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Total 923 results found since Jan 2013.

Calligraphy-based rehabilitation exercise for improving the upper limb function of stroke patients: protocol for an evaluator-blinded randomised controlled trial
This study aims to design a randomised controlled trial to assess the effect of a customised CCH-based exercise for poststroke rehabilitation of upper limb dysfunction. Methods and analysis A single-blinded randomised controlled trial will be conducted on 60 stroke patients. The patients will be randomly allocated into three groups: (1) conventional occupational therapy (COT) group, (2) COT+CCH group, (3) COT+Graded Repetitive Arm Supplementary Program (GRASP) group. For the COT group, patients will receive COT treatment of 1 hour/day. For the COT+CCH group, patients will receive 30 mins COT treatment and 30 mins CCH trai...
Source: BMJ Open - May 13, 2022 Category: General Medicine Authors: Wu, X., Zhang, Q., Qiao, J., Chen, N., Wu, X. Tags: Open access, Rehabilitation medicine Source Type: research

Do P2Y12 receptor inhibitors prescribed poststroke modify the risk of cognitive disorder or dementia? Protocol for a target trial using multiple national Swedish registries
This study has been approved by the Ethics Committee of the University of Gothenburg and Confidentiality Clearance at Statistics Sweden with Dnr 937-18, and an approved addendum with Dnr 2019-0157. The analysis and interpretation of the results will be heavily reliant on the structure, quality and potential for bias of the databases used. When we implement the protocol, we will consider and document any biases specific to the dataset and conduct appropriate sensitivity analyses. Findings will be disseminated to local stakeholders via conferences, and published in appropriate scientific journals.
Source: BMJ Open - May 9, 2022 Category: General Medicine Authors: Hinwood, M., Nyberg, J., Leigh, L., Gustavsson, S., Attia, J., Oldmeadow, C., Ilicic, M., Linden, T., Aberg, N. D., Levi, C., Spratt, N., Carey, L. M., Pollack, M., Johnson, S. J., Kuhn, G. H., Walker, F. R., Nilsson, M. Tags: Open access, Neurology Source Type: research

Certain gut microbes may affect stroke risk and severity, scientists find
Studies of ischaemic stroke patients open up possibility of treatments to prevent condition and improve recoveryScientists have identified specific groups of gut microbes that could increase or decrease someone ’s risk of suffering the most common type of stroke. The research, presented at the European Stroke Organisation Conference (ESOC) in Lyon, France, adds to growing evidence that alterations in the gut microbiome could play a role in cardiovascular disease.Previous studies have suggested that certain microbes may influence the formation of atherosclerotic plaques in the arteries, and that the gut microbiomes of str...
Source: Guardian Unlimited Science - May 4, 2022 Category: Science Authors: Linda Geddes Science correspondent Tags: Stroke Biology Science Microbiology Health Medical research Source Type: news

UN Aims at People-Centered Governance in a Post-Pandemic World
A rescued boat woman and her two children eat some welcome food at a centre in Kuala Cangkoi, Indonesia. The UN urges 'people-centred' approach to migrants and refugees in Southeast Asia. Credit: UNHCRBy Simone GalimbertiKATHMANDU, Nepal, Apr 29 2022 (IPS) The recently disseminated Zero Draft Ministerial Declaration of the High-Level Political Forum on Sustainable Development (HLPF)– the main UN event to track the member states’ progress to achieve the Agenda 2030 slated to be held in the first half of July– is a disappointment. For all its comprehensiveness, the document neglected to mention one of the most...
Source: IPS Inter Press Service - Health - April 29, 2022 Category: International Medicine & Public Health Authors: Simone Galimberti Tags: COVID-19 Development & Aid Featured Food and Agriculture Global Global Governance Headlines Poverty & SDGs TerraViva United Nations IPS UN Bureau Source Type: news

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (Mobile Stroke Unit--TASTE-A): protocol for a prospective randomised, open-label, blinded endpoint, phase II superiority trial of tenecteplase versus alteplase for ischaemic stroke patients presenting within 4.5 hours of symptom onset to the mobile stroke unit
Introduction Mobile stroke units (MSUs) equipped with a CT scanner are increasingly being used to assess and treat stroke patients’ prehospital with thrombolysis and transfer them to the most appropriate hospital for ongoing stroke care and thrombectomy when indicated. The effect of MSUs in both reducing the time to reperfusion treatment and improving patient outcomes is now established. There is now an opportunity to improve the efficacy of treatment provided by the MSU. Tenecteplase is a potent plasminogen activator, which may have benefits over the standard of care stroke lytic alteplase. Specifically, in the MSU ...
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Bivard, A., Zhao, H., Coote, S., Campbell, B., Churilov, L., Yassi, N., Yan, B., Valente, M., Sharobeam, A., Balabanski, A., Dos Santos, A., Ng, F., Langenberg, F., Stephenson, M., Smith, K., Bernard, S., Thijs, V., Cloud, G., Choi, P., Ma, H., Wijeratne, Tags: Open access, Neurology Source Type: research

