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Total 248 results found since Jan 2013.

Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage
Opinion statement New neuroprotective treatments aimed at preventing or minimizing “delayed brain injury” are attractive areas of investigation and hold the potential to have substantial beneficial effects on aneurysmal subarachnoid hemorrhage (aSAH) survivors. The underlying mechanisms for this “delayed brain injury” are multi-factorial and not fully understood. The most ideal treatment strategies would have the potential for a pleotropic effect positively modulating multiple implicated pathophysiological mechanisms at once. My personal management (RFJ) of patients with aneurysmal subarachnoid hemorrhage...
Source: Current Treatment Options in Neurology - June 19, 2016 Category: Neurology Source Type: research

MassDevice.com +5 | The top 5 medtech stories for June 15, 2016
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Biotronik wins CE Mark for Magmaris bioresorbable scaffold Biotronik said today it won CE Mark for its Magmaris magnesium bioresorbable scaffold designed to treat coronary artery disease. Data from the Biosolve-II trial of the ...
Source: Mass Device - June 15, 2016 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

Utilization of Emergent Neuroimaging for Thrombolysis‐Eligible Stroke Patients
CONCLUSIONSAmong acute stroke patients, noncontrast CT was the most common initial imaging strategy in clinical practice in the 2005–2012 time period, though use of concomitant CTA grew to one‐quarter of cases, suggestive of an upward trend.
Source: Journal of Neuroimaging - June 13, 2016 Category: Radiology Authors: Nerses Sanossian, Katherine A. Fu, David S. Liebeskind, Sidney Starkman, Scott Hamilton, J. Pablo Villablanca, Adrian M. Burgos, Robin Conwit, Jeffrey L. Saver Tags: Clinical Investigative Study Source Type: research

Utilization of Emergent Neuroimaging for Thrombolysis ‐Eligible Stroke Patients
CONCLUSIONSAmong acute stroke patients, noncontrast CT was the most common initial imaging strategy in clinical practice in the 2005–2012 time period, though use of concomitant CTA grew to one‐quarter of cases, suggestive of an upward trend.
Source: Journal of Neuroimaging - June 13, 2016 Category: Radiology Authors: Nerses Sanossian, Katherine A. Fu, David S. Liebeskind, Sidney Starkman, Scott Hamilton, J. Pablo Villablanca, Adrian M. Burgos, Robin Conwit, Jeffrey L. Saver Tags: Clinical Investigative Study Source Type: research

3 reasons your child shouldn’t go “gluten-free” (unless your doctor says so)
Follow me at @drClaire There is a puzzling and worrisome new phenomenon that I am seeing as a pediatrician: parents who are putting their children on gluten-free diets. It’s puzzling because in the vast majority of cases it isn’t necessary — and it’s worrisome because, although parents are doing it because they think it’s healthy, a gluten-free diet can be very unhealthy for children. Gluten is a protein found in wheat, rye, barley, and some other grains. It’s in bread and other baked goods, cereals, pastas — and in many other foods in small amounts. For people with celiac disease, even those small amounts ca...
Source: New Harvard Health Information - June 7, 2016 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Healthy Eating Parenting Source Type: news

Reversible Cerebral Vasoconstriction Syndrome Presenting With Visual Field Defects
Abstract: A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clinical course and neuroimaging findings were consistent with reversible cerebral vasoconstriction syndrome. Although r...
Source: Journal of Neuro-Ophthalmology - June 1, 2016 Category: Opthalmology Tags: Clinical Observation Source Type: research

Urinary potassium excretion and risk of cardiovascular events Cardiovascular disease risk
Conclusion: In this cohort with oversampling of subjects with albuminuria at baseline, urinary potassium excretion was not independently associated with a lower risk of cardiovascular events.
Source: American Journal of Clinical Nutrition - May 1, 2016 Category: Nutrition Authors: Kieneker, L. M., Gansevoort, R. T., de Boer, R. A., Brouwers, F. P., Feskens, E. J., Geleijnse, J. M., Navis, G., Bakker, S. J., Joosten, M. M., for The PREVEND Study Group Tags: Cardiovascular disease risk Source Type: research

