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Source: Journal of Hypertension
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Total 283 results found since Jan 2013.
Protective effects of antihypertensive treatment in patients aged 85 years or older
Conclusion: Adherence with antihypertensive drug therapy reduced the risk of cardiovascular morbidity in patients aged 85 years or more, the benefit including heart failure and stroke, although not MI, and extending to all-cause death.
Source: Journal of Hypertension - June 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Elderly Source Type: research
Should elevated blood pressure be lowered in the acute phase of ischaemic stroke?
No abstract available
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: Editorial Commentaries Source Type: research
Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial
Objective: The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment.
Methods: We randomly assigned 4071 acute ischemic stroke patients with elevated SBP to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization. The primary outcome was a combination of death and major disability, and secondary outcomes included the modified Rankin score, recurrent st...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research
Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study
This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale.
Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both pri...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research
MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension
Conclusion: In patients with hypertension, progression of periventricular WMH over 4 years is associated with cognitive decline, whereas we could not show an association between baseline periventricular WMH and cognitive decline. These results emphasize the importance of preventing progression of WMH in hypertensive patients.
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research
Physical activity and cognitive function among older adults with hypertension
Objective: We evaluated the specific association between physical activity and cognitive function among a national sample of the broader US adult population with evidence of systemic hypertension.
Methods: Data from the 1999–2002 National Health and Nutrition Examination Survey were used to identify 1554 older adults, aged 60–85 years, with evidence of hypertension. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function tasks of pairing and free recall among participants. Participants were asked open-ended questions about participation in leisure-time physical activity over the past 30 days. F...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research
Folic acid therapy reduces the risk of mortality associated with heavy proteinuria among hypertensive patients
Objective: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial.
Methods: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n = 10 348), or 10-mg enalapril alone (n = 10 354). All-cause mortality, a pr...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
Side effects and tolerability of combination blood pressure lowering according to blood pressure levels: an analysis of the PROGRESS and ADVANCE trials
Conclusion: Compared with those with baseline SBP 140–159 mmHg, side effects of dual combination BPL are essentially the same for people with SBP 130–139 mmHg and only modestly increased among patients with SBP 120–129 mmHg. During long-term therapy, side effects sufficient to stop treatment that are treatment related (i.e. occur in excess of rates seen with placebo) occur at less than 0.5%/year in patients with baseline SBP 120–139 mmHg. These results have important implications in assessing the likely balance of benefits and side effects of BPL with combination therapy among those with SBP 120–139 mmHg.
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
New oral anticoagulants and prevention of thromboembolic events in patients with hypertension and atrial fibrillation: an appraisal
Arterial hypertension (HTN) and atrial fibrillation often coexist and the combination of these two conditions carries an increased risk of stroke. HTN is one of the most important risk factors included in the scores for stoke prediction in atrial fibrillation used to assess the need of anticoagulation, and HTN has also been strictly related to bleeding complications of antithrombotic therapy. Antithrombotic drugs options include vitamin K antagonists, or new oral anticoagulants, recently approved for stroke prevention in nonvalvular atrial fibrillation. More favorable new oral anticoagulant efficacy and safety, compared wi...
Source: Journal of Hypertension - March 2, 2017 Category: Cardiology Tags: Reviews Source Type: research
Association between MRI-derived hepatic fat fraction and blood pressure in participants without history of cardiovascular disease
Objectives: We assessed whether liver fat content, as determined by MRI, correlates with blood pressure (BP), a major vascular risk factor, in individuals from the general population without history of stroke and coronary or peripheral artery disease.
Methods: Cross-sectional data from 384 participants (161 women; aged 39–73 years) of a MRI substudy of the KORA FF4 survey were used. Hepatic fat fraction (HFF) was measured in the left and right lobe of the liver using single voxel multiecho 1H-spectroscopy and at the level of the portal vein using a multiecho Dixon-sequence. Associations of HFF with SBP and DBP as well a...
Source: Journal of Hypertension - March 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research
Prestroke treatment with beta-blockers for hypertension is not associated with severity and poor outcome in patients with ischemic stroke: data from a national stroke registry
Background: Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypertensive patients hospitalized with acute ischemic stroke.
Methods: All 3915 patients with ischemic stroke, treated prestroke for hypertension and registered in the National Acute Stroke ISraeli, were included. Treatment for hypertension was classified by medication type (beta-blockers, diuretics, calcium ant...
Source: Journal of Hypertension - March 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Blood pressure treatment levels and choice of antihypertensive agent in people with diabetes mellitus: an overview of systematic reviews
Conclusion: The available evidence supports treatment in people with type 2 diabetes and SBP more than 140 mmHg, using any of the major antihypertensive drug classes.
Source: Journal of Hypertension - January 31, 2017 Category: Cardiology Tags: Reviews Source Type: research
Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3
Conclusion: This study has identified distinct intervals on RNO3-containing genes that may be important for blood pressure regulation and renal pathology during salt challenge.
Source: Journal of Hypertension - December 23, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Genetic aspects Source Type: research
Visit-to-visit blood pressure variability is a risk factor for all-cause mortality and cardiovascular disease: a systematic review and meta-analysis
Conclusion: In summary, among the wide heterogenetic population, modest associations between VVV of SBP and all-cause mortality, CVD incidence, CVD mortality, CHD incidence, and stroke incidence were found. Findings of the current study suggested that standardized approaches of monitoring VVV in the high-risk population, including patients with cardiac infarction, diabetes, stroke, and patients with chronic kidney disease or in dialysis, are necessary in designing a prospective clinical study on the association of VVV and patients’ prognosis.
Source: Journal of Hypertension - December 1, 2016 Category: Cardiology Tags: Reviews Source Type: research
Cost-utility analysis of physician–pharmacist collaborative intervention for treating hypertension compared with usual care
Conclusion: Team-based care such as a physician–pharmacist collaboration appears to be a cost-effective strategy for treating hypertension. The intervention is most cost-effective for high-risk patients.
Source: Journal of Hypertension - December 1, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
