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Total 167 results found since Jan 2013.

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges
The objective of the workshop was to identify the challenges and opp ortunities of QSP as an approach to accelerate drug discovery and development in the field of CNS disorders. In particular, the workshop examined the potential for computational neuroscience to perform QSP‐based interrogation of the mechanism of action for CNS diseases, along with a more accurate and comprehensive method for evaluating drug effects and optimizing the design of clinical trials. Following up on an earlier white paper on the use of QSP in general disease mechanism of action and drug discovery, this report focuses on new applications, oppor...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 23, 2019 Category: Drugs & Pharmacology Authors: Hugo Geerts, John Wikswo, Piet H. Graaf, Jane P.F. Bai, Chris Gaiteri, David Bennett, Susanne E. Swalley, Edgar Schuck, Rima Kaddurah ‐Daouk, Katya Tsaioun, Mary Pelleymounter Tags: White Paper Source Type: research

Quantitative Systems Pharmacology (QSP) for Neuroscience Drug Discovery and Development: Current Status, Opportunities and Challenges
The objective of the workshop was to identify the challenges and opportunities of QSP as an approach to accelerate drug discovery and development in the field of CNS disorders. In particular, the workshop examined the potential for computational neuroscience to perform QSP ‐based interrogation of the mechanism of action for CNS diseases, along with a more accurate and comprehensive method for evaluating drug effects and optimizing the design of clinical trials.Following up on an earlier white paper on the use of QSP in general disease mechanism of action and drug discovery, this report focuses on new applications, opport...
Source: CPT: Pharmacometrics and Systems Pharmacology - October 31, 2019 Category: Drugs & Pharmacology Authors: Hugo Geerts, John Wikswo, Piet H. van der Graaf, Jane P.F Bai, Chris Gaiteri, David Bennett, Susanne E Swalley, Edgar Schuck, Rima Kaddurah ‐Daouk, Katya Tsaioun, Mary Pelleymounter Tags: WHITE PAPER Source Type: research

Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia: A Randomized Controlled Trial Protocol
Discussion: Positive results will increase the quality of life for persons with aphasia and their families while reducing societal costs. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines and successful integration within clinical routine.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03930121.
Source: Frontiers in Neurology - October 21, 2019 Category: Neurology Source Type: research

Development of a flexible rehabilitation concept for a neurological in-patient rehabilitation program after stroke.
CONCLUSION: The evidence-based and consensus-based concept is characterized by being individually and flexibly applicable to the individual patient. In this way, it meets the given demands and fulfils the requirements of a heterogeneous group of patients. It is intended to incorporate the treatment concept into the routine healthcare services offered by the AOK Baden-Württemberg. In addition, the treatment concept will be the basis for the development of performance-based remuneration. PMID: 31558374 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - September 29, 2019 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

A pilot evaluation of simulation-based interprofessional education for occupational therapy, speech pathology and dietetic students: improvements in attitudes and confidence.
Authors: Mills B, Hansen S, Nang C, McDonald H, Lyons-Wall P, Hunt J, O'Sullivan T Abstract Many higher education institutions struggle to provide interprofessional practice opportunities for their pre-licensure students due to demanding workloads, difficulties with timetabling, and problems with sourcing suitable placements that provide appropriate practice opportunities. A series of complex unfolding video-based simulation scenarios involving a patient who had experienced a stroke was utilized as a case study for a three-hour interprofessional practice workshop. 69 occupational therapy (OT), speech pathology (SP)...
Source: Journal of Interprofessional Care - September 20, 2019 Category: Health Management Tags: J Interprof Care Source Type: research

DCS or DCI? The difference and why it matters.
Authors: Mitchell SJ Abstract There are few issues that generate as much confusion in diving medicine as the nomenclature of bubble-induced dysbaric disease. Prior to the late 1980s, the diagnosis 'decompression sickness' (DCS) was invoked for symptoms presumed to arise as a consequence of bubble formation from dissolved inert gas during or after decompression. These bubbles were known to form within tissues, and also to appear in the venous blood (presumably after forming in tissue capillaries). A second diagnosis, 'arterial gas embolism' (AGE) was invoked for symptoms presumed to arise when bubbles were introduce...
Source: Diving and Hyperbaric Medicine - September 18, 2019 Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research

34 A Review of the Implementation of a Stroke Education Programme in a Dublin Teaching Hospital in 2018
ConclusionStaff applying the learned knowledge and competencies to Stroke patients has significantly improved following the commencement of the education.100% of staff who attended the Stroke study day stated that the training improved their knowledge and skills. 100% of staff would recommend the Stroke Study Day to other colleagues.We aim to continue the study days and whiteboard sessions with health professionals in all wards in 2019.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

IJERPH, Vol. 16, Pages 2409: The Importance of the Built Environment in Person-Centred Rehabilitation at Home: Study Protocol
Marie Elf Health services will change dramatically as the prevalence of home healthcare increases. Only technologically advanced acute care will be performed in hospitals. This—along with the increased healthcare needs of people with long-term conditions such as stroke and the rising demand for services to be more person-centred—will place pressure on healthcare to consider quality across the continuum of care. Research indicates that planned discharge tailored to individual needs can reduce adverse events and promote competence in self-management. However, the environmental factors that m...
Source: International Journal of Environmental Research and Public Health - July 5, 2019 Category: Environmental Health Authors: Maya Kyl én Lena Von Koch H élène Pessah-Rasmussen Elizabeth Marcheschi Charlotte Ytterberg Ann Heylighen Marie Elf Tags: Protocol Source Type: research

More Research Is Needed on Lifestyle Behaviors That Influence Progression of Parkinson's Disease
This article highlights some of these challenges in the design of lifestyle studies in PD, and suggests a more coordinated international effort is required, including ongoing longitudinal observational studies. In combination with pharmaceutical treatments, healthy lifestyle behaviors may slow the progression of PD, empower patients, and reduce disease burden. For optimal care of people with PD, it is important to close this gap in current knowledge and discover whether such associations exist. Introduction Parkinson's disease (PD) is an age-related complex progressive neurodegenerative disorder, with key p...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

A Kinematic Study of Progressive Micrographia in Parkinson's Disease
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of <10 years and 24 age-matched controls wrote the letter “e” repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson's Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last fi...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Cochrane ' s 30 under 30: Ndi Euphrasia Ebai-Atuh
Cochrane is made up of  13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all.  Many  of our contributors are young people working with Cochrane as researchers, citizen scientists...
Source: Cochrane News and Events - April 12, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Occupational therapists' perceptions of implementing a client-centered intervention in close collaboration with researchers: A mixed methods study.
CONCLUSION: The workshop context with facilitation and access to evidence, supportive organizations and teams, sufficient interaction with researchers and satisfying self-image were successful key factors when involved in research. PMID: 30905233 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - March 26, 2019 Category: Occupational Health Tags: Scand J Occup Ther Source Type: research