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Drug: Magnesium
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Total 248 results found since Jan 2013.
Treating stroke patients with intravenous magnesium within an hour of symptom onset fails to improve stroke outcome
In the first study of its kind, a consortium of physicians found that giving stroke patients intravenous magnesium within an hour of symptom onset does not improve stroke outcomes, according to research.
Source: ScienceDaily Headlines - February 13, 2014 Category: Science Source Type: news
Quick magnesium treatment fails to improve stroke outcomes, but study has silver lining
In the first study of its kind, a consortium led by UCLA physicians found that giving stroke patients intravenous magnesium within an hour of the onset of symptoms does not improve stroke outcomes.
However, the 8-year trial did find that with the help of paramedics in the field, intravenous medications can frequently be administered to stroke victims within that so-called "golden hour," during which they have the best chance to survive and avoid debilitating, long-term neurological damage.
The latter finding is a "game-changer," said Dr. Jeffrey Saver, director of the UCLA Stroke Center and a professor of ...
Source: UCLA Newsroom: Health Sciences - February 13, 2014 Category: Universities & Medical Training Source Type: news
Heme iron intake and acute myocardial infarction: A prospective study of men
Conclusions: Findings from this prospective study indicate that a high heme iron intake, particularly with simultaneous low intake of minerals that can decrease iron absorption, may increase the risk of fatal AMI.
Source: International Journal of Cardiology - January 22, 2014 Category: Cardiology Authors: Joanna Kaluza, Susanna C. Larsson, Niclas Håkansson, Alicja Wolk Tags: Original Articles Source Type: research
Methodology of the Field Administration of Stroke Therapy – Magnesium (FAST‐MAG) phase 3 trial: Part 2 – prehospital study methods
DiscussionThe suite of prehospital trial methods developed for the FAST‐MAG Trial enable enrollment of patients in very early time windows, including the hyperacute, ‘golden hour’ period immediately after stroke onset.
Source: International Journal of Stroke - January 20, 2014 Category: Neurology Authors: Jeffrey L. Saver, Sidney Starkman, Marc Eckstein, Samuel Stratton, Frank Pratt, Scott Hamilton, Robin Conwit, David S. Liebeskind, Gene Sung, Nerses Sanossian, Tags: Protocol Source Type: research
Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-like Episodes (MELAS) May Respond to Adjunctive Ketogenic Diet
Conclusions: The ketogenic diet may lead to improvement of mitochondrial dysfunction in MELAS, which in turn may promote better seizure control and less frequent stroke-like episodes.
Source: Pediatric Neurology - January 9, 2014 Category: Neurology Authors: Claude Steriade, Danielle M. Andrade, Hanna Faghfoury, Mark A. Tarnopolsky, Peter Tai Tags: Clinical Observations Source Type: research
Methodology of the Field Administration of Stroke Therapy – Magnesium (FAST‐MAG) phase 3 trial: Part 1 – rationale and general methods
RationalePrehospital initiation by paramedics may enable delivery of neuroprotective therapies to stroke patients in the hyperacute period when they are most effective in preclinical studies. Magnesium is neuroprotective in experimental stroke models and has been shown to be safe with signals of potential efficacy when started early after onset of human cerebral ischemia.
Aims(a) To demonstrate that paramedic initiation of the neuroprotective agent magnesium sulfate in the field is an efficacious and safe treatment for acute stroke; (b) To demonstrate that field enrollment of acute stroke patients is a practical and feasib...
Source: International Journal of Stroke - January 1, 2014 Category: Neurology Authors: Jeffrey L. Saver, Sidney Starkman, Marc Eckstein, Samuel Stratton, Frank Pratt, Scott Hamilton, Robin Conwit, David S. Liebeskind, Gene Sung, Nerses Sanossian, Tags: Protocols Source Type: research
What Causes Muscle Weakness?
Discussion
Muscle tone is the slight tension that is felt in a muscle when it is voluntarily relaxed. It can be assessed by asking the patient to relax and then taking the muscles through a range of motion such as moving the wrists, forearm and upper arm. Muscle strength is the muscle’s force against active resistance. Impaired strength is called weakness or paresis. There are 5 levels of muscle strength.
0 = No muscle contraction detected
1 = Barely detected flicker of contraction
2 = Active movement with gravity eliminated
3 = Active movement against gravity
4 = Active movement against gravity and some resistance
...
Source: PediatricEducation.org - December 9, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery Clinical Sciences
Conclusions—
Magnesium administered intravenously during cardiac surgery does not reduce postoperative cognitive dysfunction.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00041392.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Mathew, J. P., White, W. D., Schinderle, D. B., Podgoreanu, M. V., Berger, M., Milano, C. A., Laskowitz, D. T., Stafford-Smith, M., Blumenthal, J. A., Newman, M. F., for the Neurologic Outcome Research Group (NORG) of The Duke Heart Center, Neurologic Out Tags: Clinical Sciences Source Type: research
Treating cerebral ischemia-reperfusion injuries with salvianolate
Salvianolic acid B, also called salvia magnesium acetate, is a phenolic acid compound composed of three Danshensu units and one molecule of caffeic acid. Salvianolic acid B exerts strong resistance to oxidative stress and inflammatory reaction, and improves energy metabolism against cerebral ischemia-reperfusion injuries. Dr...
Source: Health News from Medical News Today - October 28, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
The high heart health value of drinking-water magnesium
Abstract: Universal drinking water and beverages containing moderate to high levels of magnesium (10–100ppm) could potentially prevent 4.5million heart disease and stroke deaths per year, worldwide. This potential is calculated with 2010 global mortality figures combined with a recent quantification of water-magnesium’s inverse association with heart disease and stroke mortality. The modern processed food diet, low in magnesium and spreading globally, makes this well-researched potential of drinking-water magnesium worth serious consideration, especially in areas where insufficient dietary intake of magnesium is prevalent.
Source: Medical Hypotheses - October 28, 2013 Category: Biomedical Science Authors: Andrea Rosanoff Tags: Articles Source Type: research
Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research
Dietary intakes consistent with the DASH dietary pattern reduce blood pressure increase with age and risk for stroke in a Chinese population.
In conclusion, adhering to the DASH diet is beneficial for long term BP control and reduction of stroke risk in this Chinese population.
PMID: 24066367 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - October 1, 2013 Category: Nutrition Authors: Lin PH, Yeh WT, Svetkey LP, Chuang SY, Chang YC, Wang C, Pan WH Tags: Asia Pac J Clin Nutr Source Type: research
Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research
Dietary intakes consistent with the DASH dietary pattern reduce blood pressure increase with age and risk for stroke in a Chinese population.
In conclusion, adhering to the DASH diet is beneficial for long term BP control and reduction of stroke risk in this Chinese population.
PMID: 23945400 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - August 19, 2013 Category: Nutrition Authors: Lin PH, Yeh WT, Svetkey LP, Chuang SY, Chang YC, Wang C, Pan WH Tags: Asia Pac J Clin Nutr Source Type: research
Acute Decrease in Serum Magnesium Level after Ischemic Stroke May Not Predict Decrease in Neurologic Function
Conclusions: Our results suggest that patients who have low Mg(2+) at baseline or a reduction in Mg(2+) 24 hours after admission are not at a higher risk of experiencing ND or poor short-term outcome. Ongoing prospective interventional trials will determine if hyperacute aggressive magnesium replacement affords neuroprotection in stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: James E. Siegler, Amelia K. Boehme, Karen C. Albright, Sami Bdeir, Anoop K. Kar, Leann Myers, T. Mark Beasley, Sheryl Martin-Schild Tags: Original Articles Source Type: research
