More Research Is Needed on Lifestyle Behaviors That Influence Progression of Parkinson's Disease
This article highlights some of these challenges in the design of lifestyle studies in PD, and suggests a more coordinated international effort is required, including ongoing longitudinal observational studies. In combination with pharmaceutical treatments, healthy lifestyle behaviors may slow the progression of PD, empower patients, and reduce disease burden. For optimal care of people with PD, it is important to close this gap in current knowledge and discover whether such associations exist. Introduction Parkinson's disease (PD) is an age-related complex progressive neurodegenerative disorder, with key pathological features being the presence of alpha-synuclein-containing Lewy bodies and a loss of dopaminergic neurons in the substantia nigra (1). Years to decades preceding diagnosis, symptoms can include constipation, sleep behavior disorder, hyposmia, and anxiety (2). At diagnosis, hallmark motor symptoms of bradykinesia, as well as either resting tremor or rigidity, are defining (3). The spectrum of motor and non-motor symptoms, and their impact on patient quality of life, suggests a need to individualize treatment. Current treatments primarily act to replace or boost existing dopamine, managing mostly motor symptoms. However, their long-term use leads to side effects, and reduced efficacy (4). Treatment of non-motor symptoms, including fatigue and cognitive impairment, is often secondary though they can have a significant impact on daily living (5, 6). ...
Publication date: December 2020Source: Tribology International, Volume 152Author(s): Chong Luo, Yi Xu, Nengyuan Zeng, Tengda Ma, Chenwei Wang, Yuling Liu
Publication date: Available online 2 August 2020Source: Journal of Membrane ScienceAuthor(s): Guang Yang, Zongli Xie, Aaron W. Thornton, Cara M. Doherty, Mingmei Ding, Hang Xu, Marlene Cran, Derrick Ng, Stephen Gray
Publication date: Available online 2 August 2020Source: Journal of Psychiatric ResearchAuthor(s): Mostafa Alikhani, Alireza Ebrahimi, Vahid Farnia, Habibolah Khazaie, Farnaz Radmehr, Elahe Mohamadi, Omran Davarinejad, Kenneth Dürsteler-MacFarland, Dena Sadeghi Bahmani, Serge Brand
This study included 250 subjects with NAFLD and 500 non-NAFLD controls. Clinical, anthropological and biochemical data were collected. Subjects with body mass index (BMI)>= 25 kg/m2 were taken as obese and subjects with BMI
Authors: Singh S, Lohakare AC Abstract Objective: Leptin levels are increased in obesity and have been found to be strongly associated with obesity, increased risk of cardiovascular diseases and morbidity. While, carotid intima-media thickness (CIMT) is measured to predict atherosclerosis in early phase. Thus, the objective of this study was to evaluate the leptin levels and CIMT in overweight and obese individuals. Methods: This cross-sectional study involving 95 subjects, was performed over a period of 1 year in the Department of Medicine, King George's Medical University, Lucknow. Anthropometric measurements...
Authors: Maydeo A, Patil G, Dalal A, Thakare S, Iyer A, Patil N Abstract Introduction: Endoscopic Sleeve gastroplasty (ESG) is a novel minimally invasive endoscopic restrictive bariatric procedure. We studied the safety, effectiveness, 6-month weight loss outcomes of ESG. Methods: We prospectively collected data for patients undergoing ESG at a tertiary care referral center. Laboratory investigations were performed preoperatively, and at 6 months post-operatively. Anthropometric measurements were noted pre and post-operatively at a frequency of 3 months for a 6-month follow-up. Patients with BMI ≥28 kg/m2 wh...
Esketamine nasal spray (Spravato), taken with an oral antidepressant, is now indicated in adults with major depression with acute suicidal ideation or behavior.Medscape Medical News
Publication date: October 2020Source: LWT, Volume 132Author(s): Po-Chuan Chen, Chi Lin, Min-Hung Chen, Po-Yuan Chiang
Publication date: Available online 3 August 2020Source: Food ControlAuthor(s): Siarhei Charapitsa, Svetlana Sytova, Anton Kavalenka, Lidia Sobolenko, Nikolai Kostyuk, Vladimir Egorov, Sergey Leschev, Sergey Vetokhin, Natalia Zayats
Publication date: Available online 2 August 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Tamara Borges Mariano, Bruna Higashi, Sheila Mara Sanches Lopes, José Walter Pedroza Carneiro, Rafaela Takako Ribeiro de Almeida, Eduardo Jorge Pilau, José Eduardo Gonçalves, Regina Aparecida Correia Gonçalves, Arildo José Braz de Oliveira
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