Exploring the experiences and challenges for patients undergoing cranioplasty: a mixed-methods study protocol
This study hopes to understand some of these issues and therefore help inform clinicians of some of the difficulties and perceptions that patients and their relatives may have. Methods and analysis A mixed-methods study. Data will be collected through focus groups with healthcare professionals (HCPs) and semi-structured interviews with patients and their relatives, field notes, a researcher diary and a patient questionnaire. Different perspectives will be brought together through method triangulation. Patient and relative data will be analysed using interpretive phenomenological analysis, and HCPs data will be analysed th...
Source: BMJ Open - April 22, 2022 Category: General Medicine Authors: Mee, H., Clement, C., Anwar, F., Whiting, G., Timofeev, I., Helmy, A., Hutchinson, P. J., Kolias, A. G. Tags: Open access, Rehabilitation medicine Source Type: research

Sex differences in outcomes after mechanical thrombectomy for acute ischemic stroke in the 'real world: protocol for a systematic review and meta-analysis study
Introduction Mechanical thrombectomy (MT) had been regarded as the first-line therapy for acute ischaemic stroke patients. The sex differences in post-MT treatment outcomes were analysed by randomised controlled trial (RCT) studies with inconsistent conclusions. We suggest the results from the real-world data may differ from RCT containing studies. Therefore, the sex difference in non-clinical trial populations needs to be clarified. Methods and analysis In order to obtain relative studies comprehensively, we will search the main document databases, consisting of Web of Science, Medline in Ovid, Embase in Ovid and Cochran...
Source: BMJ Open - April 15, 2022 Category: General Medicine Authors: Xu, L., Li, B., Zhang, X., Bai, X., Dmytriw, A. A., Wang, T., Wang, X., Yang, K., Min, X., Jiao, L. Tags: Open access, Neurology Source Type: research

Utility of a smartphone application in assessing palmar circulation prior to radial artery harvesting for coronary artery bypass grafting: rationale and design of the randomised CAPITAL iRADIAL-CABG trial
Introduction There is emerging evidence supporting the use of the radial artery (RA) as a preferred secondary conduit for coronary artery bypass grafting (CABG) as it is associated with higher rates of graft patency at 5 years when compared with saphenous vein grafts (SVG). The modified Allen’s test (MAT) is traditionally regarded as the standard of care in the assessment of ulnar artery (UA) patency prior to RA harvesting. Unfortunately, due to high false-positive rates, a substantial number of pre-CABG patients are found to have an abnormal MAT despite normal UA patency, resulting in inappropriate exclusion from RA...
Source: BMJ Open - April 8, 2022 Category: General Medicine Authors: Goh, C. Y., Parlow, S., Di Santo, P., Simard, T., Jung, R., Ahmed, Z., Verreault-Julien, L., Kuhar, P., Chan, V., Al-Atassi, T., Toeg, H., Bernick, J., Wells, G. A., Ruel, M., Hibbert, B. Tags: Open access, Cardiovascular medicine Source Type: research

FAST-IT: Find A Simple Test -- In TIA (transient ischaemic attack): a prospective cohort study to develop a multivariable prediction model for diagnosis of TIA through proteomic discovery and candidate lipid mass spectrometry, neuroimaging and machine learning--study protocol
Introduction Transient ischaemic attack (TIA) may be a warning sign of stroke and difficult to differentiate from minor stroke and TIA-mimics. Urgent evaluation and diagnosis is important as treating TIA early can prevent subsequent strokes. Recent improvements in mass spectrometer technology allow quantification of hundreds of plasma proteins and lipids, yielding large datasets that would benefit from different approaches including machine learning. Using plasma protein, lipid and radiological biomarkers, our study will develop predictive algorithms to distinguish TIA from minor stroke (positive control) and TIA-mimics (n...
Source: BMJ Open - April 1, 2022 Category: General Medicine Authors: Milton, A. G., Lau, S., Kremer, K. L., Rao, S. R., Mas, E., Snel, M. F., Trim, P. J., Sharma, D., Edwards, S., Jenkinson, M., Kleinig, T., Noschka, E., Hamilton-Bruce, M. A., Koblar, S. A. Tags: Open access, Health services research Source Type: research

Protocol for GUos renovisceral Artery reconstruction-1: a prospective, multicentre, single-arm clinical trial to evaluate the safety and efficacy of a multibRANched sTEnt graft systEm for thoracoabdominal aortic aneurysm (GUARANTEE study)
Introduction The multibranched off-the-shelf stent graft is a promising treatment option for thoracoabdominal aortic aneurysm (TAAA). A commercially available, multibranched, off-the-shelf endograft called the t-Branch stent graft has demonstrated favourable midterm outcomes. Another two investigational off-the-shelf endografts, the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis and E-nside multibranch stent graft system, are still being developed. However, these three endografts have an unsatisfactory anatomic feasibility rate in patients with TAAA. Based on the concept of Guo’s renovisceral artery reconstruct...
Source: BMJ Open - March 23, 2022 Category: General Medicine Authors: Ge, Y., Zhang, H., Rong, D., Liu, F., Jia, X., Xiong, J., Ma, X., Wang, L., Fan, T., Guo, W. Tags: Open access, Cardiovascular medicine Source Type: research

