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Molecules, Vol. 28, Pages 3181: Scutellarin Alleviates Ischemic Brain Injury in the Acute Phase by Affecting the Activity of Neurotransmitters in Neurons
In this study, the protective effects of scutellarin on ischemic brain damage in the acute phase (within 12 h) were illustrated. In middle cerebral artery occlusion and reperfusion (MCAO/R) modeling rats, the Z-Longa score was significantly down-regulated by 25% and 23.1%, and the brain infarct size was reduced by 26.95 ± 0.03% and 25.63 ± 0.02% when responding to high-dose and low-dose scutellarin treatments, respectively. H&E and TUNEL staining results indicated that the neuron loss of the ischemic region was improved under scutellarin treatment. In order to investigate the mecha...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Chunguo Wang Yaoyu Liu Xi Liu Yuting Zhang Xingli Yan Xinqi Deng Jinli Shi Tags: Article Source Type: research

Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats
Exp Neurol. 2022 Jul 26:114181. doi: 10.1016/j.expneurol.2022.114181. Online ahead of print.ABSTRACTDrug discovery and development for stroke is challenging as evidenced by few drugs that have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-d-aspartate (NMDA) receptor antagonist that has been shown to be neuroprotective in various preclinical studies. We have identified an endogenous BBB uptake transport system for memantine: organic cation transporters 1 and 2 (Oct1/Oct2). Our goal was to evaluate Oct1/Oct2 as a required BBB mechanism for memantine neuroprotective effects. Male Sprague-Dawley rats (200...
Source: Experimental Neurology - July 29, 2022 Category: Neurology Authors: Joshua A Stanton Erica I Williams Robert D Betterton Thomas P Davis Patrick T Ronaldson Source Type: research

The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke
Publication date: August 2021Source: Journal of Clinical Neuroscience, Volume 90Author(s): Nahid Beladi Moghadam, Elham Pourheidar, Forouzan Ahmadpour, Hamidreza Kafi, Jamshid Salamzadeh, Saeed Nasiri, Mohammad Sistanizad
Source: Journal of Clinical Neuroscience - June 22, 2021 Category: Neuroscience Source Type: research

Beneficial effects of memantine on ischemia/reperfusion injury following torsion/detorsion induced testicular damage in rats: Improvement in histological and biochemical parameters
Testicular torsion is a common urologic emergency and one of the causes of infertility in males. Hence, prompt diagnosis and treatment are important to prevent testicular damages. It has been reported that memantine, a drug for Alzheimer's disease has anti-oxidative role against cerebral ischemic stroke and cardiac ischemia reperfusion.
Source: Journal of Pediatric Urology - April 28, 2021 Category: Urology & Nephrology Authors: Abbas Jafari, Hojat Ghasemnejad-Berenji, Mohadeseh Nemati, Sarvin Pashapour, Sonia Sadeghpour, Morteza Ghasemnejad-Berenji Source Type: research

Memantine, NMDA Receptor Antagonist, Attenuates ox-LDL-Induced Inflammation and Oxidative Stress via Activation of BDNF/TrkB Signaling Pathway in HUVECs
AbstractAtherosclerosis is a chronic cardiovascular disease and contributes to pathogenesis of most myocardial infarction and ischemic stroke. Additionally, N-methyl-d-aspartate (NMDA) receptor plays a crucial role in myocardial infarction and ischemic strokes. The aim of our study was to investigate the underlying mechanisms of memantine (MEM), the blocker of NMDA receptors, in the development of atherosclerosis. In our study, human umbilical vascular endothelial cells (HUVECs) were stimulated with low-density lipoprotein (ox-LDL) to establish an atherosclerotic cell model. Cell Counting Kit-8 (CCK-8) assay and TUNEL stai...
Source: Inflammation - March 22, 2021 Category: Allergy & Immunology Source Type: research

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice
Poststroke cognitive impairment is considered one of the main complications during the chronic phase of ischemic stroke. In the adult brain, the hippocampus regulates both encoding and retrieval of new information through adult neurogenesis. Nevertheless, the lack of predictive models and studies based on the forgetting processes hinders the understanding of memory alterations after stroke. Our aim was to explore whether poststroke neurogenesis participates in the development of long-term memory impairment. Here, we show a hippocampal neurogenesis burst that persisted 1 month after stroke and that correlated with an impair...
Source: Journal of Clinical Investigation - February 25, 2019 Category: Biomedical Science Authors: María Isabel Cuartero, Juan de la Parra, Alberto Pérez-Ruiz, Isabel Bravo-Ferrer, Violeta Durán-Laforet, Alicia García-Culebras, Juan Manuel García-Segura, Jagroop Dhaliwal, Paul W. Frankland, Ignacio Lizasoain, María Ángeles Moro Source Type: research

Stroke as a cause of death in death certificates of patients with dementia: a cohort study from the Swedish Dementia Registry.
CONCLUSIONS: There was relatively high number of patients that died from IS in their death certificate but had not been registered in Riksstroke in the year before death. This creates concerns on the accuracy of death certificate stroke diagnoses, particularly for deaths taking place outside of hospitals. PMID: 30280666 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - October 2, 2018 Category: Neurology Authors: Subic A, Zupanic E, von Euler M, Norrving B, Cermakova P, Religa D, Winblad B, Kramberger MG, Eriksdotter M, Garcia-Ptacek S Tags: Curr Alzheimer Res Source Type: research

