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Total 923 results found since Jan 2013.

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Jia Liu Lu-Ning Wang Source Type: research

Invited Commentary on the Postpartum Preeclampsia ECMO Case Conference
PREGNANCY, DESPITE its common nature and reputation as a “natural stage” of female existence, has profound physiologic effects. The cardiovascular system evolves as early as 6 weeks' gestation to establish appropriate uteroplacental circulation to support a growing fetus and supply the increased demands on maternal metabolism.1 Cardiac output increase s throughout pregnancy and can reach up to 150% of prepregnancy levels by the twenty-fourth week, and is largely achieved by an increase in stroke volume; cardiac magnetic resonance imaging demonstrates increases in left ventricular end-diastolic volume and left ventricular mass.
Source: Journal of Cardiothoracic and Vascular Anesthesia - January 8, 2023 Category: Anesthesiology Authors: Kristin Constantine Trela Tags: Invited Commentary Source Type: research

Invited Commentary to Postpartum Preeclampsia ECMO Case Conference
Pregnancy, despite its common nature and reputation as a “natural stage” of female existence, has profound physiological effects. The cardiovascular system evolves as early as six weeks gestation to establish appropriate uteroplacental circulation to support a growing fetus and supply the increased demands on maternal metabolism.1 Cardiac output incre ases throughout pregnancy and can reach up to 150% of pre-pregnancy levels by the twenty-fourth week and is largely achieved by an increase in stroke volume; cardiac magnetic resonance imaging demonstrates an increase in left ventricular end diastolic volume and left ventricular mass.
Source: Journal of Cardiothoracic and Vascular Anesthesia - January 8, 2023 Category: Anesthesiology Authors: Dr. Kristin Constantine Trela Tags: Invited Commentary Source Type: research

Colchicine in the Management of Acute Coronary Syndrome: A Meta-analysis
ConclusionsThese data suggest colchicine, in addition to guideline-directed medical therapy following acute coronary syndrome reduces MACE, cerebrovascular accidents, and rates of urgent revascularization at 2 years of follow-up.
Source: Cardiology and Therapy - January 6, 2023 Category: Cardiology Source Type: research

Prism adaptation combined with eye movement training for unilateral spatial neglect after stroke: Study protocol for a single-blind prospective, randomized controlled trial
This study will explore the effects of 10 sessions of combined interventions (PA & EMT) on USN and functional capacity. This study has the potential to identify a new, evidence-based treatment option and provide new ideas for the treatment of USN.Ethics and disseminationThe study protocol has been approved by the Nanchong Central Hospital. Written informed consent will be obtained from all the participants. The results of this study will be disseminated to the public through scientific conferences and a peer-reviewed journal.Trial registrationChiCTR, ChiCTR2100049482. Registered on 2 August 2021, http://www.chictr.org....
Source: Frontiers in Neurology - January 5, 2023 Category: Neurology Source Type: research

The virtual family conference in stroke rehabilitation: Education, preparation, and transition planning
CONCLUSIONS: The virtual family conference intervention demonstrated efficacy in facilitating carer education and preparation, along with discharge planning prior to community transition from stroke rehabilitation. Thus, illustrating potential benefits of family conferences and feasibility of their virtual application in stroke rehabilitative care.PMID:36575852 | DOI:10.1177/02692155221146448
Source: Clinical Rehabilitation - December 28, 2022 Category: Rehabilitation Authors: Benjamin R Ritsma Peter J Gariscsak Aarti Vyas Sophy Chan-Nguyen Ramana Appireddy Source Type: research

Combined robot motor assistance with neural circuit-based virtual reality (NeuCir-VR) lower extremity rehabilitation training in patients after stroke: a study protocol for a single-centre randomised controlled trial
Introduction Improving lower extremity motor function is the focus and difficulty of post-stroke rehabilitation treatment. More recently, robot-assisted and virtual reality (VR) training are commonly used in post-stroke rehabilitation and are considered feasible treatment methods. Here, we developed a rehabilitation system combining robot motor assistance with neural circuit-based VR (NeuCir-VR) rehabilitation programme involving procedural lower extremity rehabilitation with reward mechanisms, from muscle strength training, posture control and balance training to simple and complex ground walking training. The study aims ...
Source: BMJ Open - December 23, 2022 Category: General Medicine Authors: Zhou, Z.-Q., Hua, X.-Y., Wu, J.-J., Xu, J.-J., Ren, M., Shan, C.-L., Xu, J.-G. Tags: Open access, Rehabilitation medicine Source Type: research

