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Total 167 results found since Jan 2013.

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease
Exp Neurol. 2021 Oct 9:113891. doi: 10.1016/j.expneurol.2021.113891. Online ahead of print.ABSTRACTWe review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targete...
Source: Experimental Neurology - October 12, 2021 Category: Neurology Authors: Alicia K Vose Joseph F Welch Jayakrishnan Nair Erica A Dale Emily J Fox Gillian D Muir Randy D Trumbower Gordon S Mitchell Source Type: research

Healing Right Way: study protocol for a stepped wedge cluster randomised controlled trial to enhance rehabilitation services and improve quality of life in Aboriginal Australians after brain injury
This study will test the impact of a research-informed culturally secure intervention model for Aboriginal people with brain injury. Methods and analysis Design: Stepped wedge cluster randomised control trial design; intervention sequentially introduced at four pairs of healthcare sites across Western Australia at 26-week intervals. Recruitment: Aboriginal participants aged ≥18 years within 4 weeks of an acute stroke or traumatic brain injury. Intervention: (1) Cultural security training for hospital staff and (2) local, trial-specific, Aboriginal Brain Injury Coordinators supporting participants. Primary outcome: Qual...
Source: BMJ Open - September 28, 2021 Category: General Medicine Authors: Armstrong, E., Coffin, J., Hersh, D., Katzenellenbogen, J. M., Thompson, S., Flicker, L., McAllister, M., Cadilhac, D. A., Rai, T., Godecke, E., Hayward, C., Hankey, G. J., Drew, N., Lin, I., Woods, D., Ciccone, N. Tags: Open access, Health services research Source Type: research

Opportunities and limitations of risk adjustment of quality indicators based on inpatient administrative health data - a workshop report
DISCUSSION: Implementing specific risk adjustment models had only minor effects on the distribution of risk-adjusted mortality compared to the standard procedure, but the judgement of quality of care could change for a fifth of the hospitals in individual indicators. Concerning methodological and practical reasons, the task force recommends further development of risk adjustment methods for selected indicators. This should be accompanied by studies on the validity of inpatient administrative data for quality management as well as by efforts to improve the usefulness of these data for such purposes.PMID:34023246 | DOI:10.10...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 23, 2021 Category: Health Management Authors: Daniel Schwarzkopf Ulrike Nimptsch Raphael Graf Jochen Schmitt Josef Zacher Ralf Kuhlen Source Type: research

Unruptured aneurysms: Why observational studies fall short no matter how 'Big' the Data
CONCLUSION: To use POS rather than RCTs in medical practice is to renege on scientific and ethical principles that characterize modern medicine. Instead, we must learn to integrate care research into our practice to provide optimal medical care in real time.PMID:33713661 | DOI:10.1016/j.neuchi.2021.02.012
Source: Neurochirurgie - March 13, 2021 Category: Neurosurgery Authors: Tim E Darsaut Robert Fahed Jean Raymond Source Type: research