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Total 87 results found since Jan 2013.

Minocycline-induced polyarteritis nodosa-like vasculitis presenting as brainstem stroke
This report shows that ischemic strokes may occur as a result of minocycline-induced vasculitis. While this is likely a rare association, recognition is important given the widespread use of minocycline and the potential for devastating consequences in a young population. Consequently, drug-induced vasculitis should be considered in patients with an ischemic stroke taking minocycline.
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research

Efficacy of Minocycline in Female Rats after Mild Diffuse Traumatic Brain Injury (I5-1B)
CONCLUSIONS: Treatment of female Sprague-Dawley rats in the acute to subacute time window with minocycline versus saline did not result in significant differences in microgliosis or astrogliosis at Day 16 post-injury as assessed by IHC. This contrasts with the reported efficacy of minocycline in male rodents after stroke and after focal models of TBI. Whether this lack of treatment effect of minocycline is attributable to differences between the responsiveness of male and female animals, or a difference in injury models, is the subject of further investigation. Study Supported by: Department of Defense and National Institu...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Turtzo, L., Janaria, N., Lescher, J., Tu, W., Frank, J. Tags: Pediatric Neurotrauma: From Coma to Concussions Data Blitz Presentations Source Type: research

Efficacy of Minocycline in Female Rats after Mild Diffuse Traumatic Brain Injury (P7.175)
CONCLUSIONS: Treatment of female Sprague-Dawley rats in the acute to subacute time window with minocycline versus saline did not result in significant differences in microgliosis or astrogliosis at Day 16 post-injury as assessed by IHC. This contrasts with the reported efficacy of minocycline in male rodents after stroke and after focal models of TBI. Whether this lack of treatment effect of minocycline is attributable to differences between the responsiveness of male and female animals, or a difference in injury models, is the subject of further investigation. Study Supported by: Department of Defense and National Institu...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Turtzo, L., Janaria, N., Lescher, J., Tu, W., Frank, J. Tags: Neuro Trauma, Critical Care, and Sports Neurology Source Type: research

Tim-3 cell signaling and iNOS are involved in the protective effects of ischemic postconditioning against focal ischemia in rats
We examined whether iNOS, nitrotyrosine, and COX-2, as well as galectin-9/Tim-3 are involved in the protective effects of IpostC in a rat focal ischemia model. Western blot and confocal immunofluoresent staining results indicate that IPostC significantly inhibited Tim-3 expression, and that galectin-9 expression was also inhibited. In addition, IPostC attenuated production of iNOS and nitrotyrosine, but not COX-2, suggesting that IPostC has distinct effects on these inflammatory factors. Furthermore, the inflammation inhibitor minocycline blocked Tim-3 and iNOS expression induced by stroke. Taken together, we show that the...
Source: Metabolic Brain Disease - March 6, 2015 Category: Neurology Source Type: research

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome
Conclusions Serum NfL concentrations in SCI patients show a close correlation with acute severity and neurological outcome. Our data provide evidence that serum NfL is of prognostic value in SCI patients for the first time. Further, blood NfL levels may qualify as drug response markers in SCI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 12, 2015 Category: Neurosurgery Authors: Kuhle, J., Gaiottino, J., Leppert, D., Petzold, A., Bestwick, J. P., Malaspina, A., Lu, C.-H., Dobson, R., Disanto, G., Norgren, N., Nissim, A., Kappos, L., Hurlbert, J., Yong, V. W., Giovannoni, G., Casha, S. Tags: Immunology (including allergy), Neurological injury, Spinal cord, Stroke, Trauma CNS / PNS, Trauma, Injury Spinal cord injury Source Type: research

Attenuation of acute stroke injury in rat brain by minocycline promotes blood¿brain barrier remodeling and alternative microglia/macrophage activation during recovery
Conclusions: Early minocycline treatment against reperfusion injury significantly promotes neurovascular remodeling during stroke recovery by reducing brain tissue loss, enhancing TJP expression in ischemic brains and facilitating neuroprotective phenotype alternative activation of microglia/macrophages.
Source: Journal of Neuroinflammation - February 10, 2015 Category: Neurology Authors: Yirong YangVictor SalayandiaJeffrey ThompsonLisa YangEduardo EstradaYi Yang Source Type: research