Scientists tie third clinical trial death to experimental Alzheimer ’s drug
As enthusiasm mounts for a new experimental antibody that appears to slow cognitive decline in some Alzheimer’s patients, a third death linked to the drug during its clinical testing may amplify concerns about its safety. Science has obtained medical records showing a 79-year-old Florida woman participating in an ongoing trial of the antibody died in mid-September after experiencing extensive brain swelling and bleeding, as well as seizures. Multiple neuroscientists who reviewed the records at Science ’s request believe her death was likely caused by the antibody, lecanemab. “The brain swelling and t...
Source: ScienceNOW - December 21, 2022 Category: Science Source Type: news

Falls, stroke, communication disability: content analysis of medical records and incident reports conference abstract #170 - Sullivan R, Harding K, Skinner I, Hemsley B.
Proceedings of the 14th World Conference on Injury Prevention and Safety Promotion (Safety 2022) Background Patients with communication disability following stroke are often excluded from falls research. Aim This researched aimed to identify the circu...
Source: SafetyLit - December 1, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Stroke, communication disability and falls: analysis of medical records and incident reports conference abstract #172 - Sullivan R, Harding K, Skinner I, Hemsley B.
Proceedings of the 14th World Conference on Injury Prevention and Safety Promotion (Safety 2022) Background Patients with communication disability following stroke are at increased risk for adverse events including falls. However, they are often exclude...
Source: SafetyLit - December 1, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research

Impact of health literacy and its interventions on health outcomes in those with atrial fibrillation: a systematic review protocol
Introduction Atrial fibrillation (AF) is associated with increased risk of stroke, heart failure and death. Health literacy, an aspect that falls within precision health, has been recognised as an important factor. We will be focusing on the impact of these interventions specifically to AF and its health outcomes. Methods and analysis This protocol is informed by the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols. The results will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses to determine the impacts of health literacy interventions on AF outco...
Source: BMJ Open - December 1, 2022 Category: General Medicine Authors: Lathlean, T., Kieu, D., Franke, K. B., O'Callaghan, N., Boyd, M. A., Mahajan, R. Tags: Open access, Cardiovascular medicine Source Type: research

Bi-atrial versus left atrial ablation for patients with rheumatic mitral valve disease and non-paroxysmal atrial fibrillation (ABLATION): rationale, design and study protocol for a multicentre randomised controlled trial
Introduction Atrial fibrillation (AF) is common in patients with rheumatic mitral valve disease (RMVD) and increase the risk of stroke and death. Bi-atrial or left atrial ablation remains controversial for treatment of AF during mitral valve surgery. The study aims to compare the efficacy and safety of bi-atrial ablation with those of left atrial ablation among patients with RMVD and persistent or long-standing persistent AF. Methods and analysis The ABLATION trial (Bi-atrial vs Left Atrial Ablation for Patients with RMVD and Non-paroxysmal AF) is a prospective, multicentre, randomised controlled study. The trial will ran...
Source: BMJ Open - November 29, 2022 Category: General Medicine Authors: Yu, C., Li, H., Wang, Y., Chen, S., Zhao, Y., Zheng, Z. Tags: Open access, Cardiovascular medicine Source Type: research

Acupuncture improves the residual urine volume of bladder of middle age patients with urinary retention post-stroke: A protocol for systematic review and meta analysis
Conclusion: The residual urine volume of bladder will be the primary outcome measure, whereas the Clinical efficiency will be the secondary outcomes. Side effects and adverse events will be included as safety evaluations. To ensure the quality of the systematic evaluation, study selection, data extraction, and quality assessment will be independently performed by two authors, whereas a third author will resolve any disagreement.
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research