Memantine Attenuates Cell Apoptosis by Suppressing the Calpain-Caspase-3 Pathway in an Experimental Model of Ischemic Stroke.
Abstract Ischemic stroke, the second leading cause of death worldwide, leads to excessive glutamate release, over-activation of N-methyl-D-aspartate receptor (NMDAR), and massive influx of calcium (Ca(2+)), which may activate calpain and caspase-3, resulting in cellular damage and death. Memantine is an uncompetitive NMDAR antagonist with low-affinity/fast off-rate. We investigated the potential mechanisms through which memantine protects against ischemic stroke in vitro and in vivo. Middle cerebral artery occlusion-reperfusion (MCAO) was performed to establish an experimental model of ischemic stroke. The neuropr...
Source: Experimental Cell Research - January 5, 2017 Category: Cytology Authors: Chen B, Wang G, Li W, Liu W, Lin R, Tao J, Jiang M, Chen L, Wang Y Tags: Exp Cell Res Source Type: research

Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia
Publication date: 1 April 2016 Source:Life Sciences, Volume 150 Author(s): Zheng-Zhen Chen, Dan-Dan Yang, Zhan Zhao, Hui Yan, Juan Ji, Xiu-Lan Sun Aims Memantine is a low-moderate affinity and uncompetitive N-methyl-d-aspartate receptor (NMDAR) antagonist, which is also a potential neuroprotectant in acute ischemic stroke for its particular action profiles. The present study was to reveal the mechanisms involved in the neuroprotection of memantine. Main methods We used a mouse model of permanent focal cerebral ischemia via middle cerebral artery occlusion to verify our hypothesis. 2,3,5-Triphenyltetrazolium chlori...
Source: Life Sciences - March 3, 2016 Category: Biology Source Type: research

A beacon of hope in stroke therapy—Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
Publication date: Available online 17 February 2016 Source:Pharmacology & Therapeutics Author(s): Ashfaqul Hoque, M. Iqbal Hossain, S. Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic C.H. Ng, Anderly Chueh, Carli Roulston, Heung-Chin Cheng Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal loss in acute and chronic neurological conditions such as ischaemic stroke, Alzheimer's and Huntington's diseases. Effective neuroprotective drugs to reduce excitotoxic neuronal loss in patients suffering from these neurological co...
Source: Pharmacology and Therapeutics - February 29, 2016 Category: Drugs & Pharmacology Source Type: research

A Beacon of Hope in Stroke Therapy - Blockade of Pathologically Activated Cellular Events in Excitotoxic Neuronal Death as Potential Neuroprotective Strategies
Publication date: Available online 17 February 2016 Source:Pharmacology & Therapeutics Author(s): Ashfaqul Hoque, M. Iqbal Hossain, Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic C.H. Ng, Anderly Chueh, Carli Roulston, Heung-Chin Cheng Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors is a major cause of neuronal loss in acute and chronic neurological conditions such as ischemic stroke, Alzheimer’s and Huntington’s diseases. Effective neuroprotective drugs to reduce excitotoxic neuronal loss in patients suffering from these neurological con...
Source: Pharmacology and Therapeutics - February 19, 2016 Category: Drugs & Pharmacology Source Type: research

The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects
obert Fern
Source: Journal of Cerebral Blood Flow and Metabolism - January 30, 2015 Category: Neuroscience Authors: Melissa TrotmanPhilipp VermehrenClaire L GibsonRobert Fern Tags: glutamate ischemia memantine NMDA receptor stroke Source Type: research

Combination of HBO and Memantine in Focal Cerebral Ischemia: Is There a Synergistic Effect?
In this study, we investigated whether or not MEM could prolong the narrow therapeutic window of HBO treatment. Transient focal cerebral ischemia was induced in male Sprague–Dawley rats by middle cerebral artery occlusion (MCAO) for 120 min. MCAO produced neurobehavioral deficits, increased infarction volume, increased Evans blue (EB) content and levels of pro-inflammatory factors, as well as depleted glutathione (GSH), and reduced catalase (CAT) and superoxide dismutase (SOD) activity in the ischemic ipsilateral hemisphere. The combination of 5 mg/kg MEM treatment 15 min after the onset of ischemic event and HBO ther...
Source: Molecular Neurobiology - October 30, 2014 Category: Neurology Source Type: research

Effects Of Memantine And Clopidogrel Alone And In Combination On Cerebral Ischemia In Rats (P1.098)
Conclusions: We found that memantine and clopidogrel treatment reduces oxidative stress in HIBH but the combined treatment is less effective in reducing oxidative stress. Because of the potential pharmacokinetic mechanisms, combined therapy is less effective in reducing oxidative stress.Disclosure: Dr. Özdemir has nothing to disclose. Dr. Ilhan has nothing to disclose. Dr. Demir has nothing to disclose. Dr. Akgün has nothing to disclose. Dr. Kapan has nothing to disclose. Dr. Eser has nothing to disclose. Dr. Berilgen has nothing to disclose. Dr. Balduz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ozdemir, H., Ilhan, S., Demir, C., Akgun, B., Kapan, O., Eser, A., Berilgen, M. S., Balduz, M. Tags: Cerebrovascular Disease and Interventional Neurology: Translational Science Source Type: research