Efficacy of Minocycline in Female Rats after Mild Diffuse Traumatic Brain Injury (P7.175)

CONCLUSIONS: Treatment of female Sprague-Dawley rats in the acute to subacute time window with minocycline versus saline did not result in significant differences in microgliosis or astrogliosis at Day 16 post-injury as assessed by IHC. This contrasts with the reported efficacy of minocycline in male rodents after stroke and after focal models of TBI. Whether this lack of treatment effect of minocycline is attributable to differences between the responsiveness of male and female animals, or a difference in injury models, is the subject of further investigation. Study Supported by: Department of Defense and National Institutes of Health.Disclosure: Dr. Turtzo has nothing to disclose. Dr. Janaria has nothing to disclose. Dr. Lescher has nothing to disclose. Dr. Tu has nothing to disclose. Dr. Frank has nothing to disclose.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Turtzo, L., Janaria, N., Lescher, J., Tu, W., Frank, J. Tags: Neuro Trauma, Critical Care, and Sports Neurology Source Type: research