The African Stroke Organization Conference 2021: Building Capacity, Careers, Collaborations, and Contributions
The inaugural African Stroke Organization Conference (ASOC) aimed to create a forum to discuss the latest stroke science, highlight opportunities to address the high burden of stroke in Africa, develop a viable pipeline of emerging African stroke researchers, honor leading scientists and policy makers, and provide networking avenues to bolster future collaboration. Using a virtual platform, ASOC was held from Nov 3-4, 2021, and was attended by 236 participants. ASOC 2021 sessions included: (1) Osuntokun Award Lecture delivered by Prof.
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2022 Category: Neurology Authors: Mehari Gebreyohanns, Rufus O. Akinyemi, Mayowa O Owolabi, Fred Stephen Sarfo, Raelle Tagge, Bruce Ovbiagele Source Type: research

RETurn to work After stroKE (RETAKE) Trial: protocol for a mixed-methods process evaluation using normalisation process theory
Objectives This mixed-method process evaluation underpinned by normalisation process theory aims to measure fidelity to the intervention, understand the social and structural context in which the intervention is delivered and identify barriers and facilitators to intervention implementation. Setting RETurn to work After stroKE (RETAKE) is a multicentre individual patient randomised controlled trial to determine whether Early Stroke Specialist Vocational Rehabilitation (ESSVR) plus usual care is a clinically and cost-effective therapy to facilitate return to work after stroke, compared with usual care alone. This protocol ...
Source: BMJ Open - March 15, 2022 Category: General Medicine Authors: Radford, K. A., McKevitt, C., Clarke, S., Powers, K., Phillips, J., Craven, K., Watkins, C., Farrin, A., Holmes, J., Cripps, R., McLellan, V., Sach, T., Brindle, R., Holloway, I., Hartley, S., Bowen, A., O'Connor, R. J., Stevens, J., Walker, M., Murray, J Tags: Open access, Cardiovascular medicine Source Type: research

Highlights From the International Stroke Conference 2022 —Thrombectomy and Alteplase, Access to Stroke Centers, and Warfarin vs Direct Oral Anticoagulants
Timely topics discussed at the AHA/ASA ’s International Stroke Conference included giving stroke patients intra-arterial alteplase following successful thrombectomy.
Source: JAMA - March 15, 2022 Category: General Medicine Source Type: research

Rationale and design for comparison of non-compliant balloon with drug-coating balloon angioplasty for side branch after provisional stenting for patients with true coronary bifurcation lesions: a prospective, multicentre and randomised DCB-BIF trial
Introduction Provisional stenting using drug-eluting stent is effective for simple coronary bifurcation lesions. Kissing balloon inflation using conventional non-compliant balloon is the primary treatment of side branch (SB) after main vessel (MV) stenting. Drug-coating balloon (DCB) is reported to be associated with less frequent clinical events in in-stent restenosis and small vessel disease. The importance of DCB in bifurcation treatment is understudied. Accordingly, this trial is designed to investigate the superiority of DCB to non-compliant balloon angioplasty for SB after provisional stenting in patients with true c...
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Gao, X.-F., Ge, Z., Kan, J., Kong, X.-Q., Wang, Y., Qiu, C.-G., Tresukosol, D., He, Y.-Q., Wu, Q., Li, J.-F., Yuan, H.-T., Shen, C., Chen, X., Munawar, M., Hanif, B., Santoso, T., Shin, E.-S., Sheiban, I., Ye, F., Zhang, J.-J., Chen, S.-L., On behalf of t Tags: Open access, Cardiovascular medicine Source Type: research

Evaluation of a community-based performance arts programme for people who have experienced stroke in the UK: protocol for the SHAPER-Stroke Odysseys study
In this study, we aim to evaluate the implementation, impact and experiences of SO for stroke survivors. Methods and analysis Scaling-up Health Arts Programmes: Implementation and Effectiveness Research (SHAPER)-SO aims to scale-up SO to 75 participants and 47 stakeholders, while simultaneously evaluating the effectiveness and implementation of the programme. The main research aim is to evaluate the implementation, effectiveness, impact and experiences of a community-based performance arts programme (SO for stroke survivors). This mixed-methods study will evaluate the experience and impact of SO on those participating usi...
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Estevao, C., Baldellou Lopez, M., Davis, R. E., Jarret, L., Soukup, T., Bakolis, I., Healey, A., Harrington, J., Woods, A., Crane, N., Jones, F., Pariante, C., Fancourt, D., Sevdalis, N. Tags: Open access, Qualitative research Source Type: research