Preischemic Neuroprotective Effect of Minocycline and Sodium Ozagrel on Transient Cerebral Ischemic Rat Model.
This study showed that single doses of minocycline and ozagrel prior to stroke had neuroprotective effects. These agents will be useful not only in post-stroke therapy but also in stroke prevention in several cerebrovascular procedures like carotid endarterectomy, bypass procedure, endovascular angioplasty, thromboembolectomy or thrombolysis. PMID: 25555371 [PubMed - as supplied by publisher]
Source: Brain Research - December 30, 2014 Category: Neurology Authors: Park SI, Park SK, Jang KS, Han YM, Kim CH, Oh SJ Tags: Brain Res Source Type: research

Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.
Authors: Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T Abstract Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy ...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

The Relationship Between Serial 18  FPBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice
Conclusion [18 F]PBR06 PET imaging noninvasively characterizes the time course of SAN, and shows increased microglial activation is associated with decreased motor function.
Source: Molecular Imaging and Biology - November 17, 2014 Category: Molecular Biology Source Type: research

A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model
Conclusion In the future, combining these two safe and low cost interventions in the ambulance has the potential to “freeze” the penumbra and improve outcomes in stroke patients. This pre-clinical 2 × 2 design can be easily translated into a pre-hospital clinical trial.
Source: Experimental and Translational Stroke Medicine - October 9, 2014 Category: Neurology Source Type: research

A 2  × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model
ConclusionIn the future, combining these two safe and low cost interventions in the ambulance has the potential to “freeze” the penumbra and improve outcomes in stroke patients. This pre-clinical 2 × 2 design can be easily translated into a pre-hospital clinical trial.
Source: Experimental and Translational Stroke Medicine - October 9, 2014 Category: Neurology Source Type: research

Clinical Trials in Acute Ischemic Stroke
Abstract Acute ischemic stroke (AIS) is a major cause of mortality and disability and remains a serious and significant global health problem. The development of neurovascular protectants to treat AIS successfully has been beset by disappointments and setbacks. Many promising candidates have lacked significant pleiotropic protective activity for brain tissue and cerebral blood vessels in clinical trials, while those with protective activity have had poor bioavailability or high toxicity. Moreover, the majority of agents did not confer significant neurovascular protection or clinical efficacy, as measured by standa...
Source: CNS Drugs - August 27, 2014 Category: Neurology Source Type: research

An open‐label evaluator‐blinded clinical study of minocycline neuroprotection in ischemic stroke: gender‐dependent effect
ConclusionPatients with ischemic stroke who received oral minocycline daily for 5 days had significantly better neurological outcomes on day 90 than controls. However, females showed no significant clinical improvement compared to males.
Source: Acta Neurologica Scandinavica - August 23, 2014 Category: Neurology Authors: M. R. Amiri‐Nikpour, S. Nazarbaghi, M. Hamdi‐Holasou, Y. Rezaei Tags: Original Article Source Type: research

Preconditioned Stem Cells: a Promising Strategy for Cell-Based Ischemic Stroke Therapy.
Abstract Ischemic stroke is a leading cause of mortality and morbidity worldwide. Numerous therapeutic studies, including stem cell therapy, have been explored in order to find the possible approach treating cerebral ischemia effectively. However, massive grafted-cell death and low survival rate made us pessimistic about the widespread application of stem cell therapy. The approach of preconditioning stem cells became an attractive option due to its high cell viability after transplantation. In this review, we focused on preconditioning stem cells via cytokines, chemical drugs and other factors including interleuk...
Source: Current Drug Targets - June 23, 2014 Category: Drugs & Pharmacology Authors: Cai H, Zhang Z, Yang GY Tags: Curr Drug Targets Source Type: research