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Source: Journal of Hypertension
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Total 283 results found since Jan 2013.
The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss
Background:Genetic background partly determines the efficacy of interventions to lower blood pressure (BP). The CYP4F2 and CYP4A11 enzymes are renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthases that regulate BP. Gene variants of CYP4F2 and CYP4A11 associate with hypertension and stroke. We showed that a gene variant of CYP4F2 but not CYP4A11 was associated with increased 20-HETE excretion and BP.
Aim:To compare BP and 20-HETE responses in carriers of the CYP4F2 1347G/A polymorphism and controls CYP4F2-GG (wildtype), during weight loss.
Methods:Volunteers genotyped as CYP4F2GA/AA (n = 26) and controls genotyped a...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research
Impact of telmisartan on cardiovascular outcome in hypertensive patients at high risk: a Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease subanalysis
Background:In the Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease, all patients were at high cardiovascular risk, and a substantial proportion were hypertensive. We performed a post-hoc analysis to explore the hypothesis that telmisartan has a differential action in hypertensive vs. nonhypertensive patients.
Methods:The primary four-fold endpoint (composite of cardiovascular death, myocardial infarction (MI), stroke, or hospitalization for heart failure), the secondary three-fold endpoint (cardiovascular death, MI, and stroke), the individual components, new onset of left vent...
Source: Journal of Hypertension - May 1, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Hypertension, alcohol drinking and stroke incidence: a population-based prospective cohort study among inner Mongolians in China
Conclusion:These findings suggest that hypertension is an independent risk factor of stroke in Inner Mongolians. Drinkers with hypertension seem to be more susceptible to stroke; larger-sample prospective cohort studies are still required to examine the cumulative effect of drinking and hypertension on stroke incidence.
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research
Large artery stiffness and carotid flow pulsatility in stroke survivors
Objective:Aortic stiffness is increased in lacunar stroke. The precise mechanism linking aortic stiffness to symptomatic lacunar stroke is not well understood. The aim of this study was to compare the effects of aortic stiffness, carotid stiffness, central blood pressure, and cerebrovascular resistance on carotid flow pulsatility according to stroke subtype.
Methods:Two hundred and one consecutive patients were examined 13 months after hospitalization for their first-ever ischemic stroke. The stroke subtype was classified using the Causative Classification of Stroke System. Carotid–femoral pulse wave velocity (PWV) was u...
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research
Postprandial hypotension as a risk marker for asymptomatic lacunar infarction
Objective:Increasing blood pressure (BP) variability is reported to be a cardiovascular risk factor. However, the clinical implications of postprandial hypotension (PHYPO), a commonly observed BP variability in elderly persons, are poorly understood. Here, we investigated the possible associations between postprandial BP decline and asymptomatic cerebral damage in community residents.
Methods:Study participants consisted of 1308 general community residents (65 ± 9 years old). Postprandial BP change was calculated from SBP measured just before and 30 min after lunch. PHYPO was defined as a decline in SBP of more than...
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research
Do other cardiovascular risk factors influence the impact of age on the association between blood pressure and mortality? The MORGAM Project
Conclusion:Age-related shifts to the superiority of SBP exist for stroke mortality and all-cause mortality, and for stroke mortality was this shift influenced by other cardiovascular risk factors.
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiovascular risk Source Type: research
Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals
Method:Two thousand and fifty-nine healthy individuals aged 41, 51, 61 and 71 years examined in 1993, were divided in age, SCORE and Framingham risk score (FRS) groups. Subclinical vascular damage (SVD) was defined as carotid-femoral pulse wave velocity (cfPWV) at least 12 m/s, carotid atherosclerotic plaques or albuminuria defined as urine albumin/creatinine ratio at least 90th percentile of 0.73/1.06 mg/mmol men/women. In 2006, the composite endpoint (CEP) of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease was recorded (n = 229).
Results:With in...
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiovascular risk Source Type: research
Cardiovascular risk assessment in low-resource settings: a consensus document of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk in Low Resource Settings
This report summarizes current evidence and presents highlights of unmet needs.
Source: Journal of Hypertension - April 7, 2014 Category: Cardiology Tags: Consensus Document Source Type: research
Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?
Conclusion:Our study showed that right-ventricular and right atrial mechanics, as well as exercise capacity, are significantly deteriorated in the hypertensive patients who are untreated or ineffectively treated. Global right-ventricular strain and 3DE right-ventricular stroke volume are independently associated with functional capacity in the whole study population.
Source: Journal of Hypertension - March 11, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research
Lower systolic blood pressure is associated with poorer survival in long-term survivors of stroke
Conclusion:There was a greater risk of poor outcome in long-term survivors of stroke with low SBP. This is further evidence that low SBP may result in poor prognosis. Ideal blood pressure levels for long-term survivors of stroke may need to be reassessed.
Source: Journal of Hypertension - March 11, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research
How far to lower blood pressure in the long term, after a stroke?
No abstract available
Source: Journal of Hypertension - March 11, 2014 Category: Cardiology Tags: Editorial Commentaries Source Type: research
Cost-effectiveness of Barostim therapy for the treatment of resistant hypertension in European settings
Conclusion:Barostim may be a cost-effective treatment when compared with optimal medical management in patients with resistant hypertension.
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Hypertension management Source Type: research
Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function
This study assessed the potential therapeutic benefit of combining the mitochondria-specific antioxidant, MitoQ10, with the low-dose angiotensin receptor blocker (ARB), losartan, on attenuation of hypertension and left ventricular hypertrophy. In parallel, we investigated the impact of MitoQ10 on cardiac hypertrophy in a neonatal cardiomyocyte cell line.
Methods and results:Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, n = 8–11) were treated with low-dose losartan (2.5 mg/kg per day); MitoQ10 (500 μmol/l); a combination of MitoQ10 and losartan (M + L); or vehicle for 8 weeks. Syst...
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Oxidative stress Source Type: research
Systolic blood pressure variability is an important predictor of cardiovascular outcomes in elderly hypertensive patients
Conclusion:These findings suggest that reducing visit-to-visit SBP variability might be an important objective in addition to conventional blood pressure-lowering in elderly hypertensive patients.
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: BP variability Source Type: research
Superoxide dismutase mimetic, tempol, aggravates renal injury in advanced-stage stroke-prone spontaneously hypertensive rats
Objective:The aim of this study was to determine whether antioxidant therapy could relieve hypertension and retard the progression of renal damage in advanced-stage hypertensive rats.
Methods:Twenty-four-week-old spontaneously hypertensive stroke-prone rats were treated for 8 weeks with the superoxide dismutase mimetic tempol, low-dose or high-dose candesartan (an angiotensin receptor blocker), or hydralazine, and blood pressure and renal damage were compared.
Results:Elevated blood pressure and renal damage with heterogeneity were present after 8 weeks, with greater glomerulosclerosis in the juxtamedullary glomeruli than ...
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Oxidative stress Source Type: research
