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Total 923 results found since Jan 2013.

Repetitive transcranial magnetic stimulation for upper limb motor function and activities of daily living in patients with stroke: a protocol of a systematic review and Bayesian network meta-analysis
Introduction Patients with stroke usually suffer from varying degrees of movement dysfunction, which seriously affects their quality of life, especially for the upper limb dysfunction. Therefore, this study aims to compare the effects of different repetitive transcranial magnetic stimulation (rTMS) modalities on upper limb motor function and daily activities in patients with stroke. Methods and analysis Relevant research will be collected systematically from PubMed, Web of Science, Embase, Cochrane Library, ProQuest, Wanfang Database, China National Knowledge Infrastructure and Chinese Scientific and Journal Database (VIP...
Source: BMJ Open - March 10, 2022 Category: General Medicine Authors: Lu, Y., Xia, Y., Wu, Y., Pan, X., Wang, Z., Li, Y. Tags: Open access, Evidence based practice Source Type: research

Telerehabilitation for lower extremity recovery poststroke: a systematic review and meta-analysis protocol
Introduction Approximately 30% of individuals with stroke report unmet lower extremity recovery needs after formal hospital-based rehabilitation programmes have ended. Telerehabilitation can mitigate issues surrounding accessibility of rehabilitation services by providing ongoing support to promote recovery, however, no review exists that is specific to telerehabilitation for lower extremity recovery. This paper describes the protocol of a systematic review and meta-analysis that aims to describe and evaluate the effectiveness of lower extremity-focused telerehabilitation interventions on clinical outcomes poststroke. Met...
Source: BMJ Open - March 9, 2022 Category: General Medicine Authors: Park, S., Tang, A., Pollock, C., Sakakibara, B. M. Tags: Open access, Rehabilitation medicine Source Type: research

Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial
Introduction Cardiovascular disease is a leading cause of death globally, responsible for nearly 18 million deaths worldwide in 2017. Medications to reduce the risk of cardiovascular events are prescribed based on evidence from clinical trials which explore treatment effects in an indicated sample of the general population. However, these results may not be fully generalisable because of trial eligibility criteria that generally restrict to younger patients with fewer comorbidities. Therefore, evidence of effectiveness of medications for groups underrepresented in clinical trials such as those aged ≥75 years, from ethni...
Source: BMJ Open - March 8, 2022 Category: General Medicine Authors: Baptiste, P. J., Wong, A. Y. S., Schultze, A., Cunnington, M., Mann, J. F. E., Clase, C., Leyrat, C., Tomlinson, L. A., Wing, K. Tags: Open access, Epidemiology Source Type: research

Antiplatelet agents for chronic kidney disease
CONCLUSIONS: Antiplatelet agents probably reduced myocardial infarction and increased major bleeding, but do not appear to reduce all-cause and cardiovascular death among people with CKD and those treated with dialysis. The treatment effects of antiplatelet agents compared with each other are uncertain.PMID:35224730 | DOI:10.1002/14651858.CD008834.pub4
Source: Cochrane Database of Systematic Reviews - February 28, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Valeria M Saglimbene Marinella Ruospo Mona Razavian Jonathan C Craig Meg J Jardine Angela C Webster Giovanni Fm Strippoli Source Type: research

A Meta-Analysis of Using Protamine for Reducing the Risk of Hemorrhage During Carotid Recanalization: Direct Comparisons of Post-operative Complications
Conclusion: Among included participants undergoing recanalization, the use of protamine is effective in reducing hematoma without increasing the risk of having other complications. Besides, more evidence-based performance is needed to supplement this opinion due to inherent limitations.
Source: Frontiers in Pharmacology - February 25, 2022 Category: Drugs & Pharmacology Source Type: research

American Stroke Association, Feb. 9-11
The annual International Stroke Conference of the American Heart Association/American Stroke Association was held from Feb. 9 to 11 in New Orleans and attracted participants from around the world, including cerebrovascular research and practice...
Source: Drugs.com - Pharma News - February 22, 2022 Category: Pharmaceuticals Source Type: news

Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)--rationale and protocol for a prospective multicentre observational study
This study aims to investigate risk factors, clinical course, cerebral and retinal imaging changes, proteomics features of non-symptomatic ischaemia symptomatic patients with cognitive decline. Methods and analysis The Non-Acute Symptomatic Cerebral Ischemia Registration study is a multicentre, registry-based, prospective observational study, is designed to investigate the cognitive decline in non-acute ischaemia symptomatic patients. We will recruit 500 non-acute ischaemia symptomatic patients from four tertiary hospitals in China. For this study, non-acute ischaemia symptoms will be defined as headaches, dizziness and m...
Source: BMJ Open - February 22, 2022 Category: General Medicine Authors: Zhang, S., Wang, Z., Liu, P., Tuo, Q., Cheng, Y., Xu, M., Wu, Q., Lei, P., Dai, L., Kwapong, W. R., Tan, M., Liu, M. Tags: Open access, Neurology Source Type: research

When the cupboard is bare: Impact of low pay revealed by conference
On a busy opening day of UNISON’s women’s conference – held virtually because of the continuing pandemic – delegates worked hard to ensure they have every chance of getting through the entire agenda. Irene Graham from Northern Ireland told delegates about that region’s relaunch of the Feminist Recover Plan, which highlights the effects of both the pandemic and Brexit on women. Conference voted to support the region’s plan and called on the national committee to use it as a model to shape its future work. Describing the struggle low-paid women workers have to survive on “on the hamster wheel of life”, Laura ...
Source: UNISON meat hygiene - February 18, 2022 Category: Food Science Authors: Amanda Kendal Tags: Article News 2022 National Womens Conference Source Type: news

Morbidity and mortality in patients managed with high compared with low blood pressure targets during on-pump cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
ConclusionIndividual trial definitions of high and low blood pressure targets varied, limiting inferences. The effect of high (compared with low) blood pressure targets on other morbidity and mortality after cardiac surgery remains unclear because of limitations with the body of existing evidence. Research to determine the optimal management of blood pressure during cardiac surgery is required.Study registrationPROSPERO (CRD42020177376); registered: 5 July 2020.
Source: Canadian Journal of Anesthesia - February 17, 2022 Category: Anesthesiology Source Type: research

Effectiveness of transcranial direct current stimulation on hand dexterity in stroke patients: a protocol for a systematic review and meta-analysis
Introduction Hand dexterity is the ability to execute the skilful movements using the hand and fingers. It is commonly impaired poststroke resulting in a profound deterioration in the quality of life for patients with stroke. Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation, which has gained a popularity as an adjunct therapy in recovering motor dysfunction poststroke. Promising results have been gained from applying tDCS in combination with motor rehabilitation, however, the outcome of tDCS on the upper limb motor function poststroke has been varied. Different results are potentia...
Source: BMJ Open - February 16, 2022 Category: General Medicine Authors: Alabdulaali, L., Hickman, L., Punt, T. D., Jenkinson, N. Tags: Open access, Rehabilitation medicine Source Type: research

Endovascular thrombectomy without versus with intravenous thrombolysis in acute ischemic stroke: a non-inferiority meta-analysis of randomized clinical trials
Conclusions This meta-analysis suggests that EVT alone is non-inferior to IVT plus EVT for several, but not the most stringent, non-inferiority margins.
Source: Journal of NeuroInterventional Surgery - February 16, 2022 Category: Neurosurgery Authors: Lin, C.-H., Saver, J. L., Ovbiagele, B., Huang, W.-Y., Lee, M. Tags: Open access, Ischemic stroke Source Type: research

TACTICS - Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an 'implementation intervention' in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke
BMJ Open. 2022 Feb 11;12(2):e055461. doi: 10.1136/bmjopen-2021-055461.ABSTRACTINTRODUCTION: Stroke reperfusion therapies, comprising intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), are best practice treatments for eligible acute ischemic stroke patients. In Australia, EVT is provided at few, mainly metropolitan, comprehensive stroke centres (CSC). There are significant challenges for Australia's rural and remote populations in accessing EVT, but improved access can be facilitated by a 'drip and ship' approach. TACTICS (Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship) aim...
Source: Rural Remote Health - February 12, 2022 Category: Rural Health Authors: Annika Ryan Christine L Paul Martine Cox Olivia Whalen Andrew Bivard John Attia Christopher Bladin Stephen M Davis Bruce C V Campbell Mark Parsons Rohan S Grimley Craig Anderson Geoffrey A Donnan Christopher Oldmeadow Sarah Kuhle Frederick R Walker Rebecc Source Type: research