancy Source Type: research
The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity
Conclusion: Despite substantial increases in CO and SV, we did not observe any significant change in BP during high sodium intake, neither in morbid obese patients nor in lean individuals.
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats
Background and aim:Iron is the most abundant metal in mammalian cells, and plays a pivotal role in many metabolic processes. Dysregulated iron homeostasis is involved in the cause of a number of pathological processes including renal diseases.
Methods and results:Longitudinal MRI scans of salt-loaded spontaneously hypertensive stroke-prone rats (SHRSP), an animal model that spontaneously develops hypertensive nephropathy, showed a decrease in renal and hepatic T2∗ SI (a sign of iron accumulation) of, respectively, 42.3 ± 2.5% (P
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
The unappreciated importance of blood pressure in recent and older atrial fibrillation trials
Atrial fibrillation and arterial hypertension represent two common clinical conditions that frequently coexist, especially in older individuals, and are associated with increased risk of stroke. Antihypertensive therapy reduces the risk of stroke by approximately 40%. It has been observed that stroke rates were reduced by 10% for every 2-mmHg reduction of blood pressure. Antithrombotic therapy reduces significantly the risk for ischemic stroke in patients with atrial fibrillation at the expense of increased risk of intracranial bleeding. The importance of hypertension in patients with atrial fibrillation is recognized by i...
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: Review Source Type: research
Association of central pulse pressure with contrast-induced nephropathy and clinical outcomes in patients undergoing coronary intervention
Conclusion:Elevated baseline central PP was associated with an increased risk of CIN and future cardiovascular events in patients with PCI. Further clinical study may be indicated to determine whether pharmacological modulation on baseline central PP could prevent CIN and future MACE after PCI.
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement Source Type: research
Hypertensive renal disease: susceptibility and resistance in inbred hypertensive rat lines
Background:Spontaneously hypertensive rat (SHR) lines differ in their susceptibility to hypertensive end-organ disease and may provide an informative model of genetic risk of disease. Lines derived from the original SHR-B and SHR-C clades are highly resistant to hypertensive end-organ disease, whereas lines derived from the SHR-A clade were selected for stroke susceptibility and experience hypertensive renal disease.
Method:Here we characterize the temporal development of progressive renal injury in SHR-A3 animals consuming 0.3% sodium in the diet and drinking water. SHR-A3 rats demonstrate albuminuria, glomerular damage, ...
Source: Journal of Hypertension - September 11, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
Systolic left ventricular function according to left ventricular concentricity and dilatation in hypertensive patients: the Losartan Intervention For Endpoint reduction in hypertension study
Background:Left ventricular hypertrophy [LVH, high left ventricular mass (LVM)] is traditionally classified as concentric or eccentric based on left ventricular relative wall thickness. We evaluated left ventricular systolic function in a new four-group LVH classification based on left ventricular dilatation [high left ventricular end-diastolic volume (EDV) index and concentricity (LVM/EDV(2/3))] in hypertensive patients.
Methods and results:Nine hundred thirty-nine participants in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) echocardiography substudy had measurable LVM at enrolment. Patients wit...
Source: Journal of Hypertension - September 11, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research
