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Specialty: Neurology
Drug: Carbidopa/Levodopa

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Total 18 results found since Jan 2013.

Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
This study investigates if dopamine might affect plasticity by having a direct effect on synaptic plasticity through alterations in neurotransmitter release and re-uptake. Synaptogyrin is a synaptic vesicle protein that has been suggested to be involved in dopamine re-uptake in the synaptic terminal. Therefore, we investigated if levodopa has an effect on the expression of synaptogyrin 1. Thy1-YFP mice were subjected to photothrombosis as an experimental model of stroke. Starting two days after surgery they were treated with either levodopa or a vehicle solution (saline) on a daily basis until day seven following surgery. ...
Source: Brain Research Bulletin - December 1, 2019 Category: Neurology Authors: Häggman Henrikson J, Pombo Antunes AR, Wieloch T, Ruscher K Tags: Brain Res Bull Source Type: research

Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection?
Abstract Dystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen after stroke, injury, or as a result of genetic causes. LID is associated with Parkinson's disease (PD), emerging as a consequence of chronic therapy with levodopa, and may be either dystonic or choreiform. LID and dystonia share important phenomenological properties and mechanisms. Both LID and dystonia are generated by an integrated circuit involving the cortex, basal ganglia, thalamus and cerebellum. They also share dysregulation of striatal choliner...
Source: Neurobiology of Disease - August 20, 2019 Category: Neurology Authors: Calabresi P, Standaert DG Tags: Neurobiol Dis Source Type: research

Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Gary A Ford, Bipin B Bhakta, Alastair Cozens, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F Walker, Amanda J FarrinSummaryBackgroundDopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. We aimed to assess the safety and efficacy of co-careldopa plus routi...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research

A Kinematic Study of Progressive Micrographia in Parkinson's Disease
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of <10 years and 24 age-matched controls wrote the letter “e” repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson's Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last fi...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis revealed that PD is associated with an increase of CRP levels. CRP might be a risk factor for PD or PD leads to an inflammatory response. Introduction Parkinson's disease (PD) is one of the most complex neuro-degenerative disorders next to Alzheimer's disease. It is characterized by bradykinesia, tremor, rigidity, abnormal postural, and gait (1). PD has been recognized by the selective loss of dopaminergic neurons within the substantia nigra pars compacta, whereas the exact etiology remains elusive (2). Previously, multiple inferences have reviewed the environmental a...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Pharmacotherapy and motor recovery after stroke.
Authors: Viale L, Catoira NP, Di Girolamo G, González CD Abstract INTRODUCTION: Stroke is one of the most prevalent neurological diseases worldwide, especially among the elderly population. There are various mechanisms that enhance motor recovery after a stroke. In clinical practice, we have the opportunity to enhance plasticity by designing specific rehabilitation programs. Areas covered: There are a variety of drugs commonly administered to people after the acute phase of a stroke. These drugs may modify motor performance. Herein reviewed is the evidence concerning motor enhancement or decline in stroke patients, p...
Source: Expert Review of Neurotherapeutics - November 11, 2017 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Abstract Primary motor cortex (M1) plasticity is involved in motor learning and stroke motor recovery, and enhanced by increasing monoaminergic transmission. Age impacts these processes but there is a paucity of systematic studies on the effects of monoaminergic drugs in older adults. Here, in ten older adults (age 61+ 4 years, 4 males), we determine the effects of a single oral dose of carbidopa/levodopa (DOPA), d-amphetamine (AMPH), methylphenidate (MEPH) and placebo (PLAC) on M1 excitability and motor training-induced M1 plasticity. M1 plasticity is defined as training related long lasting changes in M1 excitab...
Source: Brain Research - June 17, 2017 Category: Neurology Authors: Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM Tags: Brain Res Source Type: research

Early reperfusion therapy in acute ischemic stroke after recent myocardial infarction
ABSTRACT Most known by his literary ability, the words of the neurologist Oliver Sacks (1933-2015) also had an impact on scientific community about the role of levodopa on parkinsonisms. Different from the most authors and based on his experience described on the book “ Awakenings ” , he had a pessimistic opinion about levodopa, which was related on many articles written by himself and colleagues in early 1970s. We reviewed the scientific contribution of Oliver Sacks associated to levodopa therapy on parkinsonisms, and how he advised caution with its complications before the majority of physicians.RESUMO Mais conhecido...
Source: Arquivos de Neuro-Psiquiatria - August 22, 2016 Category: Neurology Source Type: research

Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinsons Disease (APD) (P6.391)
Conclusions: Our findings suggest that patients, on average, prefer device aided treatments over oral therapy to improve movement symptoms in advanced PD, and that a portable infusion pump is preferred to DBS. Patient preferences are important and should be considered for therapeutic and access choices in advanced PD.Disclosure: Dr. Marshall has received personal compensation for activities with AbbVie, Inc. as an employee. Dr. Hauber has received research support from AbbVie. Dr. Fairchild has received research support from AbbVie. Dr. Sail has received personal compensation from AbbVie as an employee of the organization.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Marshall, T., Hauber, A. B., Fairchild, A., Sail, K. Tags: Movement Disorders: Parkinson ' s Disease II Source Type: research

L-dopa does not add to the success of high-intensity language training in aphasia.
CONCLUSION: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. PMID: 25588456 [PubMed - indexed for MEDLINE]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Parkinsonism, small vessel disease, and white matter disease: Is there a link?
Parkinsonian syndrome is primarily attributed to striato-nigral degeneration as idiopathic Parkinson disease (PD), although it can be caused by white matter (WM) disease as classically seen in vascular parkinsonism (VP). VP clinically manifests as predominant lower extremities involvement and gait impairment with poor response to levodopa and, radiologically, as WM hyperintensities (WMH) that disrupt the striato-nigral pathways. However, brain MRI vascular lesions correlate poorly with clinical manifestations and pathology findings.1
Source: Neurology - November 2, 2015 Category: Neurology Authors: Luca, C. C., Rundek, T. Tags: Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Dynamics of major histocompatibility complex class II-positive cells in the postischemic brain - influence of levodopa treatment
Conclusions: Results suggest that dopamine signaling is involved in the adaptive immune response after stroke and involves microglia/macrophages.
Source: Journal of Neuroinflammation - August 23, 2014 Category: Neurology Authors: Enida KuricKarsten Ruscher Source Type: research

Gender and Dopaminergic Medication Treatment in Early Parkinson Disease (P3.069)
CONCLUSIONS: Although we did not observe gender differences in the type and dose of dopaminergic treatment in LS-1 participants with early PD, further research is needed to evaluate gender influences on dopaminergic medication treatment in mid- and late-stage PD.Study Supported by: on behalf of the NET-PD LS1 investigators.Disclosure: Dr. Umeh has nothing to disclose. Dr. Pérez has nothing to disclose. Dr. Augustine has nothing to disclose. Dr. Dhall has received personal compensation for activities with UCP Pharma, Impax Pharmaceuticals, and Teva Neuroscience. Dr. Dewey has received personal compensation for activi...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Umeh, C., Perez, A., Augustine, E., Dhall, R., Dewey, R., Mari, Z., Simon, D., Wills, A. M., Christine, C., Schneider, J., Suchowersky, O. Tags: Movement Disorders: Clinical Features of Parkinson ' s Disease Source Type: research