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Drug: Aspirin
Therapy: Statin Therapy

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Total 230 results found since Jan 2013.

The Inhibitory Effect of Simvastatin and Aspirin on Histamine Responsiveness in Human Vascular Endothelial Cells.
Abstract Statins and aspirin deliver well-established cardiovascular benefits resulting in their increased use as combined polypills to decrease risk of stroke and heart disease. However, the direct endothelial effect of combined statin/aspirin cotreatment remains unclear. Histamine is an inflammatory mediator that increases vascular permeability and so we examined the effect of treating human umbilical vein endothelial cells (HUVECs) for 24-hours with 1μM simvastatin and 100μM aspirin on histamine responsiveness. Subsequent histamine (1μM) challenge increased Ca(2+)i concentration, an effect that was significa...
Source: Am J Physiol Cell Ph... - January 29, 2014 Category: Cytology Authors: Absi M, Bruce JI, Ward DT Tags: Am J Physiol Cell Physiol Source Type: research

Tissue kallikrein preventing the restenosis after stenting of symptomatic MCA atherosclerotic stenosis (KPRASS)
ConclusionAs our pilot study, tissue kallikrein would be expected to prevent the long‐term in‐stent restenosis after stenting of the symptomatic middle cerebral artery dramatically.
Source: International Journal of Stroke - December 21, 2013 Category: Neurology Authors: Wenya Lan, Fang Yang, Ling Liu, Qin Yin, Min Li, Zhuangli Li, Hongfei Sang, Gelin Xu, Minmin Ma, Zhizhong Zhang, Zhenguo Liu, Xinfeng Liu, Renliang Zhang Tags: Protocols Source Type: research

Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry
Abstract: Background: Patients with atrial fibrillation (AF) are at increased risk of thromboembolic events. The long-term prognostic implications of AF in patients with atherothrombosis are unknown.Methods: We compared 4-year CV outcomes in patients with and without a history of AF recorded at their baseline visit in the REACH Registry, an international, prospective cohort of patients with established atherosclerotic arterial disease (CAD, CVD, PAD) or at least 3 risk factors (RFO).Results: AF status and 4year follow-up data were available on 44,518 patients. The prevalence of AF at baseline was 10.3% (n=4582). Overall, p...
Source: International Journal of Cardiology - December 9, 2013 Category: Cardiology Authors: Christian T. Ruff, Deepak L. Bhatt, Ph. Gabriel Steg, Bernard J. Gersh, Mark J. Alberts, Elaine B. Hoffman, E. Magnus Ohman, Kim A. Eagle, Gregory Y.H. Lip, Shinya Goto, On Behalf of the REACH Registry Investigators Tags: Original Articles Source Type: research

An audit of management practices in patients with suspected temporary monocular blindness.
CONCLUSION: There is a need to improve professional awareness of the importance of starting best medical therapy and performing CEA as soon as possible after onset of TMB. PMID: 24187055 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - November 1, 2013 Category: Opthalmology Authors: Naylor AR, Robinson TG, Eveson D, Burns J Tags: Br J Ophthalmol Source Type: research

Efficacy of contemporary medical management for asymptomatic carotid artery stenosis.
Abstract In the Asymptomatic Carotid Artery Stenosis trial (1995), medical management was defined as aspirin in addition to adequate control of comorbidities. Since then, medical management of asymptomatic carotid artery stenosis (CAS) has progressed to include broader use of statins. Our purpose was to review the effect of contemporary medical management on stroke prevention. A retrospective review of the Kaiser Permanente, Southern California medical group database was performed. All patients with a diagnosis of asymptomatic CAS by International Classification of Diseases, 9th Revision codes from 2007 to 2011 we...
Source: The American Surgeon - October 1, 2013 Category: Surgery Authors: Chang J, Ahn JE, Landsman N, Rhee K, Chun L, Patel KK Tags: Am Surg Source Type: research

Long-Term Effects of Secondary Prevention on Cognitive Function in Stroke Patients.
CONCLUSIONS: Appropriate vascular risk management was associated with a long-term reduced risk of cognitive impairment. Focus on optimal preventive drug therapy of vascular risk factors and management should be supported. PMID: 23935013 [PubMed - as supplied by publisher]
Source: Circulation - August 9, 2013 Category: Cardiology Authors: Douiri A, McKevitt C, Emmett ES, Rudd AG, Wolfe CD Tags: Circulation Source Type: research

Urgent Best Medical Therapy May Obviate the Need for Urgent Surgery in Patients With Symptomatic Carotid Stenosis Clinical Sciences
Conclusions— CEA can be performed in the subacute period without significantly increasing the operative risk. The urgent best medical treatment was associated with significant reduction in the risk of early NR in CEA patients. It seems that urgent aggressive best medical treatment may obviate the need for urgent CEA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Shahidi, S., Owen-Falkenberg, A., Hjerpsted, U., Rai, A., Ellemann, K. Tags: Secondary prevention, Antiplatelets, Carotid endarterectomy, Transient Ischemic Attacks Clinical Sciences Source Type: research

The Effect of Tobacco Control Measures during a Period of Rising Cardiovascular Disease Risk in India: A Mathematical Model of Myocardial Infarction and Stroke
Conclusions Smoke-free laws and substantially increased tobacco taxation appear to be markedly potent population measures to avert future cardiovascular deaths in India. Despite the rise in co-morbid cardiovascular disease risk factors like hyperlipidemia and hypertension in low- and middle-income countries, tobacco control is likely to remain a highly effective strategy to reduce cardiovascular deaths.Please see later in the article for the Editors' Summary
Source: PLoS Medicine - July 9, 2013 Category: Internal Medicine Authors: Sanjay Basu et al. Source Type: research

RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA): study protocol for a pilot randomised controlled trial
DiscussionThis pilot study will be used to estimate key parameters that are needed to design the main study and to estimate the accuracy of primary care diagnosis of TIA. The planned follow-on trial will have important implications for the initial management of people with suspected TIA.Trial registration: ISRCTN62019087
Source: Trials - July 2, 2013 Category: Journals (General) Authors: Duncan EdwardsKate FletcherRachel DellerRichard McManusDaniel LassersonMatthew GilesDon SimsJohn NorrieGraham McGuireSimon CohnFiona WhittleVicky HobbsChristopher WeirJonathan Mant Source Type: research

Progression of asymptomatic carotid stenosis despite optimal medical therapy
Background: Despite level 1 evidence in support of carotid endarterectomy vs medical therapy in selected asymptomatic patients, an alternative posture is that optimal medical therapy (OMT) has not been adequately studied and that such OMT has reduced stroke risk in asymptomatic patients to levels wherein carotid endarterectomy is no longer justified. The goal of this study was to determine the natural history of patients with asymptomatic moderate (50%-69%) carotid artery stenosis (AMCAS) in a contemporary cohort as a function of their associated medical therapy.Methods: Patients with AMCAS determined by duplex ultrasound ...
Source: Journal of Vascular Surgery - June 30, 2013 Category: Surgery Authors: Mark F. Conrad, Valy Baloum, Shankha Mukhopadhyay, Ashu Garg, Virendra I. Patel, Richard P. Cambria Tags: Clinical research studies Source Type: research

Rapid Detection of Subclinical Atherosclerosis: Potential Implications for Primary Prevention in LMIC
An ounce of prevention is worth a pound of cure.—Benjamin Franklin This axiom, applied to health, is as true today as it was when it was originally quoted in reference to fire safety. Acute atherothrombotic cardiovascular events such as acute coronary syndromes, ischemic stroke, and sudden death are often (nearly 50% of the time) the first clinical manifestation of occult vascular disease in subjects unaware of existence of pre-symptomatic atherosclerosis. The overall burden of cardiovascular disease worldwide is significant, and nearly two-thirds of it originates from low- and middle-income countries (LMIC) . This ver...
Source: CVD Prevention and Control - June 1, 2013 Category: Cardiology Authors: Prediman K. Shah Tags: Editorial Comment Source Type: research

The Timing Hypothesis and Hormone Replacement Therapy: A Paradigm Shift in the Primary Prevention of Coronary Heart Disease in Women. Part 2: Comparative Risks
A major misperception concerning postmenopausal hormone replacement therapy (HRT) is that the associated risks are large in magnitude and unique to HRT, but over the past 10 years, sufficient data have accumulated so that the magnitude and perspective of risks associated with the primary coronary heart disease prevention therapies of statins, aspirin, and postmenopausal HRT have become more fully defined. Review of randomized controlled trials indicates that the risks of primary prevention therapies and other medications commonly used in women's health are of similar type and magnitude, with the majority of these risks ca...
Source: Journal of the American Geriatrics Society - May 20, 2013 Category: Geriatrics Authors: Howard N. Hodis, Wendy J. Mack Tags: Updates on Aging Source Type: research

Cerebral Infarction in a Case of Parry-Romberg Syndrome
Our objective is to report a rare coexistence of Parry-Romberg disease and ischemic stroke. Here, we report the case of a 34-year-old woman with Parry-Romberg syndrome who developed cerebral infarction. This patient developed sudden left-sided weakness and was admitted to our hospital. Magnetic resonance imaging revealed acute cerebral infarction in the posterior limb of the right internal capsule. The patient had been diagnosed with Parry-Romberg syndrome at the age of 12, and she had a history of migraine without aura. Transesophageal echocardiography revealed a patent foramen ovale, but no atrial septal aneurysm or deep...
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2013 Category: Neurology Authors: Yuji Tomizawa, Ryota Tanaka, Kiyoshi Sekiguchi, Yutaka Oji, Yasutaka Tanaka, Kazuo Yamashiro, Nobutaka Hattori Tags: Case Reports Source Type: research

Impact of Adding Aspirin to Beta-Blocker and Statin in High-Risk Patients Undergoing Major Vascular Surgery
In this study we evaluated the benefits of adding aspirin (A) to BB and S (ABBS), with/without angiotensin-converting enzyme inhibitor (ACE-I) on postoperative outcome in high-risk patients undergoing major vascular surgery.Methods: Analysis of consecutive patients undergoing elective vascular surgery at the University of Michigan Cardiovascular Center was performed. Univariate and multivariate analyses were done using cardiac risk index [Revised Cardiac Risk Index (RCRI), coronary artery disease (CAD), insulin-dependent diabetes mellitus (IDDM), cerebral vascular disease, renal dysfunction, congestive heart failure, and m...
Source: Annals of Vascular Surgery - March 25, 2013 Category: Surgery Authors: Wei C. Lau, James B. Froehlich, Elizabeth S. Jewell, Daniel G. Montgomery, Kristina M. Eng, Theresa A. Shields, Peter K. Henke, Kim A. Eagle Tags: Basic Data Underlying Clinical Decision-Making in Endovascular Therapy Source Type: research