What we learned about the role of antenatal magnesium sulfate for the prevention of cerebral palsy
Based on the convincing case control study of Nelson and Grether which suggested that the administration of magnesium sulfate to mothers prior to early preterm birth might protect their offspring from cerebral palsy, and a pilot study by John Hauth et al. at the University of Alabama at Birmingham, the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, with co-funding from the National Institute of Neurologic Disorders and Stroke embarked on the Beneficial Effects of Antenatal Magnesium (BEAM) Trial in 1997.
Source: Seminars in Perinatology - April 21, 2016 Category: Perinatology & Neonatology Authors: Dwight J. Rouse, Deborah Hirtz, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Source Type: research

Urinary potassium excretion and risk of cardiovascular events.
CONCLUSION: In this cohort with oversampling of subjects with albuminuria at baseline, urinary potassium excretion was not independently associated with a lower risk of cardiovascular events. PMID: 26984482 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - March 16, 2016 Category: Nutrition Authors: Kieneker LM, Gansevoort RT, de Boer RA, Brouwers FP, Feskens EJ, Geleijnse JM, Navis G, Bakker SJ, Joosten MM, PREVEND Study Group Tags: Am J Clin Nutr Source Type: research

Magnesium Sulfate in Water for Injection by Hospira: Recall - Incorrect Barcode Labeling on the Primary Container
Potential for delay in treatment that can result in life-threatening seizures, stroke, cerebral hemorrhage and maternal death, and attendant risks to the fetus, including fetal demise.
Source: FDA MedWatch - January 6, 2016 Category: American Health Source Type: news

Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial Brief Reports
Conclusions— In this large, multicenter prehospital trial, nearly 40% of every calls from the field to physician-investigators resulted in trial enrollments. The most common reasons for nonenrollment were out of window last known well time, prestroke confounding medical condition, and absence of a consent provider. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Kim, D.-H., Saver, J. L., Starkman, S., Liebeskind, D. S., Ali, L. K., Restrepo, L., Kim-Tenser, M., Valdes-Sueiras, M., Eckstein, M., Pratt, F., Stratton, S., Hamilton, S., Conwit, R., Sanossian, N., on behalf of the Field Administration of Stroke Therap Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Neuroprotectants Brief Reports Source Type: research

A woman with recurrent vomiting and body cramps
Clinical introduction A 68-year-old woman with pancreatic cancer undergoing chemotherapy presented to the emergency department with a week of vomiting and body cramps. Vital signs were: BP 130/70 mm Hg; HR 80 bpm; RR 14 bpm and oxygen saturation 100% while breathing ambient air. Laboratory investigations showed normal calcium, magnesium and albumin levels; hypokalaemia level at 2.3 mmol/L (normal range 3.5–5.0 mmol/L) and bicarbonate level at 42 mmol/L (normal range 22–29 mmol/L). While the nurse was taking vital signs, the patient complained of a right hand cramp (figure...
Source: Emergency Medicine Journal - November 23, 2015 Category: Emergency Medicine Authors: Yildiz, H., Dupriez, F. Tags: Pancreas and biliary tract, EMJ Image Challenge, Stroke, Ethics Source Type: research

Ten year experience of using a novel metabolic protocol in 'off pump' coronary artery bypass revascularization
Conclusions: Off-pump coronary artery bypass coupled with this novel metabolic protocol was associated with a low operative mortality and acceptable perioperative morbidities, including patients with left main coronary artery disease. These benefits are apparent at both short- and medium-term follow up.
Source: Therapeutic Advances in Cardiovascular Disease - November 16, 2015 Category: Cardiology Authors: Perkowski, D. J., Wagner, S., Muller, K., Schneider, J. R., St.Cyr, J. A. Tags: Original Research Source Type: research

Hemodynamic Stability During Pheochromocytoma Resection: Lessons Learned Over the Last Two Decades
Conclusions Postoperative outcomes following pheo resection have improved over the last two decades. Preoperative α-blockade plays a significant role in improving intraoperative hemodynamics and post-op outcomes. Increased doses of phenoxybenzamine and utilization of laparoscopic approaches have likely contributed to improved outcomes in the last decade. Intraoperative magnesium use may provide protection against hemodynamic instability and warrants further study.
Source: Annals of Surgical Oncology - November 14, 2015 Category: Cancer & Oncology Source Type: research